OBJECTIVE:To probe into the drug categories causing high incidence of exfoliative dermatitis,and to explore the methods for the prevention and cure of this disease.METHODS:240 exfoliative dermatitis cases publicly reported in domestic journal between 1998 and 2008 were reviewed retrospectively and analyzed statistically.RESULTS:Among the total 240 cases,144 were male vs.96 female,which was chiefly induced via oral and intravenous routes;a total of 19 drugs categories(133 kinds)were involved,dominating the first 3 places were anti-infective drugs,central nervous system drugs and antipodagric drugs.Allopurinol,carbamazepine and phenobarbital were top three drugs among all kinds of drugs inducing exfoliative dermatitis.15 patients(6.25%)died.Exfoliative dermatitis was chiefly treated using stosstherapy in which a large dose of the corticosteroids combined antihistamine drugs and calcium gluconate were used,meanwhile antibiotic drugs was used as an anti-infective therapy to reduce the death secondary to septicemia.CONCLUSION:It is urgent to tighten monitoring on the use of key drugs in clinical practice to avoid and decrease the incidence of exfoliative dermatitis induced by anti-infective drugs.

Objective To investigate the clinical significance of universal newborn hearing screening for deaf‐ness predisposing genes in newborns .Methods A total of 965 newborns at Subei Hospital in Yangzhou were taken blood samples at heel and received for deafness predisposing genes screening .The most common deafness genes were detected by gene sequencing ,including mt12SrRNA c .1555A > G ,c .1494C > T ,GJB2 35delG ,167delT ,176_191del16 ,235delC ,299_300delAT ,SLC26A4 281C> T ,589G>A ,IVS7 -2A>G ,1174A> T ,1226G> A ,1229C> T ,IVS15+5G> A ,1975G>C ,2027T > A ,2162C> T ,2168A> G ,GJB3538C> T ,547G> A .At the same time ,all infants received hearing screening .Otoacoustic emission(OAE) was used as the first step screening ,and OAE combined with auto-auditory brainstem response(AABR) detection were used as the second step screening . Results Fifty -three cases (5 .49% ) had partial gene mutation ,one case of 12SrRNA gene mutation ,33 cases of GJB2 gene mutation ,18 cases of SCL26A4 gene mutation ,one case of GJB3 gene mutation .Of 965 cases ,28 cases failed to pass hearing screening while 18 cases did not pass rescreening .There were 10 cases taking audiological di‐agnosis at the age of three months .Six cases were confirmed with hearing loss .There were 905 cases passed thehearing screening and genetic screening ,11 failed born hearing and gene screening .Conclusion That the newborn gene screening was added into the hearing screening can be helpful to find out the deafness predisposing genes and drug -induced or late-onset hearing loss .