Objective:To investigate the value of virtual touch tissue imaging quantitative (VTIQ) combined with serum thymidine kinase 1 (TK1) detection in predicting the recurrence of triple negative breast cancer (TNBC) after breast preservation surgery.Methods:A total of 102 TNBC patients admitted to our hospital from May. 2020 to Apr. 2022 who underwent elective breast-preserving surgery were selected as the study objects. VTIQ was examined after surgery, shear wave velocity (SWV) was measured, and serum TK1 was detected. All patients were followed up after surgery, and tumor recurrence two years after surgery was statistically analyzed. Multivariate Logistic regression analysis was used to explore the influencing factors of tumor recurrence after TNBC breast-preserving preservation, and ROC curve was drawn to analyze the predictive value of SWV and serum TK1 levels on tumor recurrence.Results:The tumor recurrence rate of 102 TNBC patients was 29.41% (30/102) at 2 years after breast-preserving surgery. The TNM stage, lymph node metastasis, the levels of SWV and TK1 in the relapsed group were higher ( χ2=4.42, χ2=6.41, t=6.97, t=6.15, all P<0.05). Multivariate Logistic regression analysis showed that lymph node metastasis, SWV and serum TK1 level were influential factors for tumor recurrence at 2 years after breast-preserving surgery in TNBC patients ( OR=3.093, OR=3.501, OR=2.939, all P<0.05). ROC curve analysis showed that the AUC values of SWV and serum TK1 levels and their combined detection in predicting tumor recurrence after breast-preserving in TNBC patients were 0.821, 0.778 and 0.869, respectively, the sensitivity was 66.67%, 73.33% and 83.33%, respectively, and the specificity was 81.94%, 76.39% and 79.17%, respectively. The combined detection of SWV and serum TK1 level was more effective than the single detection in predicting tumor recurrence in patients with TNBC after breast-preserving surgery. Conclusion:SWV and serum TK1 levels are related to tumor recurrence after TNBC, and can predict tumor recurrence, and the combined detection of the two indicators can improve the prediction efficiency of tumor recurrence after TNBC.

Objective:To explore the correlations between caregiving burden, psychological resilience and acceptance of caregivers of patients with Alzheimer disease.Methods:Using the convenient sampling method, a total of 140 caregivers of patients with Alzheimer disease who visited outpatient department of Department of Geriatrics and Neurology of Xiangya Hospital of Central South University were selected as research objects from February 2019 to August 2020. Caregivers Burden Inventory (CBI) , Connor-Davidson Resilience Scale (CD-RISC) and Acceptance and Action Questionnaire-second edition (AAQ-Ⅱ) were used to investigate the caregiving burden, psychological resilience level and acceptance level of caregivers of patients with Alzheimer disease. Pearson correlation analysis was used to explore the relationship between the caring burden of caregivers and psychological resilience and acceptance, and multiple linear regression analysis was used to explore the factors affecting the caregiving burdens of caregivers.Results:A total of 140 questionnaires were sent out and 132 were recovered. The scores of caregiving burden, psychological resilience and acceptance were respectively (48.62±10.22) , (64.32±13.25) and (16.25±5.62) . The scores of various dimensions of caregiving burdens of caregivers of patients with Alzheimer disease were negatively correlated with scores of various dimensions of psychological resilience ( P<0.05) , and positively correlated with the acceptance score ( P<0.05) . The results of multiple linear regression analysis showed that marital relationship, education level, family income, psychological resilience and acceptance were the influencing factors of caregiving burden of caregivers of patients with Alzheimer disease ( P<0.05) . Conclusions:The primary caregivers of patients with Alzheimer disease have a certain degree of caregiving burden, which is negatively correlated with psychological resilience and positively correlated with acceptance. Medical staff should provide professional support to improve the level of psychological resilience and acceptance of caregivers and reduce caregivers' burden.