Objective:To investigate the correlation between histologic chorioamnionitis(HCA) and periventricular leukomalacia(PVL) in preterm infants less than 34 weeks old.Methods:A total of 287 preterm infants born in Qingdao Women′s and Children′s Hospital from January 2018 to December 2018, whose mothers underwent placental pathological examination and preterm infants transferred to the neonatal intensive care unit for treatment, and whose gestational age was less than 34 weeks old, were selected as the study objects. According to the results of placental pathological examination, the infants were divided into two groups: the positive HCA group(167 cases)and the negative HCA group(120 cases). The incidence of PVL was compared between the two groups. According to the results of placental pathological examination and the stage standard of HCA, the preterm infants who had been diagnosed with PVL(41 cases) were divided into three groups: the non-HCA group, the early HCA group and the middle/late HCA group.The severity of PVL, clinical data, complications were compared in each groups, and the conditions that following up to 6 months were adjusted.Results:PVL was 19.16%(32/167) in the positive HCA group and was 7.50%(9/120) in the negative HCA group.There was significant difference in the incidence of PVL between the two groups( P<0.05). Among the preterm infants with PVL, 21.95%(9/41) was in non-HCA group, 31.71%(13/41) was in the early HCA group, and 46.34%(19/41) was in the middle/late HCA group.The severity of PVL, 1 min Apgar score, white blood cell count at 24 h after birth, the incidence of bronchopulmonary dysplasia, the number of hospital stay, the use of antibiotics, the mental development index(MDI) and psychomotor development index(PDI) at the adjusted gestational age to 6 months were significant differences among the three groups( P<0.05). Moreover, the degree of HCA inflammation was positively correlated with the severity of PVL( r s=0.374, P=0.016). Conclusion:There is a correlation between HCA and PVL in premature less than 34 weeks old.With the increasing of HCA inflammation, the incidence and severity of PVL increase. With the progression of the severity of inflammation, the white blood cell count at 24 h after birth, the incidence of bronchopulmonary dysplasia, the use of antibiotics and the time of hospital stay increase, the MDI and PDI scores at the adjusted gestational age to 6 months decrease.

OBJECTIVETo explore the impact of isolated diastolic hypertension (IDH) on new-onset cardio-cerebral vascular diseases (CVD).

METHODSThis cohort study involved 101 510 participants who were employees of the Kailuan Group-a state-run coal mining company, in 2006 and 2007. Among them, 6 780 subjects were diagnosed with IDH, 35 448 subjects were diagnosed with high-normal blood pressure and 19 460 subjects were diagnosed with normal tension. However, none of them had the history of either cardio-cerebral vascular disease or malignant cancer. Cardio-cerebral vascular events including cerebral infarction, cerebral hemorrhage, acute myocardial infarction were recorded every 6 months during the follow-up (47.1 ± 4.8) period. Multivariable Cox proportional hazards regression models were used to analyze the risk factors of first-ever CVD events.

RESULTS1) There were 675 CVD events occurred during the follow-up period. The incidence rates of CVD events (1.7% vs. 0.9%), cerebral infarction (1.0% vs. 0.6%) and cerebral hemorrhage (0.4% vs. 0.1%) were significantly higher in IDH group than that in the normal tension group (all P < 0.05). 2) After adjustment for other established CVD risk factors, the hazards ratios became 1.67 (95% CI: 1.28-2.17) for total CVD events and 1.59 (95% CI: 1.12-2.27) for cerebral infarction and 2.67 (95% CI: 1.54-4.65) for cerebral hemorrhage in the IDH group. 3). In stratified analysis on age, after adjustment for other established CVD risk factors, the hazards ratio was 2.22 (95% CI: 1.41-3.50) for cerebral infarction in lower 60 years old group, while the it was 7.27 (95% CI: 2.58-20.42) for cerebral hemorrhage in groups older than 60 years of age.

CONCLUSIONIDH was the independent risk factor for the total cardio-cerebral vascular events, on both cerebral infarction and cerebral hemorrhage. The predicted values of IDH for different CVD events were diverse on different age groups.

