It is a crucial question whether it is necessary to continue the treatment after the patients with chronic myeloid leukemia (CML) who have achieved a complete molecular response (CMR) on imatinib (IM) treatment. If tyrosine kinase inhibitor (TKI) therapy was required indefinitely to maintain CMR, the problems of financial burden and adverse effects would be increased. Approximately 40 ％ of patients with a stable CMR for at least 2 years could stop IM treatment and remain in molecular remission for at least 2 years without IM treatment. Therefore, the ultimate aim should be to give the patients long-term disease control without the need for ongoing treatment. Here the studies progresses of discontinuation of TKI therapy in CML reported in the 53th American Society of Hematology (ASH) annual meeting were reviewed.

Objective To study the effect of comprehensive interventions on anxiety of nursing students at internship. Methods Comprehensive educational interventions were practiced at the beginning,middle-term and end of their internship. The Self-Rating Anxiety Scale(SAS)was adopted to assess their level of anxiety.Results There were differences in SAS scores between the three phases(F=2.680,P<0.05).The scores were decreased from the beginning to the end.Conclusion Targeted comprehensive educational interventions can reduce anxiety and stress of nursing students.

Objective: To explore the effect of three-dimensional reconstruction of abdominal organ CT images based on improved moving cube algorithm. Methods: An adaptive improved marching cube algorithm based on the universal tree structure and the contour points method based on the regional growth method were proposed. Firstly, the medical images were segmented, and all the voxels intersecting with the threshold were marked after the seed points were selected. A general tree structure was created to insert intersecting voxels into sub-nodes and determine the vertex index method based on the general tree. Simplify the acquisition of equivalence information by moving equivalence points to merge coplanar triangles. Based on abdominal CT images of a volunteer, a three-dimensional kidney model was constructed by using traditional moving cube algorithm and improved moving cube algorithm, and the effects were compared. Results: Compared with traditional algorithm, the triangle facets generated with the improved moving cube algorithm were reduced by 39.20%, the efficiency of the algorithm was improved by 37.59%, the surface of the three-dimensional model was smooth and lifelike, and the local details were more accurate. Conclusion: Based on the improved moving cube algorithm, three-dimensional reconstruction of abdominal organs in CT images can be achieved quickly and accurately.

Objective To discuss the effect of the quality control circle(QCC)activities in reducing the incidence of cold in reflux-enema of children.Methods The QCC team was built,reducing the incidence of cold in reflux-enema of children was named as the theme,to grasp the present situation,set the goal,fix the methods and carry out countermeasures.Results Through the development of QCC,making the standards of reflux-enema,the incidence rate of cold reduced from 25.0％(7/28) down to 3.6％(1/28),the nurses' abilities of technical operation and communication improved significantly.Conclusions Application of QCC in reflux-enema of children is practical.It can effectively improve the nurses' awareness of participating in the implementation management and nursing management system.By making the standardization of reflux-enema,nurses can improve the quality and effect of the reflux-enema and ensure the quality and safety of nursing.

