Objective To search the effective approach of diagnosis for primarygallbladder carcinoma.Methods A retrospective analysis on clincal pathological data was made for 28 cases of primary gallbladdercarcinoma treated in our hospital from April,2002 to August,2007.Results The presenting symptom of 24 patients was right upper abdominal pain and chief complaint of 3 patients was jaundice.The accurate diagnosis rate preoperative was 96.43%.42.86%of the patients was accompanied with gallstone.In this study,the long-term survivor was in Nevin's Stage Ⅱ.The 1-year overal survival rate was 38.46%.Conclusion The primary gallbladdercarcinoma has no typical symptom.The check of imageology is very important.It is important for enhancing early diagnosis rate to pay more attention to the exist of gallbladdercarcinoma and screen patients in acceptable crowd by combining B-mode ultrasonography with tumor markers, such as CA199,CEA,and so on.

Adolescent ; Brain ; pathology ; Child ; Child, Preschool ; Encephalitis, Viral ; diagnosis ; Female ; Humans ; Infant ; Magnetic Resonance Imaging ; methods ; Male ; Retrospective Studies

Background: The incidence of ulcerative colitis (UC) has gradually increased in China in recent years. The pathogenesis of UC is related to the dysfunction of immune system. B7-H5 is an important immune checkpoint molecule and is significant for the regulation of immune function. Ainis: To investigate the expression and clinical significance of B7-H5 in UC. Methods: A total of 65 UC tissue specimens were collected from Jan. 2010 to Dec. 2020 at the First Affiliated Hospital of Soochow University, and 5 healthy subjects were served as controls. Immunohistoehemistry and immunofluorescence were used to detect the expression of B7-H5, and its relationship with elinieopathologieal characteristics of UC patients was analyzed. Results: Expression of B7-H5 was significantly increased in UC patients than in controls (P < 0. 001). B7-H5 expression in UC patients was positively correlated with ESR and CRP (P < 0. 01), but not related to gender, age, extent of lesion, Mayo score and UCEIS score (P > 0. 05). Conclusions; The expression of B7-H5 in UC patients is significantly increased and is correlated with ESR and CRP, and can be used as a new marker for reflecting the severity of inflammation in UC patients.