1.Situation of lipemia disorder in patients with reduced glucose toleration
Journal of Practical Medicine 2002;435(11):36-38
Study on 50 patients (male: 12, female: 38), between the ages of 72 and 40, with hypertension (62% of patients), obesity (60%) in which abdominal obesity (78%) was carried out in Bach Mai Hospital during July 2000- March 2001. The results found that the lipemia disorder frequently occurred in patients with reduced glucose toleration according to the classification of Fredrichson (type IV). 69% patients with the reduced glucose toleration had a lipemia disorder accompanying with hypertension. The risk of hypertension among these patients was higher 6.7 times than this among patients without the lipemia disorder. 93% patients with the reduced glucose toleration and obesity had a lipemia disorder. This rate in the patients with abnormal obesity was 97%; 100% of patients with the reduced glucose toleration had signs of coronary insufficiency
Glucose
;
Lipoprotein Lipase
;
Blood Glucose
2.Investigation of the changes of lipemia and proteinuria in process of treatment of nephrotic syndrome
Journal of Practical Medicine 2002;435(11):13-15
A study on the process of treatment of 40 patients with the nephritic syndrome, without the renal failure by prednisolone from 12/1996 to 5/1998 has shown that 100% patients had a high increased concentration of total cholesterol (CT) and low density lipoprotein (LDL); 90% patient had an increased concentration of triglyceride (TG) and 15% patient had an increased concentration of high density lipoprotein (HDL); 100% patients had an increased concentrations of proteinuria over 3.5 g/24 hours. After 2 weeks of treatment, the concentrations of CT, LDL, TG were reduced but were not significant different from these in baseline. The proteinuria was reduced to 40%; concentration of HDL was gradually increased. Their reductions were significant different from these before treatment but risks were high. 75% patients had negative proteinuria.
Nephrotic Syndrome
;
Proteinuria
;
Lipoprotein Lipase
;
therapy
;
Lipids
3.Homozygous LPL p.Gly188Glu Mutation in a Mexican Girl With Lipoprotein Lipase Deficiency.
Ana Gabriela COLIMA FAUSTO ; Juan Ramón GONZÁLEZ GARCÍA ; Teresita De Jesús HERNÁNDEZ FLORES ; Norma Alejandra VÁZQUEZ CÁRDENAS ; Nery Eduardo SOLÍS PERALES ; María Teresa MAGAÑA TORRES
Annals of Laboratory Medicine 2017;37(4):355-358
No abstract available.
Female*
;
Humans
;
Hyperlipoproteinemia Type I*
;
Lipoprotein Lipase*
;
Lipoproteins*
4.Homozygous LPL p.Gly188Glu Mutation in a Mexican Girl With Lipoprotein Lipase Deficiency.
Ana Gabriela COLIMA FAUSTO ; Juan Ramón GONZÁLEZ GARCÍA ; Teresita De Jesús HERNÁNDEZ FLORES ; Norma Alejandra VÁZQUEZ CÁRDENAS ; Nery Eduardo SOLÍS PERALES ; María Teresa MAGAÑA TORRES
Annals of Laboratory Medicine 2017;37(4):355-358
No abstract available.
Female*
;
Humans
;
Hyperlipoproteinemia Type I*
;
Lipoprotein Lipase*
;
Lipoproteins*
5.A study on the association between pregnancy-induced hypertension and Asn291Ser mutation for Lipoprotein lipase.
Young Joo KIM ; Gyung Soon LEE ; Jeffrey C MURRAY
Korean Journal of Obstetrics and Gynecology 2000;43(12):2231-2236
No abstract available.
Female
;
Hypertension, Pregnancy-Induced*
;
Lipoprotein Lipase*
;
Lipoproteins*
;
Pregnancy
6.Platycodi radix beverage ameliorates postprandial lipemia response through lipid clearance of triglyceride-rich lipoprotein: A randomized controlled study in healthy subjects with a high-fat load.
