ObjectiveTo investigate the correlation of TIMI risk score and plasma brain natriuretic peptide (BNP) in patients with Acute myocardial infarction. MethodsTIMI risk score were calculated in 63 patients with acute myocardial infarction;At the same time plasma brain natriuretic peptide were measured by enzyme-linked immune absorption assay(ELISA). Analyze the correlation of TIMI risk score and plasma brain natriuretic peptide. ResultsNine patients of 63 occurred cardiavascular events during hospitalization or follow-up( 14.3％ ). The incidence of MACE increased significantly with the rise of TIMI risk score and BNP level. The TIMI risk score was positively correlated with the plasma BNP level( r =0.73 ,P ＜ 0. 05 ). ConclusionThe higher TIMI risk score and BNP level, the worse the prognosis, it could be use to predict the prognosis.

Objective:To observe the effects of osteoprotegerin on osteoclasts in the occlusal tissue during tooth eruption in dog and analyze the mechanism. Methods: Six 7-day-old brood dogs were divided randomly to control and osteoprotegerin groups. The dogs in osteoprotegerin group were injected with osteoprotegerin for 3 days 1.5 mg/(kg?d). 5 days after injection the dogs were sacrificed and mandible were taken out for paraffin slice. The number of the osteoclasts in the occlusal tissue up the third mandibular premolar was detected by tartrate-resistance acid phosphatase(TRAP) staining. Immunohistochemistry was used to examine the expressions of RANKL. Results: The number of osteoclasts in osteoprotegerin group was less than that in the control group (P

Objective To observe the clinical efficacy of Bushen-Yiqi-Huayu capsule in the treatment of vascular dementia.Methods 58 cases who diagnosed with vascular dementia,Chinese Traditional Medicine fine for the gas deficiency and blood stasis,Tanzu patients were randomly divided into two groups:observation group with 30 patients(oral Bushen-Yiqi-Huayu capsule); control group with 28 cases (oral Piracetam tablet),Treatment course three-months. Results The total effective rate was 86.7 percent,compared with the control group (total effective rate 60.8%), and the difference was significant (P

AIM: To investigate the protective effects of quercetin on nephrotoxicity induced by cyclosporine A(CsA)in rats. METHODS: Male Sprague-Dawley (SD) rats were divided into four groups of seven rats each. Control group, quercetin (40 mg/kg) group, CsA (40mg/kg) group, CsA (40 mg/kg) plus quercetin (40 mg/kg) group. The all groups were administered once day respectively for 15 days. Twenty-four hour urines were collected at the 10th and 14th day respectively after administration to measure the content of urinary protein and urinary N-acetyl-?-D-glucosaminidase(NAG). The animals in all groups were sacrificed 4 h after the last administration. Blood samples were collected to measure serum creatinine(SCr), blood urea nitrogen(BUN). Kidneys were removed rapidly, excised and sectioned for histological analysis. Other kiney tissues were utilized for biochemical analysis. RESULTS: Quercetin prevented urinary protein, SCr, BUN, NAG, and kidneys histological alterations.Quercetin significantly decreased malondialdehyde(MDA) content while significantly increased glutathione(GSH) content and glutathione-S-transferase(GST), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), catalase(CAT) activities of kidneys tissues in the rats treated with CsA. CONCLUSION: Quercetin can effectively attenuate the nephrotoxicity induced by CsA.

Objective To search the status quo of students'thanatopsis in order to push focused education on terminal care to the nursing major students.Metheds To distribute home-made questionnaire to 268 nursing students.Results students who cannot talk about death normally account for 21.3 percent;who never considered death or unnecessary to consider death account for 12.9 percent of the total;who considered a lot account for 10 percent;who cannot handle terminally ill account for 74.3 percent;and who prefer self-suicide when suffered defeat account for 4.9 percent.Conclusion Nursing students have insufficient ideas of death,and they need to think deeply about the meaning of death and to nurture a positive outlook on death in order to get a correct terminal care education.

