OBJECTIVE:To provide suggestions for retail drugstores on how to tackle problems of non-quality induced drug returning from customers.METHODS:Reasons why it is hard to return the already purchased drugs were analyzed based on the status quo of drug returning in retail drugstores,and some countermeasures were presented on how to reduce or avoid non-quality induced drug returning problems.RESULTS&CONCLUSION:Non-quality induced drug returning problems can be well solved in drugstores through improving pharmaceutical care level and management level.

OBJECTIVE:To provide the reference for drug stores to choose the chain mode:the direct sales or franchise.METHODS:The common modes of the drug store’chain administration and the current condition of the chain drug store industry in china were summarized;The merits&demerits of each mode and the environment,which influenced the choice of chain modes,were analyzed.RESULTS&CONCLUSION:The phenomenon can not be the proof that direct sales are better than the franchise in the market.The Chinese pharmaceutical chain enterprises should make their own choices based on the specific situation.The improved franchise mode is very competitive in the market.

Objective:To observe the theraputic effect and changes of glomerular extracellular matrix components(ECM) and PAI-1 and their relationships after cure with methyl-prednisone on immune complexes nephritis rats.Methods:Immune complexes nephritis rats model were induced with C-BSA.Levels of FN,LN in different treatment groups were analyzed by ELISA, level of PAI-1 in rats renal tissue was determined by color developing substrate,was theraputic effect of methyl-prednisone with 24 hours volumes of urine protein.Results:The levels of PAI-1,FN and LN of model groups were significantly higher than those of normal and control groups,and PAI-1 was significantly correlated with LN and FN,Glomerular mesangial matrix proliferated slightly and moderately;The levels of FN,LN and PAI-1 decreased signifcantly and glomerular mesangial matrix proliferation lessen differently after cure of methyl-prednisone for 1 and 2 weeks,but not reaching the level of normal groups;24 hours volumes of urine protein decrease significantly in treatment groups.Conclusion:The ECM accumulation correlate with PAI-1 increase in immune complexes rats,methyl-prednisone may affect ECM accumulation by interfering with PA/PAI-1 system to reach a treatment purpose.

Objective:To study the mechanism of immune tolerance induce by protal venous injection of donor spleen cells on the dog model of renal transplantation.Methods:The donor spleen cells were injected through the protal vein during operation,one week later,renal transplantation was performed.IL-2 and IL-6 were studied by method of ELISA.Results:Level of IL-2 and IL-6 in protal venous group and cyclosporin group was higher than that of control group.There were no difference between protal venous group and cyclosporin group.Conclusion:Immune tolerance could be produced by protal venous injection of donor spleen cells.

ObjectiveTo compare the effects of airway humidification by atomization humidifier and heated humidifier on ICU patients with tracheotomy. Methods? Totally 57 patients who received tracheotomy and did not need mechanical ventilation from the Department of Critical Care Medicine of Yixing No.2 People's Hospital between December 2014 and November 2017 were selected by convenient sampling and divided into the control group (n=28) which received airway humidification by atomization humidifier and the observation group (n=29) which received airway humidification by heated humidifier according to the random number table. The differences in sputum quantity, number of daily sputum suction, sputum viscosity and blood gas analysis index were compared between the two groups. Results? The number of daily sputum suction, sputum volume and viscosity of sputum of the observation group were less than that of the control group (P＜0.05). The observation group showed better blood gas analysis results than the control group on day 7 (P＜0.05). Conclusions? The heated humidifier is better for dilution and drainage of sputum. It can effectively improve the oxygenation of ICU patients with tracheotomy, maintain better acid-base balance, lessen sputum suction procedures which would be repeated and time-consuming in clinical nursing care, reduce damage to patients' airway mucosa, and improve the quality of airway management, which is worth promoting in clinical practice.