Hansol LEE ; Yeni LIM ; Soo Yeon PARK ; Soo Muk CHO ; Jeong Sook CHOE ; Sewon JEONG ; Jin Sook KWAK ; Oran KWON
Nutrition Research and Practice 2018;12(5):371-377
BACKGROUND/OBJECTIVES: Elevation of postprandial lipemia characterized by a rise in triglyceride (TG)-rich lipoproteins can increase the risk of atherogenesis. The objective of this study was to investigate postprandial lipemia response to a single dietary fat/sugar load test and monitor beneficial changes induced by the consumption of Platycodi radix (AP) beverage in healthy subjects. SUBJECTS/METHODS: A total of 52 subjects were randomly assigned to either placebo or AP beverage group with a high-fat shake in a randomized controlled crossover trial. Postprandial blood was collected at 0, 1, 2, 4, and 6 h and analyzed for TG and lipoprotein lipase mass. Inhibition of pancreatic lipase was determined in vitro. RESULTS: AP inhibited pancreatic lipase activity in vitro (IC₅₀ = 5 mg/mL). Compared to placebo beverage, AP beverage consumption with a high-fat shake induced significant increase of plasma lipoprotein lipase mass (P = 0.0111, β estimate = 4.2948) with significant reduction in very low-density lipoprotein (VLDL) TG concentration (P = 0.038, β estimate = −52.69) at 6 h. Based on significant correlation between high-fat dietary scores MEDFICTS and postprandial TG responses in VLDL (P = 0.0395, r = 0.2127), subgroup analysis revealed that 6 h-postprandial VLDL TG response was significantly decreased by AP consumption in subjects with MEDFICTS ≥ 40 (P = 0.0291, β estimate = −7214). CONCLUSIONS: AP beverage might have potential to alleviate postprandial lipemia through inhibiting pancreatic lipase activity and elevating lipoprotein lipase mass. Subgroup analysis revealed that subjects with high-fat dietary pattern could be classified as responders to AP beverage among all subjects.
Atherosclerosis
;
Beverages*
;
Healthy Volunteers*
;
Hyperlipidemias*
;
In Vitro Techniques
;
Lipase
;
Lipoprotein Lipase
;
Lipoproteins*
;
Plasma
;
Triglycerides
7.Inhibitory effects of Capsicum annuum L. water extracts on lipoprotein lipase activity in 3T3-L1 cells.
Jongmi BAEK ; Jaesung LEE ; Kyoungkon KIM ; Taewoo KIM ; Daejung KIM ; Cheonan KIM ; Kanazawa TSUTOMU ; Sarangowa OCHIR ; Kooyeon LEE ; Cheol Ho PARK ; Yong Jik LEE ; Myeon CHOE
Nutrition Research and Practice 2013;7(2):96-102
Obesity, an intractable metabolic disease, currently has no medical treatment without side effects, so studies have been actively carried out to find natural compounds that have anti-obesity activity with minimum side effects. In this study, the anti-obesity effects of water extracts of seven Capsicum annuum L. varieties being Putgochu (Pca), Oyee gochu (Oca), Kwari putgochu (Kca), Green pepper (Gca), Yellow paprika (Yca), Red paprika (Rca) and Cheongyang gochu (Cca), were examined through the evaluation of lipoprotein lipase (LPL) mRNA expression level in 3T3-L1 cells (mouse pre-adipocytes). After capsaicin elimination by chloroform defatting, freeze-dried powder of Cca was treated to 3T3-L1 cells and anti-obesity effects were examined by determining the LPL mRNA level using the RT-PCR method. Of the primary fractions, only proven fractions underwent secondary and tertiary refractionating to determine anti-obesity effects. From seven different Capsicum annuum L., there was a significant decrease of the LPL mRNA expression level of 50.9% in Cca treatment compared to the control group. A significant decrease of the LPL mRNA expression level was shown in primary fractions (Fr) 5 (36.2% decrease) and 6 (30.5% decrease) of the Cca water extracts. Due to the impurities checked by UPLC chromatography, Fr 5 and 6 were refractionated to determine the LPL mRNA expression level. Treatment of Fr 6-6 (35.8% decrease) and Fr 5-6 (35.3% decrease) showed a significant decrease in the LPL mRNA expression level. When analyzed using UPLC, major compounds of Fr 6-6 and Fr 5-6 were very similar. Subsequently, we refractionated Fr 6-6 and Fr 5-6 to isolate the major peak for structure elucidation. Treatment of Fr 5-6-1 (26.6% decrease) and Fr 6-6-1 (29.7% decrease) showed a significant decrease in the LPL mRNA expression level. Consequently, the fractions may have a possibility to ameliorate obesity through the decrease of the LPL mRNA expression level.
3T3-L1 Cells
;
Capsaicin
;
Capsicum
;
Chloroform
;
Chromatography
;
Lipoprotein Lipase
;
Lipoproteins
;
Metabolic Diseases
;
Obesity
;
RNA, Messenger
;
Water
8.Polymorphisms at the Lipoprotein Lipase Gene: Possible Associations with Coronary Artery Disease and Blood Lipid Levels in Koreans.
