1.Risk factors for cardiovascular and cerebrovascular morbidity and mortality in maintenance hemodialysis patients
Huijuan MA ; Hua TANG ; Linsheng LYU ; Yanni WANG ; Caixia WANG ; Xun LIU ; Tanqi LOU
Chinese Journal of Nephrology 2015;31(9):652-657
Objective To identify the risk factors associated with cardiovascular and cerebrovascular disease (CCVD) in maintenance hemodialysis (MHD) patients. Methods We analyzed all of the patients undergoing maintenance hemodialysis in the dialysis center of the 3rd Affiliated Hospital of Sun Yat-sen University for at least 3 months from Jan 1st, 2009 to Dec 31st, 2014. Baseline and yearly interval clinical data were recorded and patients were followed up until morbidity or death of CCVD. Cox proportional hazard regression and time-dependent Cox regression were used to estimate the relative risk of outcomes associated with clinical measurements. Results There were 243 patients enrolled in the study, with a mean age of (53.2 ± 16.4) years old, and 138 of them were male (56.8%). The multivariate Cox proportional model revealed that age (HR=1.040, 95%CI:1.015-1.065, P=0.002), Erythropoietin (EPO) dose (HR=0.914, 95%CI: 0.846-0.987, P=0.022) and history of cardiovascular and cerebrovascular disease (HR=4.045, 95%CI: 2.074-7.890, P<0.001) were independent predictors of CCVD in MHD patients. After adjusting for baseline predictors, time-dependent serum phosphorus level (HR=1.722, 95%CI: 1.034-2.866, P=0.037) was significantly associated with CCVD. Conclusion Older age, decreases in EPO dose and history of cardiovascular and cerebrovascular disease were associated with increased risks of CCVD in MHD patients. Increase in serum phosphorus level was associated with increased risks of CCVD in a time-dependent manner.
2.Depressive symptoms and related factors among primary and middle school students in Changfeng county of Anhui province:a two-year longitudinal study
Xue ZHAO ; Linsheng YANG ; Mingchun CHEN ; Jian CHEN ; Xiaoling LYU ; Yuhong JIANG ; Ying SUN ; Yehuan SUN
Chinese Journal of Epidemiology 2014;(5):505-509
Objective To assess the prevalence of depressive symptoms,trends on its longitudinal development and related influencing factors among primary and middle school students in Changfeng county of Anhui province. Methods Through cluster sampling methods,all students from 3 to 9 grades in 5 primary schools and 3 middle schools in Changfeng county of Anhui province were investigated through questionnaire as subjects of baseline survey in December 2009. Subjects of this longitudinal study were students in grades 3,4 and 7 at the time of the baseline survey and were contacted once a year for two years. At last,a total of 816 students participated in all the three surveys. A structured questionnaire including Children’s Depression Inventory,socio-demographic characteristics and some potential influential factors was employed for this study. A Generalized Estimating Equation (GEE) was used to evaluate the related influencing factors of children’s depressive symptoms in the longitudinal study. Results Prevalence rates of depressive symptoms were 11.3%,10.4% and 8.5%,respectively,at the baseline,1-year and 2-year follow-up studies, among primary and middle school students. Scores on depressive symptoms of total subjects and children who had always been left at home in the follow-up process showed significant differences at the three surveys (F=13.423,P<0.001;F=5.761,P=0.003). 25 percent of the 92 students who showed depressive symptoms at the baseline survey remained those depressive symptoms at the 1-year follow-up study and 87 percent of the 23 students who had depressive symptoms at the baseline and 1-year follow-up surveys still showing depressive symptoms at the 2-year follow-up study. Results from the GEE program indicated that grade 3 students,having syblings,family with dysfunction or at low level of self-esteem etc.,were prone to development while sex and parents’ educational level were not correlated with depressive symptoms. Conclusion Prevalence of depressive symptoms among primary and middle school students in Changfeng county of Anhui province appeared a decreasing tendency during the follow-up process in our study. Through the longitudinal development,we noticed that the prevalence of depressive symptoms seemed to be related to the personal characteristics,education and family environment of the subjects under our study. Improving the level of family function as well as individual’s self-esteem might positively contribute to mental health of those primary and middle school students.