Objective To study the clinical application of low molecular weight heparin combined with psychological intervention in the prevention of deep venous thrombosis after lower limb fracture surgery.Methods 100 patients with lower limb fracture treated in our hospital from January 2013 to December 2016 were selected as the research object in the course of the study, and randomly divided into control group and experimental group, with 50 cases in each group,.The patients in control group were treated with routine lower limb physical pressure to prevent deep venous thrombosis after lower limb fracture.The patients in the experimental group were treated with low molecular heparin combined with psychological intervention to prevent deep vein thrombosis after lower limb fracture.Comparative analysis of patients with prothrombin time and platelet and the experimental group and the control of activated partial thromboplastin time index.Results After different treatment, the platelet index of the experimental group was(189.23±36.23)×109 /L, significantly better than that of the control group(264.34±39.56)×109/L,the difference was statistically significant(P<0.05).After treatment, the patients in the experimental group the activated partial thromboplastin time and prothrombin time index respectively(35.62±4.23)s and(16.12±2.19)s, significantly better than the control group, the difference was statistically significant(P<0.05).Conclusion low molecular weight heparin combined with application of psychological intervention in prevention of deep venous thrombosis after lower limb fracture surgery, can improve clinical curative effect on prevention of deep vein thrombosis in a large extent, improve blood hypercoagulable state of patients after surgery, with further clinical promotion and application significance.

In recent years, the incidence of the allergic skin diseases is increasing as the growing of the pressure, the changes of the environment and other factors. The clinical features of the allergic skin diseases are easily repeated and in long course. It is found that the incidence of clinical allergic skin diseases, in addition to the season, diet and emotional relevant, is also closely linked to the physical deterioration of patients. Therefore, in addition to the emphasis on the treatment of the current symptoms of patients, adjustment and treatment of phsical constitution of patients and improvement of the adaptability of patients to environmental changes should attract attention, thereby reducing the frequency of incidence and alleviating the symptoms. The application of the abdominal acupuncture combined with body acupuncture for the improvement of the symptoms and physical constitution of allergic skin disease patients has obvious efficacy, which should be applied and promoted in clinic.

Objective To investigate the efficacy and safety of HCPT combined with 5-fluorouracil(5-Fu) in treatment of bladder cancer .Methods Selected 92 patients with advanced bladder cancer in our hospi-tal from February 2011 to August 2015 , equally divided into observation group and control group of 46 patients based on the random number table ,the control group were received 5-Fu intravesical chemotherapy ,The obser-vation group were given the HCPT combined with 5-Fu chemotherapy ,the chemotherapy infusion were once a week,continuous perfusion were observed for 3 months.Results The response rates in the observation group was 95.7%and the control group was 76.1%,the observation group were significantly higher than the control group (P<0.05).The occurrence of bladder irritation adverse reaction ,blood abnormalities,liver and kidney dysfunc-tion,bone marrow suppression in the observation group during chemotherapy compared with the control group were no significant difference(P>0.05),all adverse reactions after symptomatic treatment were improved .All patients were followed up for 1 year,The mortality and recurrence rates in the observation group were 8.7%and 4.3%re-spectively,while the control group were 30.4%and 17.4%,the mortality and recurrence rates of the observation group were significantly lower than the control group (P<0.05).Conclusion HCPT combined with 5 -Fu chemotherapy for bladder cancer has strong anti -cancer effect and without increase the incidence of adverse re-actions,it can promote the improvement of the long -term prognosis,so it is a safe and effective topical bladder chemotherapy drugs .

Since the complain center of our hospital was founded in 2011, innovated the philosophy of “com-plain is gold”.It transformed mentality of the leaderships and employees to treat complaints fundamentally .Complain management was regarded as a strategic tool for the hospital to self -improve;Complain was regarded “the third eye”of recognizing the hospital management blind spots or service failure .At the same time, our hospital takes it as an im-portant means to construct the harmonious doctor -patient relationship sincerely .In the past three years , under the guidance of new ideas , our hospital has been innovating the complaint handling mechanism and improving work processes .And we have obtained better result in complaints management under the effort of all the staff .

OBJECTIVE To explore the prevention mesures of hospital infection in aged patients with long-term central vein catheterization.METHODS The clinical data of 26 aged patients with long-term central vein catheterization from Mar 2005 to Oct 2006 were analyzed retrospectively.RESULTS Among 26 aged patients with long-term central vein catheterization,no related hospital infection occurred with average 7 d hospitalization.Swelling in upper extremities was observed in 5 patients.CONCLUSIONS The mesures,such as aseptic procedure for changing transfusion device periodically and using effective filter can effectively prevent the infection.