1.Manage the hospital with morals
Chinese Medical Ethics 1995;0(02):-
In order to push implement compendium of citizen moral construction in hospital,we establish and issue "implement constitution of moral construction of medical workers". In order to carry out constitution better,strong criterion construction of hospital moral,strong constitution construction of hospital,strong collectivism thought of employee,strong multiple medical practient activity,strong some acts to maintain patient rights and interests.
2.Standard with Professional Moral, Improve Service Level of Arechives
Shuxin JIA ; Mingsheng ZHU ; Linjing SHAO
Chinese Medical Ethics 1995;0(02):-
The artice sets forth the standard of hospital archives moral. It sets forth to abide professional moral standard scrupulously,surrounds with "Life Line" engineering construction,the main task of our hospital,and propagandize & education to work hard.
3.Effect of salidroside on activity of endothelial progenitor cells and phos-phoinositide 3-kinase/Akt signaling pathway
Zhilan ZHOU ; Linjing WANG ; Gexiu LIU ; Jincan ZHU ; Xiaoyu CHEN ; Shantao LIU
Chinese Journal of Pathophysiology 2014;(7):1192-1195
AIM: To investigate whether salidroside has influence on the activities of endothelial progenitor cells (EPCs) and its mechanism.METHODS:Mononuclear cells from normal human peripheral blood were cultured in fi-bronectin coated flasks in endothelial progenitor medium .After 7 d, EPCs were characterized as adherent cells with acLDL-DiI uptaking and lectin binding by direct fluorescent staining .The proliferation and migration of EPCs were analyzed by MTT assay and Transwell chamber assay , respectively.The EPCs adhesion assay was performed by re-plating the cells on fibronectin-coated dishes , and then adherent cells were counted .NO and Akt protein were also detected .RESULTS:Sali-droside promoted EPCs proliferative , migratory and adhesive capacities in a concentration dependent manner .Salidroside also increased NO secretion , and the level of phosphorylated Akt protein .However , the effects of salidroside on EPCs were inhibited by phosphoinositide 3-kinase inhibitor LY294002.CONCLUSION:Salidroside regulates the activity of EPCs by phosphoinositide 3-kinase/Akt signaling pathway .
4.Application of aerosol inhalation of esketamine combined with Ⅰ-gel laryngeal mask and Wellead occluder in single lung ventilation
Aiming CHEN ; Xiaoxue ZHU ; Jianfei YU ; Linjing SUN
The Journal of Clinical Anesthesiology 2023;39(11):1173-1177
Objective To investigate the effectiveness of esketamine aerosol inhalation combined with Ⅰ-gel laryngeal mask and Wellead bronchial occluder for thoracoscopic single lung ventilation surgery.Methods Seventy-five thoracic surgery patients,39 males and 36 females,aged 28-64 years,BMI 18-25 kg/m2,ASA physical status Ⅰ or Ⅱ,were selected for thoracoscopic surgery.Patients were randomly di-vided into three groups by digital table method:esketamine nebulizing inhalation combined with Ⅰ-gel laryn-geal mask and Wellead bronchial sealer group(group EW),Ⅰ-gel laryngeal mask combined with Wellead bronchial sealer group(group LW),and tracheal catheter combined with Wellead bronchial sealer group(group TW),25 cases in each group.The insertion time,extraction time,awakening time,and the highest PETCO2 value during single lung ventilation were recorded in the three groups.Airway peak pressure(Ppeak)and dynamic lung compliance(Cdyn)were recorded during 15 minutes of supine double-lung ven-tilation and 15 minutes of lateral single-lung ventilation.The changes of tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),interleukin-8(IL-8)and other inflammatory factors in alveolar lavage fluid at 10 mi-nutes before single lung ventilation(T0),10(T1),30(T2),60 minutes(T3)after single lung ventila-tion,and at the end of single lung ventilation(T4),lung collapse score on the operative side,postoperative coughing,hoarseness,sore throat,and atelectasis occurred.Results Compared with group TW,the ex-traction time and awakening time of groups EW and LW were significantly shortened(P<0.05),Ppeak was significantly decreased and Cdyn was significantly increased in group EW during double lung and single lung ventilation(P<0.05),and Ppeak was significantly decreased and Cdyn was significantly increased in group LW during single lung ventilation(P<0.05),TNF-α,IL-6 and IL-8 were significantly decreased at T2-T4 in groups EW and LW(P<0.05),and the incidence of cough and throat pain was significantly de-creased(P<0.05).Compared with group LW,Ppeak and Cdyn were significantly decreased in group EW during double lung and single lung ventilation(P<0.05),and TNF-α,IL-6,and IL-8 were significantly decreased at T2-T4(P<0.05).There were no significant differences in the insertion time,the highest val-ue of PET CO2 and the lung collapse score among the three groups,and no case of atelectasis occurred among the three groups.Conclusion The use of esketamine aerosol inhalation combined with Ⅰ-gel laryngeal mask and Wellead bronchial occluder for thoracoscopic surgery can ensure the required ventilation during surgery,significantly reduce airway irritation during general anesthesia induction and recovery,reduce pneumonia re-action,and improve lung compliance,which is worthy of clinical promotion.
5.Application of microfluidics in anti-infectious immunity
Boyang LIU ; Linjing ZHU ; Fang FANG ; Yan QI ; Xueling CUI
Chinese Journal of Microbiology and Immunology 2024;44(1):34-38
The immune response against infection is a multifaceted process encompassing the activation and migration of diverse immune cells, as well as the clearance of pathogens. The behaviors of immune cells and the identification of pathogens play pivotal roles as indicators for disease diagnosis and prediction. In recent years, the utilization of microfluidic chip technology has gained substantial attention within the areas of biology, pharmacology, and clinical research and diagnosis. This is primarily attributed to the numerous advantages it offers, including miniaturization, enhanced throughput, heightened sensitivity, expedited analysis, and reduced sample consumption. As a result, microfluidic technology has facilitated the development and utilization of immune cell behavioral assays, bacterial growth studies, and drug-screening assays. This paper is to review the application of microfluidic technology in the field of anti-infection immunity research, focusing on the analysis of migratory behavior of innate immune cells, deformation of their nuclei, and rapid identification of pathogenic bacteria and viruses. The primary objective of this review is to advance the application of microfluidic technology in research on both anti-infection immunity and clinical diagnosis.