1.A Study of Universal Newborn Hearing Screening Combined with Deafness Predisposing Gene Screening in 965 Newborns
Ying WANG ; Bing GUAN ; Shiming YE ; Li XU ; Lingmei CHANG ; Aimin YU
Journal of Audiology and Speech Pathology 2015;(3):248-251
Objective To investigate the clinical significance of universal newborn hearing screening for deaf‐ness predisposing genes in newborns .Methods A total of 965 newborns at Subei Hospital in Yangzhou were taken blood samples at heel and received for deafness predisposing genes screening .The most common deafness genes were detected by gene sequencing ,including mt12SrRNA c .1555A > G ,c .1494C > T ,GJB2 35delG ,167delT ,176_191del16 ,235delC ,299_300delAT ,SLC26A4 281C> T ,589G>A ,IVS7 -2A>G ,1174A> T ,1226G> A ,1229C> T ,IVS15+5G> A ,1975G>C ,2027T > A ,2162C> T ,2168A> G ,GJB3538C> T ,547G> A .At the same time ,all infants received hearing screening .Otoacoustic emission(OAE) was used as the first step screening ,and OAE combined with auto-auditory brainstem response(AABR) detection were used as the second step screening . Results Fifty -three cases (5 .49% ) had partial gene mutation ,one case of 12SrRNA gene mutation ,33 cases of GJB2 gene mutation ,18 cases of SCL26A4 gene mutation ,one case of GJB3 gene mutation .Of 965 cases ,28 cases failed to pass hearing screening while 18 cases did not pass rescreening .There were 10 cases taking audiological di‐agnosis at the age of three months .Six cases were confirmed with hearing loss .There were 905 cases passed thehearing screening and genetic screening ,11 failed born hearing and gene screening .Conclusion That the newborn gene screening was added into the hearing screening can be helpful to find out the deafness predisposing genes and drug -induced or late-onset hearing loss .
2.The treatment of trigeminal neuralgia by resecting maxillary nerve and infraorbital nerve under the endoscopy at the pterygopalatofossa through approach to the maxillary sinus.
Zhongliang WANG ; Wei MA ; Lingmei CHANG ; Li XU ; Xuemei JIAN ; Junzhong ZHANG ; Funian JU
Journal of Clinical Otorhinolaryngology Head and Neck Surgery 2014;28(2):113-114
OBJECTIVE:
This paper presents a method for treating maxillary neuralgia, the second division of trigeminal nerve.
METHOD:
One hundred and thirty six cases with 136 trigeminal neuralgia were treated from 2004 to 2011. All patients were treated with endoscopic surgery at the pterygopalatofossa through approach to the maxillary sinus for resecting maxillary nerve and infraorbital nerve.
RESULT:
One hundred and eighteen patients were relieved after operation and no recurrence of neuralgia was occurred after 2 to 8 years of follow-up.
CONCLUSION
This method had the advantages of avoiding to operate craniotomy with no complications, which was performed easily with valid efficacy.
Aged
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Denervation
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methods
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Endoscopy
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Female
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Humans
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Male
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Maxillary Nerve
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surgery
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Maxillary Sinus
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innervation
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surgery
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Middle Aged
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Trigeminal Neuralgia
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surgery
3.Thinking of the reform of forensic medical higher education under the current circumstance
Ming ZHONG ; Ji-Feng CAI ; Lingmei LAN ; Yun-Feng CHANG ; Xiang WANG ;
Chinese Journal of Medical Education Research 2003;0(03):-
With the advent of intellectual economy and information,the progression of rule of law,and the reforming of system of forensic science in China,some aspects of the higher education of forensic medicine are faced with unprecedented chance and challenge and have to be improved in order to adapt to training creative talented person of forensic medicine in our society.The aspects to be improved include the system of student enrollment,the pattern of higher educa-tion and training of forensic doctor,the contents of forensic medicine course,the traditional teaching method of forensic medicine,and the graduates'further education and so on.