ObjectiveTo optimize the processing technology of honey bran-fried Rosae Laevigatae Fructus（h-RLF）， formulate relevant quality standards， and explore its improving effect and mechanism on mice with ulcerative colitis（UC） induced by dextran sodium sulfate（DSS）. MethodsTaking the content of polysaccharides and water-soluble extract as the indexes， L₉（3⁴） orthogonal test was used to optimize parameters of the amount of honey bran， frying time and frying temperature. The quality of 15 batches of h-RLF decoction pieces was evaluated according to the optimized process， and the inspection limit standard was preliminarily drawn up. Eighty SPF male Kunming mice were randomly divided into 8 groups， including the blank group， model group， mesalazine group（0.13 g·kg^-1）， RLF group（3.77 g·kg^-1）， bran-fried RLF group（3.77 g·kg^-1）， h-RLF low， medium and high dose groups（1.89， 3.77， 7.54 g·kg^-1）， with 10 mice in each group. The mice in the blank group were free to drink pure water， and the other groups were free to drink 3% DSS solution for 7 days to prepare UC mouse model. Each treatment group was given corresponding drugs by intragastric administration， and the blank and model groups were given equal volume of normal saline. The body weight of mice was recorded daily and the disease activity index（DAI） was calculated. After the administration， the colon tissues of mice were collected to observe the pathological changes by hematoxylin-eosin（HE） staining. The levels of tumor necrosis factor（TNF）-α， interleukin（IL）-1β， IL-6 and IL-10 in the colon of mice were detected by enzyme-linked immunosorbent assay（ELISA）. Western blot was used to detect the expression levels of phosphorylation nuclear transcription factor-κB p65（p-NF-κB p65）， Toll-like receptor 4（TLR4）， p-p38 mitogen-activated protein kinase（p-p38 MAPK）， p-extracellular signal-regulated kinase（p-ERK） and p-c-Jun N-terminal kinase（p-JNK） proteins in colon tissues. ResultsThe optimum processing technology of h-RLF was 20 g honey bran per 100 g RLF， and stir-frying at 200 ℃ for 8 min. The limit standard under the examination of h-RLF was preliminarily formulated as follows：the polysaccharide content should not be less than 25% based on anhydrous glucose（C₆H₁₂O₆）， the content of water-soluble extract should not be less than 38%， the moisture content should not be more than 12.0%， the total ash content should not be more than 5.0%， and the acid-insoluble ash content should not be more than 1.0%. The cluster heat map analysis showed that the quality of RLF from Huanggang， Hubei province was better. Animal experiments showed that compared with the blank group， the DAI score of the model group was significantly increased， the levels of TNF-α， IL-1β and IL-6 in the colon tissue were significantly increased， the IL-10 level was significantly decreased， the colonic mucosa was seriously damaged， accompanied by a large number of inflammatory cell infiltration， tissue congestion and a significant reduction in glands， and the expression levels of p-NF-κB p65， TLR4， p-p38 MAPK， p-ERK and p-JNK proteins were significantly increased（P<0.01）. Compared with the model group， each administration group could alleviate the symptoms of colonic ulcer， the structure of colonic crypt was basically intact， and the glands were arranged in an orderly manner. Among them， the high-dose group of h-RLF had a better effect， which could significantly reduce the DAI score and the levels of TNF-α， IL-1β and IL-6 in colon tissue（P<0.01）， and significantly increase the level of IL-10（P<0.01）， alleviate the colonic mucosal injury， and effectively inhibit the expression levels of p-NF-κB p65， TLR4， p-p38 MAPK， p-ERK and p-JNK proteins（P<0.01）. ConclusionThe key parameters of the processing technology of h-RLF are determined， and the optimized technology is stable and feasible. The established quality standard is simple and reliable， and can be used for the quality control. h-RLF can effectively alleviate DSS-induced UC， and its mechanism may be related to inhibiting the activation of NF-κB/TLR4/MAPK pathway.

