Objective To discuss the clinical value of united detection of myocardial enzymes and troponin in the diagnosis of hypothyroidism.Methods 27 patients with hypothyroidism were chosen as the observation group.26 healthy volunteers were selected as the control group.CK-MB,LDH,AST,FT3,FT4,TSH,cTnT,cTnI were detected.Results The levels of serum AST,LDH,CK-MB of the observation group were significantly increased,the mean value was(52.67 ± 7.32)U/L,(265.23 ± 101.34)U/L,(26.75 ± 18.75)U/L respectively,which were significantly higher than the control group,the differences were statistically significant(P ＜ 0.05).The c TnT and c TnI positive rate of patients in observation group were 70.4％ and 81.5％,compared with the control group,the rates were much higher (P ＜ 0.05).Conclusion The united detection of myocardial enzymes and troponin had high clinical value in the diagnosis of hypothyroidism.

Objective To explore the impacts of leukoaraiosls (LA) on the short-term outcome of acute cerebral infarction. Methods 204 patients after acute cerebral infarction were reviewed from January 2012 to August 2014. They were divided into 4 groups according to the brain magnetic resonance imaging: cerebral infarction without LA (LA-0), and with LA (LA-1, LA-2 and LA-3). The Logistic regression analysis was applied with the short-term outcome of cerebral infarction as the dependent variable, and 16 possible factor as independent variables. Results There were 4 independent factors risk to the worse outcome of acute cerebral infarction, including LA, age, hypertension and cerebral infarction size (OR>1, P<0.05). Conclusion LA is an independent risk factors to the worse short-term outcome of acute cerebral infarction.

Objective To investigate the impact of stenting at the origin of vertebral artery(VAO)on cognitive function in patients with first-onset temporal or thalamic infarction.Methods A total of 65 patients with first-onset temporal or thalamic infarction were selected as research subjects,and were diagnosed with new-onset infarction in the medial temporal lobe or thalamus by craniocere-bral magnetic resonance imaging(MRI),and severe stenosis of VAO as the responsible vessel for in-farction was confirmed by head and neck computed tomography angiography(CTA).A total of 35 pa-tients who received VAO stenting were included in the stenting group,and 30 patients who received drug-based conservative treatment were included in the control group.The Montreal Cognitive Assess-ment Scale(MoCA),Wechsler Adult Intelligence Scale-Digit Span Test(WAIS-DS),and Fuld Ob-ject Memory Evaluation Scale(FOM)scores were compared between the two groups before treatment,14 days and 3 months after treatment.Results Before treatment,there was no significant difference in the scores of each scale between the two groups(P＞0.05).At 14 days and 3 months after treat-ment,the total MoCA score and the scores of visual space and executive function,delayed recall,and language dimension in the stenting group were higher than those in the control group(P＜0.05).The FOM score in the stenting group was higher than that in the control group at 3 months after treat-ment(P＜0.05).Conclusion Stenting can significantly improve the cognitive function of patients with temporal lobe and thalamic infarction.

Objective To investigate the impact of stenting at the origin of vertebral artery(VAO)on cognitive function in patients with first-onset temporal or thalamic infarction.Methods A total of 65 patients with first-onset temporal or thalamic infarction were selected as research subjects,and were diagnosed with new-onset infarction in the medial temporal lobe or thalamus by craniocere-bral magnetic resonance imaging(MRI),and severe stenosis of VAO as the responsible vessel for in-farction was confirmed by head and neck computed tomography angiography(CTA).A total of 35 pa-tients who received VAO stenting were included in the stenting group,and 30 patients who received drug-based conservative treatment were included in the control group.The Montreal Cognitive Assess-ment Scale(MoCA),Wechsler Adult Intelligence Scale-Digit Span Test(WAIS-DS),and Fuld Ob-ject Memory Evaluation Scale(FOM)scores were compared between the two groups before treatment,14 days and 3 months after treatment.Results Before treatment,there was no significant difference in the scores of each scale between the two groups(P＞0.05).At 14 days and 3 months after treat-ment,the total MoCA score and the scores of visual space and executive function,delayed recall,and language dimension in the stenting group were higher than those in the control group(P＜0.05).The FOM score in the stenting group was higher than that in the control group at 3 months after treat-ment(P＜0.05).Conclusion Stenting can significantly improve the cognitive function of patients with temporal lobe and thalamic infarction.

