Objective:To explore the correlations between caregiving burden, psychological resilience and acceptance of caregivers of patients with Alzheimer disease.Methods:Using the convenient sampling method, a total of 140 caregivers of patients with Alzheimer disease who visited outpatient department of Department of Geriatrics and Neurology of Xiangya Hospital of Central South University were selected as research objects from February 2019 to August 2020. Caregivers Burden Inventory (CBI) , Connor-Davidson Resilience Scale (CD-RISC) and Acceptance and Action Questionnaire-second edition (AAQ-Ⅱ) were used to investigate the caregiving burden, psychological resilience level and acceptance level of caregivers of patients with Alzheimer disease. Pearson correlation analysis was used to explore the relationship between the caring burden of caregivers and psychological resilience and acceptance, and multiple linear regression analysis was used to explore the factors affecting the caregiving burdens of caregivers.Results:A total of 140 questionnaires were sent out and 132 were recovered. The scores of caregiving burden, psychological resilience and acceptance were respectively (48.62±10.22) , (64.32±13.25) and (16.25±5.62) . The scores of various dimensions of caregiving burdens of caregivers of patients with Alzheimer disease were negatively correlated with scores of various dimensions of psychological resilience ( P<0.05) , and positively correlated with the acceptance score ( P<0.05) . The results of multiple linear regression analysis showed that marital relationship, education level, family income, psychological resilience and acceptance were the influencing factors of caregiving burden of caregivers of patients with Alzheimer disease ( P<0.05) . Conclusions:The primary caregivers of patients with Alzheimer disease have a certain degree of caregiving burden, which is negatively correlated with psychological resilience and positively correlated with acceptance. Medical staff should provide professional support to improve the level of psychological resilience and acceptance of caregivers and reduce caregivers' burden.