At present, liver transplantation is the most effective method for the treatment of various end-stage liver diseases, and electronic health technology is a new medical service model, which can be used as an efficient and cost-effective alternative to the health management of liver transplant recipients. This paper summarizes the application of electronic health technology in postoperative health management of liver transplant recipients, including applications, robots, video conferencing, tablet computers, text messages, telephones and wearable devices, etc., summarizes the implementation effect of electronic health technology in health management of liver transplant recipients, and analyzes the limitations of research and application at the present stage. In order to provide basis and reference for Chinese medical staff to carry out electronic health technology in the health management of liver transplant recipients.

Objective:To investigate the effects of backward walking observational training combined with Soundsory cognitive training based on PASS (P: planning; A: attention; S: simultaneous; S:successive) theory on cognitive function, balance function and self-efficacy in elderly patients with post-stroke mild cognitive impairment (MCI).Methods:A randomized controlled trial was conducted. Elderly patients with post-stroke MCI admitted to the Department of Neurology, Affiliated Hospital of Jiangnan University from December 2022 to November 2023 were selected as the study objects by convenience sampling method. The patients were divided into control group and observation group by random number table. The patients in the control group implemented routine care and rehabilitation training, while the observation group were implemented backward walking observational training combined with Soundsory cognitive training based on the PASS theory. The Montreal Cognitive Assessment (MoCA), the Brunel Balance, and the Stroke Self-Efficacy Questionnaire (SSEQ) were used to evaluate the intervention effect before intervention, 2 weeks and 4 weeks of intervention, respectively.Results:A total of 116 elderly patients with post-stroke MCI were included, comprising 58 patients in the observation group (32 males and 26 females), aged (73.47 ± 7.10) years, and 58 patients in the control group (33 males and 25 females), aged (72.72 ± 8.37) years. Before intervention, there were no significant differences in the total scores of MoCA, SSEQ and Brunel Balance Scale between the 2 groups (all P>0.05). At 2 and 4 weeks of intervention, the total score of MoCA in the observation group were (20.10 ± 2.73), (22.98 ± 2.98) points, which were higher than those of the control group (18.24 ± 2.84), (20.47 ± 3.29) points, the differences were statistically significant ( t=3.61, 4.32, both P<0.05). The total score of SSEQ in the observation group were (49.97 ± 7.73), (54.98 ± 7.88) points, which were higher than those in the control group (46.50 ± 8.69), (51.59 ± 6.10) points, the differences were statistically significant ( t=2.27, 2.60, both P<0.05). At 4 weeks of intervention, the Brunel Balance Scale score in the observation group was 11(9, 11) points, which was higher than 10(8, 11) points in the control group, the difference was statistically significant ( Z=-2.00, P<0.05). Conclusions:Backward walking observational training combined with Soundsory cognitive training based on PASS theory can effectively improve cognitive and balance functions, and enhance self-efficacy in elderly patients with post-stroke MCI.

The symptom clusters increase the symptom distress of liver transplant recipients, reduces their treatment and nursing compliance, and greatly affects the prognosis quality of life of liver transplant recipients. This article reviews the concept, research status, assessment tools, influencing factors, and interventions for symptom clusters in liver transplant recipients, aiming to help clinical nurses formulate targeted interventions based on symptom clusters, provide effective symptom management for liver transplant recipients, reduce the physical and psychological damage caused by symptom clusters, and continuously improve the quality of life of liver transplant recipients.