Adult ; Cardiovascular Diseases ; epidemiology ; Female ; Follow-Up Studies ; Humans ; Hypertension ; complications ; Male ; Middle Aged ; Proportional Hazards Models ; Risk Factors

OBJECTIVETo explore the prevalence of isolated diastolic hypertension and associated cardiovascular risk and blood pressure changes during follow up.

METHODSThis cohort study screened 101 510 participants who were employees of the Kailuan Group, a state-run coal mining company in 2006 and 2007. Among them, 6 778 subjects were diagnosed with isolated diastolic hypertension (IDH). IDH subjects without history of cardiovascular disease and not treated with antihypertensive drugs were included in this analysis. Participants without health examination between 2008 to 2009 or 2010 to 2011 were excluded. A total of 4 600 participants were included in the final analysis. At the end of the third health examination, the conversion rate of different blood pressure turnover was calculated after standardizing age and gender according to demographic data of China in 2006. Multivariate logistic regression analysis was applied to analyze the risk factors of blood pressure turnover in IDH population.

RESULTS(1) Participants were followed up for (4.03 ± 0.26) years and the rates of turnover from IDH to normotension, isolated systolic hypertension (ISH) and systolic diastolic hypertension (SDH) were 51.4%, 3.5%, 18.3%, respectively (45.6%, 3.6%, 22.0% in male, 57.4%, 3.3%, 14.7% in female). (2) Multivariate logistic regression analysis showed that low baseline age, low diastolic pressure, low body mass index, low uric acid, physical exercise and low alcohol intake were associated with turnover from IDH to normotension; the risk factors of turnover from IDH to ISH were older age at baseline, higher systolic pressure and higher sensitivity C-reactive protein; the risk factors of turnover from IDH to SDH were older baseline age, high systolic pressure and excessive salt intake.

CONCLUSIONSUntreated subjects with IDH can transform from IDH to normotension,ISH, SDH, and the rate of turnover from IDH to normotension is higher than others during follow up. Aging, higher systolic pressure, higher sensitivity C-reactive protein and excessive salt intake are risk factors for IDH subjects to suffer from ISH and SDH.

Adult ; Cohort Studies ; Female ; Follow-Up Studies ; Humans ; Hypertension ; epidemiology ; Logistic Models ; Male ; Middle Aged ; Prevalence ; Prognosis ; Risk Factors

OBJECTIVETo compare the prevalence of hypertension between low birth weight infant (LBWI) women and non-LBWI women.

METHODSA retrospective cohort study was applied and 3 172 pregnant women giving births during October 1976 to December 2008 in our hospital and underwent physical check-up between 2010 and 2011 at the Kailuan medical group were included and divided into LBWI group and non-LBWI group by the history of LBWI. Prevalence of hypertension was obtained during the follow-up program. Multiple logistic regression analysis was used to assess the relative risk of hypertension.

RESULTSA total number of 3 172 women, with an average age of 42.3 years old were divided into LBWI group (n = 147) and non-LBWI group (n = 3 025), with the average birth weights of their infants were 2.31 kg and 3.39 kg, respectively. The prevalence of hypertension from the follow-up program was significantly higher in LBWI group than that in the non-LBWI group (23.8% vs. 16.9%, P < 0.05). After adjustment for other traditional risk factors, the risk of hypertension in LBWI group was 1.60 (95%CI:1.02-2.53) folds higher than that in the non-LBWI group.

CONCLUSIONPrevalence of hypertension in women with LBWI was higher than that in those women without LBWI. History of LBWI seemed to have had an increased risk to develop hypertension.

Adult ; Female ; Humans ; Hypertension ; epidemiology ; Infant, Low Birth Weight ; Logistic Models ; Postpartum Period ; Pregnancy ; Prevalence ; Retrospective Studies ; Risk Factors ; Young Adult

OBJECTIVETo investigate the impact of different levels of systolic blood pressure on brachial-ankle pulse wave velocity (baPWV).