Hyun Jin CHUNG ; Yoe Min YOON ; Tae Hee HAN ; Hyosoon PARK ; Junghan SONG ; Jin Q KIM
Korean Journal of Clinical Pathology 1999;19(6):617-623
BACKGROUND: Lipoprotein lipase (LPL) gene polymorphisms have been found associated with coronary artery disease (CAD) and lipid levels, but their impact is less clearly established. The analysis of associations of LPL gene polymorphisms with CAD and lipid levels in Koreans was investigated. METHODS: Analysis of PvuII (intron 6), HindIII (intron 8), and Ser447-Ter (exon 9) polymorphisms of LPL gene were performed using restriction enzyme digestion of amplified DNA products and lipid levels were analyzed in healthy control subjects (n=228) and patients with CAD (n=166). RESULTS: PvuII, HindIII, and Ser447-Ter sites were in strong linkage disequilibrium. No statistical differences in the genotypic frequencies of PvuII, HindIII, and Ser447-Ter polymorphisms were observed between control and CAD groups. P2P2 genotype had higher triglyceride level in CAD group and lower HDL-cholesterol level in control group than the other genotypes (P1P1, P1P2). H2H2 genotype had higher triglyceride level in CAD group and lower HDL-cholesterol level in control group than the other genotypes (H1H1, H1H2). CONCLUSIONS: Genotypes of LPL PvuII, HindIII, and Ser447-Ter polymorphisms were not associated with CAD. Individuals with P2P2 and H2H2 genotypes, however, had higher triglyceride and lower HDL-cholesterol levels that is known to be the most commmon dyslipidaemia in CAD patients.
Coronary Artery Disease*
;
Coronary Vessels*
;
Digestion
;
DNA
;
Genotype
;
Humans
;
Linkage Disequilibrium
;
Lipoprotein Lipase*
;
Lipoproteins*
;
Triglycerides
9.A Case of Lipoprotein Lipase Deficiency inan Infant with Recurrent Pancreatitis.
Hae Jin PARK ; Byeong Sam CHOI ; Hye Ran YANG ; Ju Young CHANG ; Jae Sung KO ; Choong Ho SHIN ; Sei Won YANG ; Jeong Kee SEO
Korean Journal of Pediatric Gastroenterology and Nutrition 2009;12(1):79-83
Familial chylomicronemia syndrome is a rare disorder characterized by severe hypertriglyceridemia and fasting chylomicronemia. Causes of the syndrome include lipoprotein lipase (LPL) deficiency, apolipoprotein C-II deficiency, or the presence of inhibitors to LPL. We managed a 3-month-old girl who had recurrent acute pancreatitis caused by chylomicronemia. We report the first case of familial chylomicronemia in Korea caused by LPL deficiency in an infant with recurrent acute pancreatitis.
Fasting
;
Humans
;
Hyperlipoproteinemia Type I
;
Hypertriglyceridemia
;
Infant
;
Korea
;
Lipoprotein Lipase
;
Lipoproteins
;
Pancreatitis
10.Association between Low-Density Lipoprotein Subclasses and Lipoprotein Lipase Gene Polymorphisms in Coronary Artery Disease.
Jun Wan PARK ; Kyoung Un PARK ; Yeo Min YOON ; Young Soon JUNG ; Jung Han SONG ; Jin Q KIM
The Korean Journal of Laboratory Medicine 2002;22(5):312-318
BACKGROUND: A preponderance of small low-density lipoproteins (LDL subclass phenotype B) has been closely associated with a high-risk for coronary artery disease. Lipoprotein lipase (LPL) gene polymorphisms have been found to be associated with coronary artery disease and lipid levels; but their impact on LDL particle size is less clearly established. METHODS: The LDL subclass phenotype was analyzed in 114 normal controls and 131 patients with coronary artery disease using the LipoPrint LDL system (Quantimetrix Co., Redondo Beach, CA, USA). HindIII and PvuII polymorphisms of LPL genes were analyzed using PCR-RFLP. Ser447 -Ter polymorphisms of LPL gene were analyzed using the PCR-based method and using mismatched primer and restriction digestion. The analysis of their associations with the LDL subclass phenotype and the LDL score was investigated. RESULTS: No statistical differences in the allelic frequencies of HindIII, PvuII and Ser447 -Ter poly-morphisms were observed between the control and patient groups. The G allelic frequency of Ser447 -Ter polymorphism was significantly higher in phenotype B than in the phenotype AandI group (P=0.043). HindIII, PvuII and Ser447 -Ter sites were in strong linkage disequilibrium. CONCLUSIONS: HindIII, PvuII and Ser447 -Ter polymorphisms were not directly linked with coronary artery disease. However, the Ser447 -Ter polymorphism is associated with the small LDL particle, which results in a change in lipid metabolism and might have an effect on the development of coronary artery disease.
Coronary Artery Disease*
;
Coronary Vessels*
;
Digestion
;
Humans
;
Linkage Disequilibrium
;
Lipid Metabolism
;
Lipoprotein Lipase*
;
Lipoproteins*
;
Lipoproteins, LDL
;
Particle Size
;
Phenotype