Objective:To investigate the effects of ultrasound-guided intermuscular brachial plexus anesthesia on shoulder arthroscopic surgery.Methods:A total of 300 patients who underwent shoulder arthroscopic surgery at Dongyang Hospital of Traditional Chinese Medicine from January 2022 to January 2023 were prospectively included in this study. A randomized controlled trial design was used. The patients were divided into an observation group ( n = 150) and a control group ( n = 150) using a random number table method. The control group received intravenous general anesthesia, while the observation group underwent intermuscular brachial plexus nerve block combined with intravenous general anesthesia. The clinical efficacy, surgical indicators, hemodynamic levels, and incidence of adverse reactions were compared between the two groups. Results:The Visual Analog Scale (VAS) scores and the muscle strength scores for elbow and wrist flexion in the observation group at 2 and 3 h postoperatively were (4.12 ± 0.21), (2.32 ± 0.62), (3.35 ± 0.61), and (4.19 ± 0.57), respectively. There values were significantly superior to those in the control group [(6.54 ± 0.32), (1.21 ± 0.23), (4.62 ± 0.21), (3.25 ± 0.63), t = 77.44, 20.56, -24.11, 13.55, all P < 0.01]. The intraoperative lavage fluid volume, remifentanil dosage, propofol dosage, and duration of surgery in the observation group were (6.32 ± 2.11) L, (0.13 ± 0.03) μg·kg?1·min?1, (0.11 ± 0.03) mg·kg?1·h?1, and (73.23 ± 15.86) min, respectively, all of which were significantly lower than those in the control group [(8.52 ± 3.23) L, (0.15 ± 0.02) μg·kg?1·min?1, (0.15 ± 0.02) mg·kg?1·h?1, and (79.88 ± 15.56) min, t = 6.98, -6.79, -13.59, -3.67, all P < 0.01]. The clarity of the surgical field in the observation group was rated at (1.02 ± 0.21) points, which was significantly higher than that in the control group [(1.75 ± 0.32) points, t = -23.36, P < 0.01]. At the start of surgery (T1) and 30 min into the procedure (T2), the systolic blood pressures in the observation group were (106.65 ± 7.12) mmHg (1 mmHg = 0.133 kPa) and (97.02 ± 5.01) mmHg, which were significantly lower than those in the control group [(108.69 ± 7.21) mmHg, (98.26 ± 5.12) mmHg, t = -2.47, -2.12, both P < 0.05]. The heart rates in the observation group at T1, T2, 60 min into the procedure (T3), and 10 min post-extubation (T4) were (71.69 ± 5.32) beats/min, (62.32 ± 4.85) beats/min, (61.12 ± 4.25) beats/min, and (79.28 ± 3.52) beats/min, all of which were significantly lower than those in the control group [(91.23 ± 5.21) beats/min, (90.12 ± 4.63) beats/min, (92.21 ± 4.31) beats/min, (92.32 ± 3.51) beats/min, t = -32.14, -50.78, -62.91, -32.13, all P < 0.01]. The total incidence of adverse reactions, including allergies, nausea, vomiting, and dizziness, in the observation group was 28.67% (43/150), which was significantly lower than that in the control group [45.33% (68/150), χ2 = 8.94, P < 0.01]. Conclusions:Ultrasound-guided intermuscular brachial plexus anesthesia improves intraoperative anesthetic effects, reduces the volume of lavage fluid, remifentanil, and propofol used, shortens duration of surgery, and enhances the clarity of the surgical field. Additionally, it also effectively controls blood pressure and hemodynamic changes, leading to a reduction in adverse reactions.

