1.Integration of Traditional Chinese Medicine and Western Medicine Information Resources Based on Distributed Technology
Na LI ; Lingrui BU ; Guirong LIU
World Science and Technology-Modernization of Traditional Chinese Medicine 2015;(8):1739-1742
In order to solve difficulties in traditional Chinese medicine (TCM) and western medicine integration of information resources, based on the research of distributed technology, this article used Web service technology based on SOA architecture associated TCM and western medicine treatment of the same disease. It finally put forward the integrated model of TCM and western medicine information resources based on distributed technology and in-depth design. It solved the problem of professional TCM or western medicine doctors who cannot use combined TCM and western medicine scheme. It realized the integration, reusability and expansibility of TCM and western medicine information resources. It provided important reference for the development of modern medicine.
2.Comparative study on Wnt, Notch signaling pathway molecules in primary breast cancer and matched lymph nodes metastasis stem cells
Lingrui ZENG ; Yuzhen HAN ; Yinglu MA ; Wenxing LI
Chinese Journal of Clinical and Experimental Pathology 2014;(9):963-966
Purpose To investigate the gene expression and significance ofβ-catenin, Cyclin D1 and Notch1 in primary breast cancer stem cells ( BCSC) and matched lymph node metastasis stem cells. Methods 30 cases of breast invasive ductal carcinoma and matched metastasis lymph nodes were made into single cell suspensions, then BCSC were separated from them by immunomagnetic sor-ting. β-catenin, Cyclin D1 and Notch1 gene expressions of Wnt, Notch signaling pathway were detected by real time PCR. ResultsThe expression of β-catenin in primary BCSC and matched lymph nodes metastasis stem cells had statistically no differences ( P >0.05), while the expression of Cyclin D1 and Notch1 in matched lymph nodes metastasis stem cells were significantly higher than the expression in primary BCSC (P<0.01, respectively). Conclusion Compared with the primary cancer stem cells, Cyclin D1 and Notch1 activation in metastasis cancer stem cells are in higher level, which leades to a higher capability of invasion and metastasis, which may be a new therapeutic target.
3. Progress of artificial intelligence for precision medicine in thyroid cancer
Chinese Journal of Clinical Oncology 2020;47(7):369-374
Thyroid cancer has become more prevalent in recent years. Patients urgently need efficient, personalized services based on an accurate assessment. The combination of artificial intelligence (AI) and traditional medical approaches can potentially improve the accuracy of medical decision-making. This review focuses on the use of AI to evaluate and predict the prognosis of thyroid cancer and aims to provide a foundation for the extraction of key information with AI to guide individualized treatment. First, we briefly introduce the concept and development of AI and the significance of precision medicine in the thyroid cancer. Second, the potential applications of AI in diagnosing thyroid cancer and predicting its prognosis are discussed. Furthermore, we analyze the opportunities and challenges of ultrasonic and pathological diagnostic and prognostic evaluation methods based on traditional pathological parameters and the gene mutation pathway model. Finally, we discuss the future research direction of AI in relation to thyroid cancer. Keywords: thyroid cancer, artificial intelligence, precision medicine, diagnosis, prognosis
4.Analysis on External Function and Application of Medicinal Materials and Decoction Pieces in 2020 Edition of Chinese Pharmacopoeia (Volume 1)
Shuo TIAN ; Ming-san MIAO ; Wei-zheng XIONG ; Wei XIONG ; Ming BAI ; Lei LI
Chinese Journal of Experimental Traditional Medical Formulae 2021;27(8):161-167
Objective:To analyze the research status of the external use of medicinal materials and decoction pieces in the 2020 edition of
5.Mixed venous to arterial CO 2 gap as a marker to identify fluid responsiveness in septic shock patients
Xixi WAN ; Furong LIU ; Ruiting LIU ; Lingrui KONG ; Li WENG ; Bin DU
Chinese Journal of Emergency Medicine 2023;32(4):482-488
Objective:To investigate the value of the venous-to-arterial CO 2 gap (Δ CO 2 gap) before and after the fluid challenge (FC) in determining the fluid responsivenessin septic shock patients. Methods:A total of 104 septic shock patients admitted to the Medical Intensive Care Unit (MICU) of Peking Union Medical College Hospital were included in the retrospective study. All patients were monitored by Swan Ganz floating catheter during the FC. Hemodynamics and blood gas indices were collected before FC (T0) and immediately (T1), 10 min (T2), 30 min (T3) and 60 min (T4) after FC. Responders were defined as patients with a > 10% increase in cardiac output (CO) after FC. Spearman correlation analysis was used to evaluate the correlation between CO 2 gap and CO. The value of ΔCO2 gap were calculated by the area under the receiver operating characteristic (AUROC) curve in the whole population. Results:Among 104 patients, the effective rates of FC at T1, T2, T3 and T4 were 59% (61/104), 72% (75/104), 73% (76/104), and 77% (80/104), respectively. CO of patients in the reactive group was lower than that in the non-reactive group at T2 [6.0 (4.7, 7.5) vs. 7.2 (6.4, 8.5) L/min, P=0.019], and there was no significant difference in CO 2 gap between the two groups before FC. Spearman correlation analysis showed that CO 2 gap was negatively correlated with CO, and the correlations between CO 2 content gap and CO was -0.34, and -0.33 of CO 2 pressure gap and CO, respectively (both P <0.05). ROC curve analysis showed that the ΔCO 2 gap at T1 could weakly judge the reactivity at T2, T3 and T4, but could not judge the reactivity at T1. The AUROC at T2 was 0.669 of ΔCO 2 content gap and 0.684 of ΔCO 2 pressure gap (both P <0.05). Conclusions:The evaluate time judging the effect of FC should be appropriately extended. The change value of CO 2 gap before and immediately after volume expansion in septic shock patients can judge the fluid responsiveness within 10 min after FC.
6.Observation of corneal cell in diabetic patients using in vivo confocal microscopy
Lingrui MENG ; Wenqian CHEN ; Yi GAO ; Zi YE ; Zhaohui LI
International Eye Science 2024;24(5):664-670
In vivo confocal microscopy of the cornea is a non-invasive, rapid, and comprehensive technique for real-time, dynamic observation of all layers of the cornea. Confocal microscopy allows the examination of the morphology and cell density in the different layers of the cornea through direct visualization. With the increasing prevalence of diabetes, ocular complications have become common and have garnered more interest and in-depth research from clinical and scientific communities. This paper provides a comprehensive review of research progress made using in vivo confocal microscopy to observe various layers of cornea tissue in diabetic patients.