Objective To understand the incidence of common geriatric syndromes in hospitalized patients,and analyze the relationship between different kinds of geriatric syndromes.Methods A crosssectional study was conducted by five well-trained investigators-300 patients were chosen from geriatric department and medical department within 3 top three hospitals in Chengdu.Results 300 copies of questionnaires were distributed in total,and 300 questionnaires were returned (response rate 100％).Among those,277 questionnaires were considered valid (valid response rate 92.3％).Among those elderly which were above 65 years old,having risk of falling accounted for 91.3％,feeling pain accounted for 79.1％,chronic constipation accounted for 59.2％,having risk of malnutrition accounted for 49.1％,malnutrition accounted for 28.2％,having risk of pressure ulcers accounted for 32.5％,incontinence accounted for 25.3％,and dysphagia accounted for 17％.The correlation among these syndromes was signifcant.Conclusions The overall incidence of geriatric syndromes in hospitalized patients is higher than that in the community.These syndromes are correlated with each other.One can be a risk factor of other geriatric syndromes and also could affect each other.

OBJECTIVEThe objective of this study is to investigate the position change of hyoid bone in obstructive sleep apnea and hypopnea syndrome (OSAHS) induced by oral appliance (OA) of double-pull rods and analyze relevant factors, subsequently investigate treatment mechanism of OA for OSAHS.

METHODSNine OSAHS patients (male), confirmed by polysomnography and excessive daytime sleepiness, were treated with OA of double-pull rods. After a 3-months treatment period, CT scan and three-dimensional reconstruction were made to each patient in central relation with and without OA respectively. The volume of upper airway and hyoid bone position were three-dimensional reconstructed and measured.

RESULTSAfter treatment with OA of double-pull rods, the hyoid bone position was obviously changed in horizontal (5.90 +/- 2.27) mm and vertical position (3.31 +/- 1.82) mm, the volume of upper airway was enlarged (32.36 +/-14.58)%. deltaH-C3hor and deltaH-C3ver were positively related to deltavolume% (r = 0.77, P < 0.05; r = 0.79, P < 0.05), negatively related to FH-MP (r = -0.83, P < 0.05; r = -0.76, P < 0.05).

CONCLUSIONThe hyoid bone position significantly change after using OA of double-pull rods. Patients with smaller FH-MP have larger horizontal change of hyoid bone.

Humans ; Hyoid Bone ; Polysomnography ; Sleep Apnea, Obstructive ; Tomography, X-Ray Computed ; Treatment Outcome

Objective: To compare the chest computed tomography (CT) images of patients with acute respiratory distress syndrome (ARDS) and acute cardiogenic pulmonary edema (ACPE). Methods: 30 cases of patients with ARDS and 30 cases of patients with ACPE from August 2016 to August 2018 were randomly selected. All patients underwent thoracic CT examination. The distributions of grinded glass density shadow (GGO) in the lungs and changes of extrapulmonary structure were statistically analyzed. Results: The differences of distributions of GGO in the upper lobe, middle lobe, lower lobe and diffuse distribution between patients with ARDS and ACPE were not significant [16.7%(5/30), 0, 16.7%(5/30), 66.7%(20/30) vs 20.0%(6/30), 0, 20.0%(6/30), 60.0%(18/30), P>0.05]. The distributions of GGO in center lung [13.3%(4/30)] was significantly lower than patients with ACPE [46.7%(14/30)] (P<0.05), while the uniform distribution rate [76.7%(23/30)] was significantly higher than patients with ACPE [46.7%(14/30)] (P<0.05), but distribution of GGO in the right side, left side, bilateral even in peripheral distribution of GGO in lung between patients with ARDS and ACPE were not significant [10.0%(3/30), 6.7%(2/30), 16.7%(5/30), 23.3%(7/30), 60.0%(18/30) vs 23.3%(7/30), 16.7%(5/30) and 60.0%(18/30), P>0.05]. The small boundary opacity of patients with ARDS [76.7%(23/30)] was significantly higher than patients with ACPE [26.7%(8/30)] (P<0.05), while the bronchial blood bundle thickening, pulmonary vascular shadow thickening, cardiac shadow enlargement, pericardial effusion were significantly lower than patients with ACPE [33.3% (10/30), 16.7%(5/30), 30.0%(9/30), 23.3%(7/30) vs 23.3%(7/30), 100.0%(30/30), 70.0%(21/30), 73.3%(22/30), 53.3%(16/30), P<0.05]. Conclusions The chest CT images of patients with ARDS and ACPE are different, mainly manifestated in small boundary opacity, bronchial blood bundle thickening, pulmonary vascular opacity, cardiac opacity, pericardial effusion.

