Objective To investigate the effect of negative capacity on drainage time,subcutaneous fluid accumulation,etc.after modified radical mastectomy.Methods 80 breast cancer patients after modified radical mas-tectomy.Used computer to produce random number,then 80 patients were randomly divided into the two groups.A group were adopted negative capacity of 200mL and B group adopted 400mL.Both groups used disposable negative pressure drainage balls.Results A group patients′subcutaneous fluid accumulation incidence was 27.91%,skin flap necrosis incidence was 2.33%,indwelling time was (25.00 ±2.59)days.B group patients′subcutaneous fluid accumulation incidence was 8.11%,skin flap necrosis incidence was 0,indwelling time was (12.00 ±2.34)days. Drainage time and subcutaneous fluid accumulation incidence were reduced in B group in comparison with A group, and the differences were statistically significant(P<0.01 or P<0.05).Conclusion High negative capacity is recommended in postoperative drainage of modified radical mastectomy,with a minimum of the equivalence of maximum daily drainage volume.If not,drainage in early postoperative duration will not be sufficient enough to insure complete adherence of skin flap,and postponed extubation and subcutaneous fluid accumulation would be expected.

Baby cake'' is a kind of baby food which has been traditionally used in certain parts of China. It consists half of rice powder and half of flour. The lysine is the first limiting amino acid of "baby cake'' and it is also deficient in calcium.In order to improve the nutritional value of "baby cake", we enriched it with 0.25% lysine and 0.122% calcium.72 Wistar derived rats were devided into 3 groups: group A was fed with "baby cake" enriched with 0.25% lysine, group B enriched with 0.25% lysine and 0.122% calcium and group C with original "baby cake" as control.The results revealed: body weight, weight and length and density of bones all were better in enriched groups and the best was in the group enriched with lysine and calcium. All were statistically significant.

Objective To conduct the study and comparative analysis on the performance of foreign hepatitis D virus (HDV) an-tibody test kits .Methods The collected 1 000 serum samples were tested by 3 kinds of different reagent :test reagent ,reference rea-gent and third party reagent .The detection results were processed by the statistical method and the judgement was performed base on the S/Co value .Results The Kappa analysis showed that the Kappa value was 0 .950(P<0 .01) .The specificity was 100% ,the sensitivity was 97 .73% and the area under ROC was 0 .986 .Conclusion The test kit has a relatively high accuracy and high consis-tency compared with the diagnostic reagent kits now widely used in domestic .Increasing the clinical detection rate of HDV can play a helping role on prevention ,early diagnosis and treatment of the disease .

Objective To explore the relationship between body mass index (BMI) and frailty among community aged people. Methods A total of 1571 aged people in two communities in Zhengzhou, Henan, China were recruited by convenience sampling method. They were divided into normal group, overweight group and obesity group according to BMI, and were assessed with Fried Frailty Criteria. Results The rates of overweight and obesity were 38.6%and 10.9%, respectively. There was significant difference in the level of frailty among dif-ferent groups (χ2=86.659, P<0.001). Multivariate Logistic regression analysis showed that overweight and obesity were independent risk fac-tors of pre-frailty (P<0.05), and obesity was the independent risk factor of frailty (P<0.05). Conclusion The prevalence of overweight and obesity was higher in community aged people in Zhengzhou, and normal BMI was important to postpone the process of frailty.

Cell adhesion molecules(CAMs) play important roles in specifying cell-cell interactions during development,regeneration,and modification of synaptic activity.The close homolog of L1(CHL1) ,a recently identified member of the immunoglobulin superfamily of cell adhesion molecules,is localizably expressed in the nervous system.CHL1 interacts with like molecules(homophilic interaction) and non-like molecules(heterophilic interaction) on neighboring cells or the extracellular matrix to regulate axon outgrowth and fasciculation,neuronal migration and survival,synaptic plasticity and regeneration after trauma.