Objective To investigate the effects of high concentrations of iodide exposure on mitochondrial superoxide production,cell viability and cell damage in the thyroid of metallothionein Ⅰ/Ⅱ knockout (MT-Ⅰ/Ⅱ KO) mice and corresponding wild type (WT) mice.Methods Thyroid cell suspension of six to eight weeks old healthy male MT-Ⅰ/Ⅱ KO mice and WT mice were prepared.The thyroid cells were treated with high concentrations (10-4,10-3,10-2 mol/L) of potassium iodide(KI),or 10-3 mol/L hydrogen peroxide(H2O2) for 2 hours,respectively.Cell viability was evaluated with methyl thiazolyl tetrazolium(MTT) assay.Lactate dehydrogenase (LDH) level in cell culture medium was detected by enzyme-linked immunosorbent assay(ELISA).Mitochondrial superoxide production in the thyroid cells was measured by flow cytometry using a fluorescent probe,mitochondrial superoxide(MitoSOX).Results Compared to the control group[(100.00 ± 0.00)％,(100.00 ± 0.00)％],the cell viability of 10-4,10-3,10-2 mol/L KI and 10-3 mol/L H2O2 exposure groups were significantly decreased in the thyroid cells of both WT [(73.63 ± 2.05)％,(72.41 ± 2.26)％,(69.63 ± 2.29)％,(44.90 ± 2.93)％] and MT-Ⅰ/Ⅱ KO mice[(65.40 ± 2.39)％,(64.51 ± 2.27)％,(61.48 ± 2.33)％,(40.80 ± 2.76)％,all P＜ 0.05].Compared to the control group [(1 995.28 ± 30.52),(2 004.96 ± 19.71)U/L],significantly increased LDH activities were detected in the thyroid cells of WT [(2 809.22 ± 156.53),(2 850.80 ± 137.83),(2 920.45 ± 152.92),(4 487.49 ± 130.67)U/L] and MT-Ⅰ / Ⅱ KO mice [(3 261.06 ± 120.44),(3 474.19 ± 142.15),(3 597.08 ± 150.86),(4 706.64 ± 148.57)U/L,all P ＜ 0.05].Compared to the control group (26.49 ± 7.66,37.11 ± 8.48),the MitoSOX red fluorescence intensities of 10-2 mol/L KI and 10-3 mol/L H2O2 groups were significantly increased in WT mice(58.96 ± 5.11,87.95 ± 4.25) and MT-Ⅰ/ⅡKO mice(71.21 ± 5.55,99.76 ± 4.42) by flow cytometry (all P ＜ 0.05).Compared to the thyroid cells in WT mice,significantly decreased cell viability (all P ＜ 0.05),significantly increased LDH activity(all P ＜ 0.05) and significantly increased MitoSOX red fluorescence intensity by flow cytometry (all P ＜ 0.05) were detected in the thyroid cells of MT-Ⅰ/Ⅱ KO mice following treatment with KI or H2O2.Conclusions High concentrations of iodide (10-2 mol/L) and 10-3 mol/L H2O2 may lead to significant increase of mitochondrial superoxide production and LDH activity,decrease of cell viability in both WT and MT-Ⅰ / Ⅱ KO mice.More significant increase of superoxide production is detected in MT-Ⅰ / Ⅱ KO mice,indicating the potential protective role of metallothionein in the thyroid cells of WT mice.

Objective To assess the differences in nutrient composition by chemical analysis method and weighing method,A corps of armed police forces daily dietary nutrient intakes were investigated in Tianjin,to understand the status of the actual intakes of dietary nutrient.Methods A dietary survey was performed using the weighing method and with ref-erence to China food composition database in 2002.The intake of each nutrient was calculated through chemical analysis;Nutritional analysis was used in the collection of duplicate food portions during the dietary survey.Results For most of the main dietary nutrients(protein,fat and carbohydrates),minerals (Na,K,Mg,Ca,Zn,Cu and Se)and vitamins (β-car-otene,vitamin E,thiamine,riboflavin,vitamin C,niacin,and vitamin A),the calculated values of intakes were found to exceed those obtained via chemical analysis.Conclusion Differences of the two methods of dietary survey were ultimately due to the analysed values were below the calculated ones.So it is necessary to improve methods of food storage and trans-portation in order to obtain adequate nutrition and to improve the health of troops.

Objective Taking pig kidney as an example, through a series of comparative and analogical experiments, the influencing factors of compressive stress at relaxation stage of biological tissues were analyzed, and a more accurate and widely applicable biomechanical model at relaxation stage was established. Methods The compressive stress relaxation experiments of pig kidney under different conditions were carried out by using the self-built mechanical experiment platform. The collected data were analyzed and mapped, and various factors affecting the relaxation force changes were summarized. Based on the conclusion, the neural network learning algorithm was used to model the force change process at relaxation stage of pig kidney. Results The pre-extrusion pressure and relaxation time were the main influencing factors for compressive stress changes of biological tissues at relaxation stage. The average error of test sample validation experiment was 6.4 mN, and the average prediction error of generalization sample validation experiment was 34.9 mN, so the modeling effect was good. Conclusions Neural network modeling algorithm has the advantages of strong generalization ability and good fault tolerance, which contributes to providing more realistic force tactile feedback prediction for virtual surgery system. It is also a new idea for mechanical modeling of nonlinear biological tissues.