Objective In this study,the potential profile characteristics of exercise self-efficacy of patients with inflammatory bowel disease(IBD)were explored,and the influencing factors of different types of patients were an-alyzed,so as to provide a reference for nurses to formulate standardized management measures.Methods From June 2023 to May 2024,a total of 342 hospitalized patients with IBD in tertiary A hospital in Wuxi were recruited as research subjects by a convenience sampling method.The General Information Questionnaire,Exercise Self-effica-cy Scale,Exercise Behavioral Stage Distribution Scale and the Social Support Rating Scale were used for investiga-tion.The latent profile analysis was conducted to classify exercise self-efficacy levels,while multiple Logistic regres-sion analysis was utilized to evaluate the influencing factors.Results A total of 320 valid questionnaires were col-lected,and the effective questionnaire recovery rate was 93.57％.The total score of exercise self-efficacy for IBD pa-tients was(64.61±14.83)points.The exercise self-efficacy was classified into 3 latent categories:low efficacy-somatic emotion group(n=64,20.00％),medium efficacy-work conflict group(n=158,49.38％),and high efficacy-social interfer-ence group(n=98,30.62％).Occupation,recurrence times,comorbid chronic diseases,self-assessed economic pressure,and social support level were found to be influencing factors of the latent profile classification of exercise self-effi-cacy in IBD patients(P＜0.05).Conclusion The levels of exercise self-efficacy of patients with IBD are significant-ly heterogeneous,and there are several important influencing factors.Nursing staff should formulate targeted inter-vention strategies based on the characteristics of exercise self-efficacy in such patients,so as to improve patients' exercise self-efficacy and the effectiveness of disease rehabilitation.

At present, liver transplantation is the most effective method for the treatment of various end-stage liver diseases, and electronic health technology is a new medical service model, which can be used as an efficient and cost-effective alternative to the health management of liver transplant recipients. This paper summarizes the application of electronic health technology in postoperative health management of liver transplant recipients, including applications, robots, video conferencing, tablet computers, text messages, telephones and wearable devices, etc., summarizes the implementation effect of electronic health technology in health management of liver transplant recipients, and analyzes the limitations of research and application at the present stage. In order to provide basis and reference for Chinese medical staff to carry out electronic health technology in the health management of liver transplant recipients.

Objective:To investigate the effects of backward walking observational training combined with Soundsory cognitive training based on PASS (P: planning; A: attention; S: simultaneous; S:successive) theory on cognitive function, balance function and self-efficacy in elderly patients with post-stroke mild cognitive impairment (MCI).Methods:A randomized controlled trial was conducted. Elderly patients with post-stroke MCI admitted to the Department of Neurology, Affiliated Hospital of Jiangnan University from December 2022 to November 2023 were selected as the study objects by convenience sampling method. The patients were divided into control group and observation group by random number table. The patients in the control group implemented routine care and rehabilitation training, while the observation group were implemented backward walking observational training combined with Soundsory cognitive training based on the PASS theory. The Montreal Cognitive Assessment (MoCA), the Brunel Balance, and the Stroke Self-Efficacy Questionnaire (SSEQ) were used to evaluate the intervention effect before intervention, 2 weeks and 4 weeks of intervention, respectively.Results:A total of 116 elderly patients with post-stroke MCI were included, comprising 58 patients in the observation group (32 males and 26 females), aged (73.47 ± 7.10) years, and 58 patients in the control group (33 males and 25 females), aged (72.72 ± 8.37) years. Before intervention, there were no significant differences in the total scores of MoCA, SSEQ and Brunel Balance Scale between the 2 groups (all P>0.05). At 2 and 4 weeks of intervention, the total score of MoCA in the observation group were (20.10 ± 2.73), (22.98 ± 2.98) points, which were higher than those of the control group (18.24 ± 2.84), (20.47 ± 3.29) points, the differences were statistically significant ( t=3.61, 4.32, both P<0.05). The total score of SSEQ in the observation group were (49.97 ± 7.73), (54.98 ± 7.88) points, which were higher than those in the control group (46.50 ± 8.69), (51.59 ± 6.10) points, the differences were statistically significant ( t=2.27, 2.60, both P<0.05). At 4 weeks of intervention, the Brunel Balance Scale score in the observation group was 11(9, 11) points, which was higher than 10(8, 11) points in the control group, the difference was statistically significant ( Z=-2.00, P<0.05). Conclusions:Backward walking observational training combined with Soundsory cognitive training based on PASS theory can effectively improve cognitive and balance functions, and enhance self-efficacy in elderly patients with post-stroke MCI.