This study was carried out by the methods of typical plots investigation and laboratory test aiming at analyzing the survival state and fruiting characteristics of three Sinopodophyllum hexandrum populations in different environmental habitats. Meanwhile, it could provide scientific basis for enhancing wild population quantity recovery. The results showed that more population quantity grow in the habitats of large-area gap (Population A) and bushes (Population C) with a majority of the young individuals, while the minor-area gap (Population B) was the opposite. The development tendency of S. hexandrum populations would be the recession in the future. Spatial distribution pattern of populations was clumped at small scales but random at large scales. The indexes of population A and C, as fruit size，the quantity and quality of seeds，germ inability，were all superior to those of population B. Comparing the mainly environment factors of three populations, that favorable environmental factors for vegetative and reproductive growth of S. hexandrum populations were found，especially certain lighting intensity and fertile soil. Therefore, the favorable environmental habitats for S. hexandrum individuals growth could be artificial to promote the recovery and quantities of S. hexandrum populations in the future.

Objective:To explore the relationship between olfactory dysfunction and mild cognitive impairment (MCI) among elderly people in the community so as to provide a reference for screening and risk factor management of the MCI population.Methods:From March to June 2023, elderly individuals from Donghuashi and Fangzhuang communities in Beijing were selected as the study subjects by convenience sampling. Study subjects were surveyed using the General Information Questionnaire, Mini-Mental State Examination, Montreal Cognitive Assessment, Barthel Index, Sniffin' Sticks Test, 7-item Generalized Anxiety Disorder Scale, and 15-item Geriatric Depression Scale. Binary logistic regression was used to analyze the factors that influence MCI among elderly people in the community.Results:A total of 252 questionnaires were distributed and 243 valid questionnaires were collected, with an effective response rate of 96.4% (243/252). Among 243 elderly people in the community, 75 experienced MCI, with an incidence of 30.9% (75/243). Binary Logistic regression analysis showed that the probability of MCI in elderly people with olfactory dysfunctions was 1.979 times that in elderly people without olfactory dysfunctions and age, previous occupational type and frequency of mental activity were the influencing factors for the occurrence of MCI ( P<0.05) . Conclusions:The incidence of MCI is high among elderly people in the community, especially those with olfactory dysfunctions. Nursing staff should pay attention to the role of olfactory dysfunction in cognitive function screening and risk factor management.

Objective This study aims at establishing a teaching catalog and content for breast rare dis-eases and developing the syllabus for the breast rare disease using integrated multimodality of case-/problem-/resource-based learning(CBL+PBL+RBL).Methods By conducting bibliometrics co-occurrence analysis,we collected 6291 articles on breast rare disease published from January,1975 to June,2024.Additionally,we re-trieved the Textbook on Rare Diseases,the Catalog of Chinese Rare Disease,and Second Batch of Rare Dis-ease Catalog and then decided the teaching content.Results From 16,387 keywords,1000(6.1％)keywords were identified through co-occurrence analysis,including 50(0.3％)candidate diseases.These were classified into three categories:rare primary breast diseases,rare genetic mutation-related diseases associated with breast cancer,and rare systemic multi-system diseases involving the breast.From the candidate list,20(0.1％)rare primary breast diseases were further selected for their notable clinical teaching significance,and significant multi-systemic diseases affecting the breast,whether related to gene mutations or not.Teaching plans were draf-ted using a diversified parallel teaching approaches,taking into account the characteristics of different diseases and the focus of different teaching methods.Conclusions This study initiated the development of the teaching content for breast rare diseases and developed the teaching syllabus using the CBL+PBL+RBL integrated multi teaching model and targeting each rare breast disease for the critical point for teaching.