Objective To investigate the features of multi-slice helical CT and upper gastrointestinal manifestations for primary gastric lymphoma in order to improve diagnostic accuracy.Methods Data from 24 patients with pathologically confirmed primary gastric lymphoma and applied multi-slice helical CT and upper gastrointestinal findings were retrospectively analyzed.Their characteristics were summarized.Results All 24 patients were B cell originating of non-Hodgkin' s lymphoma.The characteristics of multi-slice helical CT manifestations were as follows:multiple lesions,equal density,homogeneous enhancement,thickening widely of the stomach wall but soft,perigastric lymph nodes enlargement.Upper gastrointestinal performance:lesions varied,complex,multiple or single nodules,multiple superficial ulcers,gastric wall thicken diffusely but having squirm and stomach cavity without narrowing.Conclusion There are some specific characteristics in multi-slice helical CT and upper gastrointestinal of primary gastric lymphoma and in might be importance for diagnosis and differential diagnosis.