Objective To estimate the intima-media thickness and the wall resilience of common carotid arteries using QIMT and QAS in patients with hypertension,hyperlipidemia,transient ischemic attack and impaired glucose tolerance.Methods The IMT and vessel stiffness parameters including stillness paranleter(β) and compliance coeficient(CC) were obtained in 123 patients with hyperlipidemia,20 patients with hyperlipidemia,21 patients with transient ischemic attack and 36 patients with impaired glucose tolerance,the results were compared with normal control group.Results The IMT [(785.12 ± 114.72) μm,(757.89 ± 86.24) μm,(785.67 ± 143.43) μm,(790.12 ± 163.06) μm] and β in patients [(12.59 ± 0.85),(12.28 ± 1.08),(12.59 ± 0.87),(12.60 ± 1.15)] were higher than those in the control group[(546.30 ± 119.34) μm,(6.80 ±0.90)],CC in patients [(1.01 ± 0.28) mm2/kPa,(0.96 ± 0.24) mm2/kPa,(1.01 ± 0.22) mm2/kPa,(1.02 ± 0.30) mm2/kPa] was lower than that of the control group[(1.29 ± 0.26) mm2/kPa],there was significant difference(all P ＜ 0.01).Conclusion QIMT and QAS technique have advantages of real-time,high degree of accuracy to detect common carotid artery early structural and functional changes,which have certain value for the early diagnosis of AS.