METHODSA total of 5 852 participants was selected with stratified random sampling from the 101 510 workers of Tangshan Kailuan Company who had undergone a physical check-up program. 5 222 of them with integral data were recruited into this survey. According to SBP collected during the 2010-2011 health examination program, the population under observation was divided into four groups:optimal SBP(SBP < 120 mmHg), high-normal blood pressure I period (120 mmHg ≤ SBP < 130 mmHg), high-normal blood pressure II period (130 mmHg ≤ SBP < 140 mmHg)and hypertension (SBP ≥ 140 mmHg or SBP < 140 mmHg but antihypertensive drug user). Multivariate logistic regression analysis was used to analyze the influence of different levels of systolic blood pressure on baPWV.

RESULTS1) There were 3 132 males and 2 090 females in all the 5 222 participants with an average age of 55.1 years old. Their mean of baPWV was (1 587.57 ± 400.71) cm/s, with the detection rates as 62% (baPWV ≥ 1 400 cm/s). 2)The means of baPWV for the above groups of SBP were 1 322.19, 1 456.27, 1 544.78 and 1 827.77 cm/s, respectively, with detection rates of baPWV ≥ 1 400 cm/s as 26.4% , 49.3% , 64.2% and 88.3% , respectively. 3) Results from the Multiple linear regression analysis revealed that β of SBP was 0.40, only ranking second, on age (0.48). 4) Data from the Multiple logistic regression analysis showed that after adjusting for age, gender and other risk factors, when compared to optimal SBP, factors as high-normal blood pressure I period, high-normal blood pressure II period and hypertension were risk factors for increasing baPWV, with OR values as 2.70 (95% CI:2.20-3.32), 4.56(95% CI: 3.67-5.67) and 13.51 (95% CI:10.87-16.78), respectively.

CONCLUSIONHigher SBP seemed an independent risk factor for the increase of baPWV.

Adult ; Aged ; Ankle Brachial Index ; Blood Pressure ; physiology ; Cross-Sectional Studies ; Female ; Humans ; Male ; Middle Aged ; Pulse Wave Analysis ; Risk Factors ; Surveys and Questionnaires ; Systole

OBJECTIVESThe function of the semicircular canal receptors and the pathway of the vestibulo-ocular reflex (VOR) can be diagnosed with the clinical head impulse test. The aim of the study was to investigate the horizontal VOR by means of video head impulse test in peripheral vestibular disorders.

METHODSUsing the vHIT, we examined horizontal semicircular canal VOR in a group of 55 patients and a control group of 20 healthy subjects. The group of patients included 10 cases of vestibular neuritis (VN), 6 cases of vestibular schwannoma (VS), 12 cases of Meniere's disease (MD), and 15 cases of bilateral vestibulopathy (BV), as well as 13 cases of idiopathic sudden hearing loss with vertigo (ISHL).

RESULTSInstantaneous gains of 40 ms, 60 ms and 80 ms of horizontal VOR were 0.88 ± 0.17, 0.94 ± 0.13 and 0.96 ± 0.13, respectively. Regression gain at 60 ms was 0.99 ± 0.11, and asymmetry was 5.6 ± 3.5. Normal range of 60 ms instantaneous gain was > 0.73, normal range of regression gain was > 0.80. Abnormal vHIT was found in VS (100%), VN (90.9%), BV (86.7%), MD (40.0%) and ISHL (38.5%). Three conditions of refixation saccades occurred in cases with abnormal VOR: isolated covert saccades (12.5%), isolated overt saccades (45.0%) and the combination of overt and covert saccades (42.5%).

CONCLUSIONSThe vHIT detects abnormal VOR changes in the combination of gain assessment and refixation saccades. Since isolated covert saccades in VOR changes can only be seen with vHIT, peripheral vestibular disorders are likely to be misdiagnosed with the HIT.

Case-Control Studies ; Head Impulse Test ; Hearing Loss, Sudden ; diagnosis ; Humans ; Meniere Disease ; diagnosis ; Neuroma, Acoustic ; diagnosis ; Reflex, Vestibulo-Ocular ; Saccades ; Semicircular Canals ; physiopathology ; Vertigo ; Vestibular Diseases ; diagnosis