Objective To investigate the effect of negative capacity on drainage time,subcutaneous fluid accumulation,etc.after modified radical mastectomy.Methods 80 breast cancer patients after modified radical mas-tectomy.Used computer to produce random number,then 80 patients were randomly divided into the two groups.A group were adopted negative capacity of 200mL and B group adopted 400mL.Both groups used disposable negative pressure drainage balls.Results A group patients′subcutaneous fluid accumulation incidence was 27.91%,skin flap necrosis incidence was 2.33%,indwelling time was (25.00 ±2.59)days.B group patients′subcutaneous fluid accumulation incidence was 8.11%,skin flap necrosis incidence was 0,indwelling time was (12.00 ±2.34)days. Drainage time and subcutaneous fluid accumulation incidence were reduced in B group in comparison with A group, and the differences were statistically significant(P<0.01 or P<0.05).Conclusion High negative capacity is recommended in postoperative drainage of modified radical mastectomy,with a minimum of the equivalence of maximum daily drainage volume.If not,drainage in early postoperative duration will not be sufficient enough to insure complete adherence of skin flap,and postponed extubation and subcutaneous fluid accumulation would be expected.

ObjectiveTo clarify the associations between plasma fibrinogen （Fbg） and volumetric bone mineral density （vBMD） as well as osteoporosis measured by quantitative computed tomography （QCT）， and to explore the role of plasma Fbg in early screening and diagnosis of osteoporosis. MethodsPatients with hypertension who were hospitalized in the Department of Endocrinology of Sun Yat-sen Memorial Hospital of Sun Yat-sen University from January 2018 to June 2022 and underwent QCT examinations were included for cross-sectional analysis. The study analyzed the correlation between plasma Fbg and osteoporosis in patients. The diagnostic efficacy of plasma Fbg for osteoporosis was evaluated by the area under the receiver operating characteristic （ROC） curve （AUC）. ResultsTotally 441 subjects were included in the analysis， with an average age of 46.0±14.5 years and a prevalence of osteoporosis of 6.4% （28/441）. As the level of plasma fibrinogen increased， the incidence of osteoporosis significantly increased （P<0.000 1）while the average bone mineral density of L1 and L2 were significantly decreased （P<0.05）. Compared with the first quartile of plasma Fbg（1.99g/L -2.37g/L）， the risk of osteoporosis in the fourth quartile of plasma Fbg （3.67g/L-4.46g/L） increased by 8.85 times after adjusting for related confounding factors. ConclusionThis study found a negative correlation between plasma fibrinogen levels and bone density in patients with hypertension. Plasma fibrinogen levels may serve as a potential screening indicator for osteoporosis， aiding in early diagnosis and therapeutic monitoring. This discovery offers a new perspective for the study of bone metabolic diseases and warrants further investigation.