Objective To investigate the effect of Montelukast Combined with Symbicort in severe asthma treatment and intervention. Methods The treatment according to different interventions will be January 2015 to January 2017 in our hospital 80 cases of severe asthma groups:control group with routine nursing intervention for a letter form treatment, the observation group with high quality nursing the intervention of montelukast Symbicort treatment; detailed records of patients in the two groups of experimental data, and the data for comparative analysis, to explore the combination of montelukast and Symbicort in severe asthma treatment and intervention effect. Results The high quality nursing intervention meng montelukast Symbicort (observation group) for the treatment of severe clinical the effect of nursing intervention in patients with asthma is better than conventional Symbicort (control group) clinical efficacy, clinical symptoms improved better than the control group, nursing satisfaction was higher than the control group, the difference was statistically significant (P< 0.05). Conclusion The high quality nursing intervention of patients with severe asthma montelukast Symbicort treatment effect significantly, can effectively improve the clinical symptoms of patients, nursing satisfaction is high, it is widely used in clinical treatment of patients with severe asthma intervention.

This infant cereal chiefly consisted of rice meal, fullfat milk powder, rice germ and dried yeast, and fortified with ferrous lactate and calcium carbonate. This mixture contained 14.1% protein, 8.6% fat, 64.3% carbohydrate, 750mg% calcium, 10mg% iron, 1.0mg% zinc and proper amount of various kinds of vitamins.1. Growth test; 84 weaning SD rats were randomly divided into 6 groups:(A) Infant cereal group;(B) Control I; (C) Control II; (A') Infant cereal group; (B') Control I; (D) Casein group. The latter three groups contained 10% protein which were designed for calculating PER. All these different preparations were fed to 6 groups for 4 weeks. The results showed that the body weight gain, the FE, CE and PER were not significantly different between group A and B but there were significant difference between group A and C. The Hb was increased from 11.76g% ( ) and 11.46g%() to 14.30g% and 14.46g% respectively in group A. The bones developed well and no decalcification occured.2.Nitrogen balance test:(A). Infant cereal group; (B) Control I. The results indicated that the TD, BV and NPU of group A were 98.08%, 85.73% and 84.09% and of group B were 97.81%, 87.51% and 85.59% respectively. Both groups obtained the results of positive nitrogen balance, no significant statistical difference. The contents of hepatic and body nitrogen of two groups were also not significantly different.These data demonstrate that this infant cereal is able to promote the growth of weanling rats, to retain positive body nitrogen and to prevent the occurrence of anemia and rickets.

Objective To evaluate the effects of antiviral therapy in prevention of tumor recurrence after curative resection in patients with hepatitis B virus (HBV) related hepatocarcinoma. Methods The data of 78 HBV related hepatocellular carcinoma patients having underwent hepatocarcinoma curative resection were retrospectively analyzed. The patients were divided into 2 groups according to the treatment method and the serum replication level of HBV DNA: 45 patients received antiviral therapy after hepatocarcinoma curative resection (treatment group), including 28 cases of preoperative HBV DNA high replication level (HBV DNA ≥ 107 copies/L), and 17 cases of preoperative HBV DNA low replication level (HBV DNA < 107 copies/L); 33 cases only received hepatocarcinoma curative resection (control group), including 20 cases of preoperative HBV DNA high replication level, and 13 cases of preoperative HBV DNA low replication level. The median follow-up time was 11 months, and the tumor recurrence was observed. The Kaplan-Meier method was used to calculate the tumor-free survival rate, and Cox regression model was used in multi-factor prognostic analysis. Results In the follow-up period, the tumor recurrence rates in treatment group were 84.4%(38/45), in control group were 93.9%(31/33), and there was no statistical difference (P>0.05). The tumor-free survival rates at 6, 12, 18 and 24 months after operation in patients with HBV high replication level of treatment group were 78.6%, 46.4%, 32.1%and 10.7%, and in patients with HBV low replication level of treatment group were 82.4%, 64.7%, 47.1%and 35.3%;these in patients with HBV high replication level of control group were 50.0%, 15.0%, 5.0%and 0, and in patients with HBV low replication level of control group were 92.3%, 46.2%, 30.8%and 15.4%. The tumor-free survival rates in patients with HBV high replication level of control group were significantly lower than those in patients with HBV low replication level of treatment group and patients with HBV low replication level of control group, and there were statistical differences (P<0.05). There were no statistical difference in the tumor-free survival rates between patients with HBV high replication level of treatment group and patients with HBV high replication level of control group, and between patients with HBV low replication level of treatment group and HBV low replication level of control group (P>0.05). Multivariate analysis result showed that preoperative serum HBV DNA ≥ 107 copies/L, lack of antiviral therapy after operation and tumor low differentiation were independent risk factors for tumor recurrence after operations (OR=1.987, 2.119 and 2.539;P<0.05 or<0.01). Conclusions The serum HBV high replication levels and lack of antiviral therapy after operation are independent factors in influencing tumor recurrence in HBV related hepatocarcinoma patients after operation. It might be better that patients with HBV high replication level should receive an antiviral therapy as early as possible after operation.

