No abstract available.
Liposarcoma*

No abstract available.
Liposarcoma

This is a case of a posterior mediastinal mass in an asymptomatic gentleman, which was resected successfully and he has been disease free for more than a year of follow up. The histopathology findings happen to be a rare occurrence.
Liposarcoma

Retroperitoneal liposarcoma is an uncommon tumor both in the pregnant and nonpregnant state. Its exact incidence is unknown because of its rarity. Due to its propensity for local recurrence, prognosis depends on histologic subtype and negative margins of resection. Surgery remains the mainstay of treatment, and timing is critical in terms of finding a surgically resectable lesion while balancing fetal risks. This report describes tumor recurrence in a pregnancy with a prior history of surgery for an atypical lipomatous tumor presenting as a retroperitoneal mass. After discussion with the multidisciplinary team, as well as with the patient’s consent, the plan was to defer surgery until 34 weeks, followed by scheduled tumor removal 2 weeks postpartum. She delivered abdominally to a baby girl with a good outcome. Histopathology showed dedifferentiated liposarcoma with a positive tumor margin. The patient has survived at 6-month follow-up and completed four cycles of chemotherapy with doxorubicin, ifosfamide, and mesna. However, surveillance imaging again showed tumor recurrence.
Liposarcoma

Myxoid liposarcoma is a subtype of liposarcoma. This specific subtype can be identified based on its characteristic histological and cytogenetical features. The tumor has a fusion transcript of the CHOP and TLS genes, which is caused by t(12;16)(q13;p11). Most of the fusion transcripts that have been identified fall into three categories, specifically type I (exons 7-2), type II (exons 5-2), and type III (exons 8-2). A total of seven myxoid liposarcomas associated with the rare phenomenon of cartilaginous differentiation have been documented in the literature. Currently, only one of these cases has been cytogenetically analyzed, and the analysis indicated that it was a type II TLS-CHOP fusion transcript in both the typical myxoid liposarcoma and cartilaginous areas. This study presents a second report of myxoid liposarcoma with cartilaginous differentiation, and includes a cytogenetical analysis of both the myxoid and cartilaginous areas.
Cartilage ; Liposarcoma ; Liposarcoma, Myxoid

No abstract available.
Liposarcoma, Myxoid*

No abstract available.
Extremities* ; Liposarcoma*

Giant lipomas in the proximal upper extremity are rare. Traditionally these are slow growing tumour and cause symptoms depending upon their size, position and compression of surrounding structures. Lipoma causing compression of median nerve in the forearm is rare. Surgical excision invariably leads to complete recovery. We present a case of a giant lipoma in forearm causing neuropathy of median nerve. It is difficult to clinically judge the extent of lipoma in atypical position and findings. MRI should be used in pre-operative evaluation of these cases. Surgical excision causes complete resolution of symptoms.
Lipoma ; Liposarcoma

Dedifferentiated liposarcoma is a soft tissue sarcoma of adipocytic lineage. Histopathology and immunohistochemistry are essential for diagnosis. A 51-year-old Filipino woman presented with a rapidly enlarging left gluteal tumor. Histopathology revealed a multilobulated tumor having prominent myxoid stroma with numerous stellate-shaped, atypical cells bearing atypical mitotic figures. Other lobules were composed of sheets of pleomorphic cells, with atypical mitotic figures. The tumor stained positively with alcian blue, vimentin, MDM2 and p16 stains. Other immunohistochemical (IHC) studies done (pancytokeratin, CK7, CK 20, CD 34, CEA, desmin, EMA, SMA, S100) showed negative results. After a 2 cm wide excision of the sarcoma, patient was free from local tumor recurrence for 2 months, after which she was lost to follow-up. We report this case and a brief review of the current literature on dedifferentiated liposarcoma.
Liposarcoma ; Immunohistochemistry

Liposarcoma of paratesticular origin is extremely rare and preoperative diagnosis is unusual. Myxoid type or liposarcoma is in general less malignant than testicular tumor and orchiectomy with high ligation and wide excision of tumor mass are probably the treatment of choice. We are present a case of myxoid liposarcoma and reviewed literatures.
Diagnosis ; Ligation ; Liposarcoma ; Liposarcoma, Myxoid* ; Orchiectomy