The symptom clusters increase the symptom distress of liver transplant recipients, reduces their treatment and nursing compliance, and greatly affects the prognosis quality of life of liver transplant recipients. This article reviews the concept, research status, assessment tools, influencing factors, and interventions for symptom clusters in liver transplant recipients, aiming to help clinical nurses formulate targeted interventions based on symptom clusters, provide effective symptom management for liver transplant recipients, reduce the physical and psychological damage caused by symptom clusters, and continuously improve the quality of life of liver transplant recipients.

Objective:To investigate the effects of ultrasound-guided intermuscular brachial plexus anesthesia on shoulder arthroscopic surgery.Methods:A total of 300 patients who underwent shoulder arthroscopic surgery at Dongyang Hospital of Traditional Chinese Medicine from January 2022 to January 2023 were prospectively included in this study. A randomized controlled trial design was used. The patients were divided into an observation group ( n = 150) and a control group ( n = 150) using a random number table method. The control group received intravenous general anesthesia, while the observation group underwent intermuscular brachial plexus nerve block combined with intravenous general anesthesia. The clinical efficacy, surgical indicators, hemodynamic levels, and incidence of adverse reactions were compared between the two groups. Results:The Visual Analog Scale (VAS) scores and the muscle strength scores for elbow and wrist flexion in the observation group at 2 and 3 h postoperatively were (4.12 ± 0.21), (2.32 ± 0.62), (3.35 ± 0.61), and (4.19 ± 0.57), respectively. There values were significantly superior to those in the control group [(6.54 ± 0.32), (1.21 ± 0.23), (4.62 ± 0.21), (3.25 ± 0.63), t = 77.44, 20.56, -24.11, 13.55, all P < 0.01]. The intraoperative lavage fluid volume, remifentanil dosage, propofol dosage, and duration of surgery in the observation group were (6.32 ± 2.11) L, (0.13 ± 0.03) μg·kg?1·min?1, (0.11 ± 0.03) mg·kg?1·h?1, and (73.23 ± 15.86) min, respectively, all of which were significantly lower than those in the control group [(8.52 ± 3.23) L, (0.15 ± 0.02) μg·kg?1·min?1, (0.15 ± 0.02) mg·kg?1·h?1, and (79.88 ± 15.56) min, t = 6.98, -6.79, -13.59, -3.67, all P < 0.01]. The clarity of the surgical field in the observation group was rated at (1.02 ± 0.21) points, which was significantly higher than that in the control group [(1.75 ± 0.32) points, t = -23.36, P < 0.01]. At the start of surgery (T1) and 30 min into the procedure (T2), the systolic blood pressures in the observation group were (106.65 ± 7.12) mmHg (1 mmHg = 0.133 kPa) and (97.02 ± 5.01) mmHg, which were significantly lower than those in the control group [(108.69 ± 7.21) mmHg, (98.26 ± 5.12) mmHg, t = -2.47, -2.12, both P < 0.05]. The heart rates in the observation group at T1, T2, 60 min into the procedure (T3), and 10 min post-extubation (T4) were (71.69 ± 5.32) beats/min, (62.32 ± 4.85) beats/min, (61.12 ± 4.25) beats/min, and (79.28 ± 3.52) beats/min, all of which were significantly lower than those in the control group [(91.23 ± 5.21) beats/min, (90.12 ± 4.63) beats/min, (92.21 ± 4.31) beats/min, (92.32 ± 3.51) beats/min, t = -32.14, -50.78, -62.91, -32.13, all P < 0.01]. The total incidence of adverse reactions, including allergies, nausea, vomiting, and dizziness, in the observation group was 28.67% (43/150), which was significantly lower than that in the control group [45.33% (68/150), χ2 = 8.94, P < 0.01]. Conclusions:Ultrasound-guided intermuscular brachial plexus anesthesia improves intraoperative anesthetic effects, reduces the volume of lavage fluid, remifentanil, and propofol used, shortens duration of surgery, and enhances the clarity of the surgical field. Additionally, it also effectively controls blood pressure and hemodynamic changes, leading to a reduction in adverse reactions.