Ten years have been spent taking a firm grip on medical administration and high tech in the hospital.The skill of organ transplanting has been upgraded and new medical technonogy developed. The overall rising rate of full recovery and the lowering rate of death of serious and critical patients have shown a higher medical quality.All this attributes largely to the growing attention to medical administra- tion and quality control,tightening infection control,more strict practice of ward visits by three ranks of doctors,more care to serious and critical patients and the trianing of technical personnel.More actions have been taken to answer the call of develoPing the hospital through science and technology with special measures focusing on the basic construction required by the call and technical competitiveness of major departments and on the concentrating attacks on hot problems.

BACKGROUND: Hyperbaric oxygen therapy has been considered as an effective therapy for prevention and cure of cerebral infarction traditionally.However, some scholars suggested that hyperbaric oxygen therapy could also result in cerebral infarction, although the mechanism is unclear.OBJECTIVE: To investigate the cause of cerebral infarction due to hyperbaric oxygen therapy.DESIGN: Case-control trial with patients as subjects.SETTING: Department of Hyperbaric Oxygen, Guangzhou General Hospital of Guangzhou Military Area Command of Chinese PLA.PARTICIPANTS: From December 1996 to March 1998, 192 inpatients receiving hyperbaric oxygen therapy were recruited into the trial from the Department of Hyperbaric Oxygen, Guangzhou General Hospital of Guangzhou Military Area Command of Chinese PLA. There were 127 males and 65 females aged 9-78 years. Patients admitted to the department of hyperbaric oxygen were eligible if they had hypoxia or ischemia induced disease and had no contraindication to hyperbaric oxygen therapy. Patients were recruited into the study regardless of the gender, and all patients and their family gave informed consent before enrollment. Patients were excluded if they did not receive hyperbaric oxygen therapy. According to the Diagnosis and Curing Criteria of Clinical Diseases, 6 patients developed into cerebral infarction during hyperbaric oxygen therapy, 3 males and 3 females, at the age of 51-76 years.METHODS: Patients were exposed to oxygen at 0.2 MPa in hyperbaric chamber used for many persons, and inhaled oxygen with a facemask once a day for 80 minutes with an interval of 10 minutes at the 40th minute. Ten days was considered as one course. Background and risk factors were analyzed in 6patients with cerebral infarction and 186 patients without cerebral infarction.MAIN OUTCOME MEASURES: Analysis of distribution of risk factors among cerebral infarction patients, and risk factor levels in patients without cerebral infarction.RESULTS: Among the 6 patients with cerebral infarction, hyperlipidemia was in all 6 cases, hypertension in 5 cases, primary cerebral infarction or hemorrhage in 5 cases, ≥ 60 years old or hyperviscosity in 4 cases, and diabetes mellitus in 1 case. Risk factor aggregation existed in the patients with over four risk factors. Of the 6 patients with cerebral infarction due to hyperbaric oxygen therapy, 5 cases had 4 risk factors and 1 had 5 risk factors. Of the 186 patients without cerebral infarction, 25 cases had 4 risk factors, and no case had 5 risk factors. The risk factor aggregation was relatively impossible (x2 = 54. 37, P ＜ 0. 05 ).CONCLUSION: Risk factor aggregation was found in all cerebral infarction patients, which is closely associated with the probability of cerebral infarction resulting from hyperbaric oxygen therapy.