Objective: To investigate the reference level of surface radiation dose of digital radiography (DR) among adult examinees in Beilun District, Ningbo City, so as to provide insights into the optimization of the parameters of DR systems and rational management of the radiation dose. Methods: Based on the cloud imaging system covering 14 DR systems in 11 public hospitals in Beilun District, the diagnosis of adults receiving DR and DR systems check were collected from May 2020 to April 2021. The air kerma-area product ( PKA ) was selected as a measure, and the local diagnostic reference level ( LDRL ), the regional median dose ( RMD ), the regional lowest dose predicted level ( LDPL ) and the typical dose in the DR imaging room were defined using the quartile method according to the examination site, projection direction and radiography positions. The PKA value was transformed into incident air kerma ( Ka, e ), and compared with the recommended value in the Requirements for Radiological Protection in Diagnostic Radiology ( GBZ 130-2020 ). Results: DR was performed among 133 065 person-times from May 2020 through April 2021 in Beilun District. The greatest RMD was found on abdomen AP DR in the supine position ( 120 μGy·m2 ), and the lowest RMD was seen on chest PA DR in the standing position ( 17 μGy·m2 ). The maximums of typical dose in the DR imaging room on chest PA ( 33 vs. 30 μGy·m2 ), abdomen AP ( 161 vs. 153 μGy·m2 ) and pelvis AP DR ( 164 vs. 162 μGy·m2 ) were greater than LDRL in the supine position, and the minimums of typical dose on chest PA ( 10 vs. 11 μGy·m2 ) and chest LAT DR ( 33 vs. 34 μGy·m2 ) were lower than LDPL in the standing position. Following transformation into Ka, e, the LDRL ranged from 0.27 to 3.80 mGy, and the maximums of typical dose ranged from 0.25 to 3.55 mGy, which was much lower than the recommended dose proposed in the national criteria. Conclusions The reference level of surface radiation dose of DR is established among adults in Beilun District, which is lower than the recommended dose in the national criteria of China. Such a reference level may be employed by medical institutions for optimization of the parameters of DR systems. Key words： digital radiography radiation dose diagnostic reference level air kerma-area product

Objective To retrospectively study the influence of Shenmai injection on clinical effects and cellular immune function of patients with severe acute pancreatitis (SAP).Methods A total of 70 patients with SAP in our hospital was retrospectively analyzed,and were randomly divided into observation group (traditional therapy and Shenmai injection) and control group (traditional therapy),with 35 cases per group.The general information,the clinical effects,acute physiology and chronic health evaluation Ⅱ scores (the APACHE Ⅱ scores),the immunity indicators (levels of NK T cells,CD4+ T cells,CD8+ T cells,CD4+/CD8+) before and after treatment,the adverse reaction rates in two groups were compared.Results The general information in two groups had no statistically significant difference (P ＞ 0.05).The disappearance of abdominal pain and distension,the time that returned to normal temperature,the first defection,normal levels of amylase in blood and urine,the length of stay in observation group were obviously shorter than that in the control group (P ＜ 0.05).The APACHE Ⅱ scores in two groups after treatment were obviously lower than treatment before,and the levels of immunity indicators after treatment were obviously higher than treatment before (P ＜ 0.05).After treatment,the APACHE Ⅱ score in observation group was obviously lower,and the immunity indicators in observation group were obviously higher than that in the control group (P ＜ 0.05).The adverse reaction rate in observation group was obviously lower than that in control group (5.9％ vs.27.3％,x2 =5.584,P =0.02).Conclusion Shenmai injection can improve the cellular immune function of SAP patients.

Objective To retrospectively study the influence of Shenmai injection on clinical effects and cellular immune function of patients with severe acute pancreatitis (SAP).Methods A total of 70 patients with SAP in our hospital was retrospectively analyzed,and were randomly divided into observation group (traditional therapy and Shenmai injection) and control group (traditional therapy),with 35 cases per group.The general information,the clinical effects,acute physiology and chronic health evaluation Ⅱ scores (the APACHE Ⅱ scores),the immunity indicators (levels of NK T cells,CD4+ T cells,CD8+ T cells,CD4+/CD8+) before and after treatment,the adverse reaction rates in two groups were compared.Results The general information in two groups had no statistically significant difference (P ＞ 0.05).The disappearance of abdominal pain and distension,the time that returned to normal temperature,the first defection,normal levels of amylase in blood and urine,the length of stay in observation group were obviously shorter than that in the control group (P ＜ 0.05).The APACHE Ⅱ scores in two groups after treatment were obviously lower than treatment before,and the levels of immunity indicators after treatment were obviously higher than treatment before (P ＜ 0.05).After treatment,the APACHE Ⅱ score in observation group was obviously lower,and the immunity indicators in observation group were obviously higher than that in the control group (P ＜ 0.05).The adverse reaction rate in observation group was obviously lower than that in control group (5.9％ vs.27.3％,x2 =5.584,P =0.02).Conclusion Shenmai injection can improve the cellular immune function of SAP patients.