Objective To investigate the effect of long-term walking exercise on the health status of low-labor-intensity population under long-term walking exercise.Methods A total of 100 volunteer teachers from universities in Beijing were enrolled.After physical examination,they were randomly divided into control group and observation group.The observation group regularly carried out corresponding encouragingactivities and recorded the daily number of steps.The corresponding indexes were measured again after 450 days.Results 45.24％ participants in the observation group got more than 75％ participation rate.The lower the participation rate,the lower the average daily steps (P ＜ 0.05).The fasting blood glucose,systolic blood pressure,LDL and total cholesterol were lower than other groups in the group participation rate ＜25％ (P ＜0,05).The body mass index,systolic blood pressure,fasting blood glucose,total cholesterol,ratio diabetes and hypertension in low activities group (＜ 7 500 steps/day) were lower than those in other groups (P ＜ 0.05).Conclusions Walking exercise can achieve good long-term persistence with constant feedback.For those who are older and whose initial indicators are higher,participation rate and exercise volume are more likely to be better under the guidance of encouragement.Persisting long-term walking exercise can help reduce blood pressure and blood lipids.

Objective To investigate the long-term quality of life ( QOL ) in the patients after percutaneous coronary intervention (PCI) and to explore its influencing factors in order to provide the basis for clinical nursing and health education .Methods A total of 1 028 patients with PCI from June 2012 to May 2013 were surveyed by the CROQ-PTCA-Post, and the results were analyzed .Results The average score of long-term QOL in patients with PCI was (69.58 ±7.97), and the scoring rate 69.6%.The scoring rates of different dimensions from high to low were respectively 97.3% ( adverse reactions ), 77.1% ( cognitive function ), 68.5%(treatment satisfaction), 60.3%(physical function), 58.9% (symptoms), 55.5% (psychological and social function ) .The one-way ANOVA showed that the differences were found between the total score of QOL in patients at the different stages after the operation and the scores of four dimensions including symptoms , physical function, psychological and social function , treatment satisfaction (P <0.01).Conclusions The long-term QOL in the patients after PCI is generally lower , and the various types of health education should be pertinently carried out , and the social support system should be fully mobilized , and the postoperative follow-up system should be improved in order to increase the long-term QOL in the patients .

Objective To evaluate the effects of transitional self-management intervention on patients after percutaneous coronary intervention ( PCI ) .Methods One hundred PCI patients were assigned into the control group (50 cases) and the intervention group (50 cases) according to draw method.The control group was treated with the cardiology conventional health education .The intervention group was treated with the self-management model and the transitional nursing model .The coronary artery self-management scale ( CSMS) was used to compare between the groups at one month and six month after PCI .Results There was no significant difference in the score of CSMS before the investigation (P>0.05).After one month of intervention, the score of daily management , disease management and emotional cognition of the intervention group were ( 48 .17 ± 7.20), (46.43 ±5.66) and (47.96 ±9.69), respectively, which were significantly higher than (30.68 ± 8.51), (33.40 ±4.86) and (22.44 ±8.56) in the control group, the difference was statistically significant (t=10.539, 10.767, 13.221, respectively;P <0.01).After six month of intervention, the score of daily management, disease management and emotional cognition of the intervention group were (58.83 ±6.16), (65.30 ±5.28) and (61.55 ±8.23), respectively, which were significantly higher than (30.68 ±8.51), (28.45 ±5.07) and (24.00 ±7.25) in the control group, the difference was statistically significant (t =18.373, 33.822, 22.929, respectively;P <0.01).After one month of intervention, the self-management knowledge and behavior of the intervention group were significantly better than the control group , the difference was statistically significant (P <0.05).At one month, the daily management, disease management and behavior of the control group was significantly improved , the difference was statistically significant (P<0.05).However , the score of disease management at six month after the intervention was significantly decreased compared with that at month, the difference was statistically significant (P<0.05).Conclusions Comparing with the conventional health education , the transitional self-management intervention is effective , and it is worthy of getting widely extension in hospital .