3. Effect of different surgical procedures of parathyroidectomy on secondary hyperparathyroidism: a meta-analysis
Linsheng LYU ; Shaomin LI ; Yuqiu YE ; Wentao HU ; Xun LIU
Chinese Journal of Nephrology 2019;35(12):914-921
Objective:
To evaluate the effect of total parathyroidectomy and autotransplantation (TPTX+AT) and total parathyroidectomy (TPTX) on secondary hyperparathyroidism (SHPT).
Methods:
PubMed, EMBASE and Cochrane library were searched from inception to June 2017 for relative studies, which were screened according to inclusion criteria. Meta-analysis of included study were conducted to compare the improvement of symptoms, persistent SHPT, recurrent SHPT, reoperation, hypoparathyroidism, duration of operation and hospitalization between TPTX+AT group and TPTX group.
Results:
A total of 11 studies with 1212 patients were included. Results of meta-analyses showed no difference between TPTX+AT and TPTX regarding improvement of symptoms and persistent SHPT (
4.Depressive symptoms and related factors among primary and middle school students in Changfeng county of Anhui province:a two-year longitudinal study.
Xue ZHAO ; Linsheng YANG ; Mingchun CHEN ; Jian CHEN ; Xiaoling LYU ; Yuhong JIANG ; Ying SUN ; Yehuan SUN
Chinese Journal of Epidemiology 2014;35(5):505-509
OBJECTIVETo assess the prevalence of depressive symptoms, trends on its longitudinal development and related influencing factors among primary and middle school students in Changfeng county of Anhui province.
METHODSThrough cluster sampling methods, all students from 3 to 9 grades in 5 primary schools and 3 middle schools in Changfeng county of Anhui province were investigated through questionnaire as subjects of baseline survey in December 2009. Subjects of this longitudinal study were students in grades 3, 4 and 7 at the time of the baseline survey and were contacted once a year for two years. At last, a total of 816 students participated in all the three surveys. A structured questionnaire including Children's Depression Inventory, socio-demographic characteristics and some potential influential factors was employed for this study. A Generalized Estimating Equation (GEE) was used to evaluate the related influencing factors of children's depressive symptoms in the longitudinal study.
RESULTSPrevalence rates of depressive symptoms were 11.3% , 10.4% and 8.5% , respectively, at the baseline, 1-year and 2-year follow-up studies, among primary and middle school students. Scores on depressive symptoms of total subjects and children who had always been left at home in the follow-up process showed significant differences at the three surveys (F = 13.423, P < 0.001; F = 5.761, P = 0.003). 25 percent of the 92 students who showed depressive symptoms at the baseline survey remained those depressive symptoms at the 1-year follow-up study and 87 percent of the 23 students who had depressive symptoms at the baseline and 1-year follow-up surveys still showing depressive symptoms at the 2-year follow-up study. Results from the GEE program indicated that grade 3 students, having syblings, family with dysfunction or at low level of self-esteem etc., were prone to development while sex and parents' educational level were not correlated with depressive symptoms.
CONCLUSIONPrevalence of depressive symptoms among primary and middle school students in Changfeng county of Anhui province appeared a decreasing tendency during the follow-up process in our study. Through the longitudinal development, we noticed that the prevalence of depressive symptoms seemed to be related to the personal characteristics, education and family environment of the subjects under our study. Improving the level of family function as well as individual's self-esteem might positively contribute to mental health of those primary and middle school students.
Adolescent ; Child ; China ; epidemiology ; Depression ; epidemiology ; Female ; Follow-Up Studies ; Humans ; Longitudinal Studies ; Male ; Students ; psychology