Objective The number of children diagnosed with autism spectrum disorder (ASD)has increased dramatically in the past years.Parents of children with ASD usually experience a variety of chronic and acute stressors that may decrease marital satisfaction and family functioning.The aim was to explore the characteristics of parental per-sonality,mood disorders and family functions of the Children with ASD and to explore the relevance factors in order to draw out methods to improve parental family functions.Methods A cross -sectional survey was conducted and 593 outpatients with ASD diagnosed in Shanghai Mental Health Center,Shanghai Jiao Tong University School of Medicine form January 201 0 to January 201 4 were straight into the group,their parents were tested by Family Assessment Device (FAD),Zung Self -Rating Depression Scale(SDS),Zung Self -Rating Anxiety Scale(SAS)and Eysenck Personality Questionnaire(EPQ).SPSS 1 7.0 software was adopted to establish the database and statistical analysis.Results Ac-cording to FAD,parents of children with ASD had lower scores in problem solving[(2.1 0 ±0.37)scores]and roles [(2.09 ±0.27)scores](t =-6.669,P =0.000;t =-1 8.707,P =0.000)than the standard scores,while other di-mensions score were significantly higher than the standard scores in communicdtion[(2.25 ±0.35)scores],emotional reaction[(2.38 ±0.40)scores],emotional involvement[(2.36 ±0.37)scores],behavioral control[(2.31 ±0.27) scores]and general function[(2.1 2 ±0.38)scores],there were significant differences(t =3.1 35,1 1 .1 1 5,1 6.997, 37.1 1 6,8.064;P =0.002,0.000,0.000,0.000,0.000).For EPQ of parents,mother had obviously higher scores than father in psychoticism scale[(53.68 ±1 .36)scores vs (52.65 ±1 .1 7)scores,t =-1 3.841 ,P =0.000],and signifi-cantly lower scores in Lie scale[(52.27 ±0.79)scores vs (52.1 7 ±0.75)scores,t =2.449,P =0.01 4].Compared to fathers,mothers were coded as higher depression and anxiety scores(t =-6.276,-6.440,all P =0.000)and higher prevalence rate(χ2 =1 5.893,27.592,all P =0.000),which were statistically significant.According to the asso-ciation study of FAD and the others(especially in mood of parents),it was found that several dimensions showed obvious correlation.Conclusions Parents of children with ASD have family function damaged badly,except for prob-lem solving and roles.The parents showed different personality traits and mood disorders,particularly mothers′mood disorder problem was prominent.Parental family functioning were closely related to their personality traits and emotional disorders in various dimensionalities,which was worthy of attention.

ObjectiveTo explore the correlation of sleep quality with negative life events and coping styles in adolescents based on structural equation modeling， and to provide references for improving the adolescents' sleep quality. MethodsFrom December 2021 to May 2022， a total of 767 junior middle school students from three schools in Chongqing were enrolled， and assessed using Pittsburgh Sleep Quality Index （PSQI）， Adolescent Self-rating Life Events Checklist （ASLEC） and Simplified Coping Style Questionnaire （SCSQ）. Then the structural equation model was applied to discuss the correlation of sleep quality with negative life events and coping styles in adolescents. ResultsA total of 222 adolescents （28.94%） were found to have sleep disorders. PSQI score was positively correlated with ASLEC score and negative coping dimension score of SCSQ （r=0.612， 0.590， P<0.01）， and negatively correlated with positive coping dimension score of SCSQ （r=-0.435， P<0.01）. The structural equation model of the relationship between negative life events， coping styles and sleep quality denoted that negative life events exhibited both direct and indirect positive effects on sleep quality （β=0.448， 0.322， P<0.05）， positive coping style had direct negative effects on sleep quality （β=-0.368， P<0.05）， and negative coping style had direct positive effects on sleep quality （β=0.442， P<0.05）. ConclusionNegative life events and negative coping style cause adverse effects on adolescents' sleep quality， while positive coping style exerts positive effects on adolescents' sleep quality.

EGFR tyrosine kinase inhibitor (EGFR-TKI) has been used successfully in clinic for the treatment of solid tumors. In the present study, we reported the discovery of from our in-house diverse compound library, which was validated to be a potent and selective EGFR-TKI. showed excellent inhibitory activities against EGFR (IC = 0.81 nmol/L), EGFR (IC = 1.2 nmol/L) and EGFR (IC = 1.1 nmol/L), but was less effective or even inactive against other nine kinases. also displayed excellent antiproliferative activities against a panel of human cancer cell lines, and exhibited the ability to reduce colony formation and wound healing the same as gefitinib. We found that upon oral administration showed better anti-tumor activity in A431 bearing xenograft mouse models compared to gefitinib. In addition, showed better intestinal absorption than gefitinib and had favorable pharmacokinetic properties and microsomal metabolic stability in different species. These studies indicate that has strong antitumor activity and , and could be used for the development of anti-lung cancer agent targeting EGFR.