Objective: To investigate adolescent haze weather health protection behavior, and to provide scientific basis for behavioral intervention and health guidance for adolescents in haze weather. Methods: From June 2015 to April 2016, 1 025 adolescents were selected from 22 classes in two middle schools of Baoding City, Hebei Province, by stratified cluster sampling method. General information questionnaire and the Brief Haze Weather Health Protection Behavior Assessment Scale Adolescent Version (BHWHPBAS AV) were used. Multiple linear regressions were conducted to explore factors affecting adolescent haze weather health protection behavior. Different models were used to confirm associations between influencing factors and BHWHPBAS AV scores. Results: Adolescents had a low overall score of BHWHPBASAV (45.81±13.16). The score rate of self adjustment after haze weather was the highest (64.54%). The score rate of obtaining relevant knowledge before haze weather was the lowest (50.28%). Compared with adolescents in urban area, rural adolescents had a lower BHWHPBAS AV score ( β=-3.20, P <0.01). Compared with students (living with parents), those living without parents had a lower BHWHPBAS AV score ( β=-4.16, P =0.01). Compared with students never receive physical examination,those had received physical examination during the past years had a higher BHWHPBAS AV score ( β=4.44，5.66，9.04, P <0.01). Compared with students with no knowledge of respiratory system diseases, those with moderate to sufficient knowledge had a higher BHWHPBAS AV score ( β=9.34，12.19，P <0.01). These associations were stable and consistent.Multiple linear regression analysis showed that residence, residence with parents, physical examination and knowledge of respiratory diseases were the relevant factors of BHWHPBAS AV score ( P <0.05). Conclusion Adolescent haze weather health protection behavior level is low and is affected by many factors. Cooperation should be strengthened to conduct behavioral interventions and health guidance on haze health protection for adolescents, so as to promote healthy growth of adolescents.

Objective:To explore the key targets and mechanism of Bielong Ruangan decoction in the treatment of liver cancer based on network pharmacology and molecular docking.Methods:Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP) database, PubChem database and PharmMapper database were used to search and screen the chemical components and related targets of Bielong Ruangan decoction and the targets of liver cancer diseases. The network diagram of " Bielong Ruangan decoction-traditional Chinese medicine-active ingredient-predicted target-disease" was constructed; Protein-protein interaction (PPI) network were analyzed through String database; gene ontology (GO) enrichment analysis was performed through WebGestalt database; Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis was carried out through KEGG Orthology Based Annotation System (KOBAS) database; Molecular docking of the active components and core target proteins of Bielong Ruangan decoction was carried out by using PyMOL, Auto DockVina and other software.Results:Bielong Ruangan decoction had 67 active components, 154 liver cancer targets and 244 pathways. According to the analysis of network pharmacology, Bielong Ruangan decoction may play an anti-cancer role through key targets such as epidermal growth factor receptor (EGFR), mitogen activated protein kinase 1 (MAPK1), estrogen receptor 1 (ESR1), MAPK8, serine threonine protein kinase 1 (AKT1), MAPK14, cysteine protease 3 (CASP3), cyclin-dependent kinase 2 (CDK2), bone morphogenetic protein 2 (BMP2), aldose reductase (AKR1B1) and other key targets. KEGG enrichment analysis showed that the treatment of liver cancer by Bielong Ruangan decoction involved the regulation of vascular endothelial growth factor (VEGF) signaling pathway, tumor necrosis factor (TNF) signaling pathway, thyroid hormone signaling pathway, T cell receptor signaling pathway and other pathways. The results of molecular docking showed that the binding energy of all compounds to protein was less than -5.6 kcal/mol, indicating that each compound and each protein could bind well.Conclusions:Bielong Ruangan decoction participates in the treatment of liver cancer through " multi-component, multi-target and multi-channel" ways, and plays an anti-cancer role mainly by regulating the proliferation and invasion of tumor cells and tumor inflammatory microenvironment.