1.Meta-analysis of the prognosis of cervical cancer after neoadjuvant chemotherapy
Yudai SU ; Lingjun TIAN ; Suhui WU
Journal of Chinese Physician 2016;18(3):388-393
Objective To investigate the effect of neoadjuvant chemotherapy on the prognosis of patients with cervical cancer.Methods A systematic review of the literature about neoadjuvant chemotherapy and radical surgery was performed with searching Pubmed,Cochrane library,Medline,and Embase database from January 1990 to January 2015.According to the inclusion and exclusion criteria,the data were extracted and analyzed by Revman 5.3 system software Meta.Results Ten controlled clinical studies were concluded,including 1 543 patients (667 in preoperative neoadjuvant chemotherapy group and 876 in radical surgery).The extracted data were comparable.Meta-analysis results displayed that significant difference existed in five-year disease-free survival,node-positive rate,vascular invasion rate,and parametrial infiltration rate.It seemed that the preoperative neoadjuvant chemotherapy was prior to the radical surgery in those items.There was no significant difference between the preoperative neoadjuvant chemotherapy and radical surgery in five year survival,intraoperative complication,the positive surgical margin rate,and five-year survival rates among different chemotherapy peers (P > 0.05).Conclusions For locally advanced cervical cancer patients,neoadjuvant chemotherapy can reduce the incidence of high-risk pathology,but had no significant effect on the long-term survival of patients.
2.Alcohol exposure during pregnancy causes non-compaction cardiomyopathy in offspring mice
Huiming ZHOU ; Kunfeng JIANG ; Tiewei LYU ; Lingjun LIU ; Jie TIAN
Journal of Third Military Medical University 2017;39(17):1696-1701
Objective To investigate the relationship of alcohol exposure during pregnancy and non-compaction cardiomyopathy (NCC) in offspring mice.Methods Pregnant mice of ED3.5-ED18.5 were given 56% alcohol by gavage at a dose of 5 mL/kg.The ED19.5 mice were sacrificed,and the heart of the fetal mice was harvested.Transmission electron microscopy (filaments,mitochondria and sarcoplasmic reticulum) and HE staining were used to verify the changes of structure and ultrastructure of the obtained myocardial tissues.Echocardiography was used to evaluate the cardiac function and ventricular myometrium of the offspring mice after growing up.Results Alcohol exposure during pregnancy caused the disorganized and dissolved myofilaments in the fetal mice.Some offspring mice (31.25%,5/16) had NCC.The ratio of non-compacted myocardium to compact myocardium at the end of systole (N/C) was 2.49 ± 0.6 in the offspring mice of the alcohol exposure group,significantly higher than that in the control offspring mice (0.62 ± 0.23,t =10.397,P =0.000).The volume of heart was decreased in the offspring mice of the alcohol exposure group while the left ventricule was enlarged.Echocardiography showed cardiac dysfunction and thickened ventricular septal/left ventricular posterior walls in the grown-up mice of the exposure group.Conclusion Large dose of alcohol exposure during pregnancy cause trabeculations and non-compaction in ventricular myocardium,and it might be one of causers for NCC in the offspring.
3.Potential medical applications of nanoscale particles of viruses.
Kai LI ; Jinling ZHANG ; Qian WANG ; Jun SUN ; Guoning TIAN ; Yan GAO ; Lingjun FANG
Journal of Biomedical Engineering 2014;31(3):718-722
The study of viruses traditionally focused on their roles as infectious agents and as tools for understanding cell biology. Recently, however, with the development of structural biology, viruses have now been receiving particular attention in nanotechnology. By chemical methods or by gene modification, viruses have been functionalized as potential building blocks for several applications, such as drug/gene delivery vehicles, advanced vaccine vehicles, and special inorganic or organic nanomaterials. Here we highlight some of the recent progresses in the medical applications of viruses.
Biomedical Research
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trends
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Gene Transfer Techniques
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Genetic Therapy
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Nanostructures
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Nanotechnology
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trends
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Vaccines
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Viruses
4.Advances in the research of HPV and cervical cancer and precancerous lesions
Lingjun TIAN ; Suhui WU ; Xue LI ; Yimin GAO
Journal of Chinese Physician 2017;19(9):1437-1440
High-risk Human papilloma virus (HR-HPV) has been identified as a necessary factor for the development of precancerous lesions and invasive carcinoma of the genital tract,among which cervical cancer is the most common cancer in the female genital tract.The molecular biological mechanism of HPV leading to malignant transformation of cervix and the epidemiological information of HPV provide us with many strategies for early detection and early intervention of cervical lesions.In recent years,the incidence and mortality of cervical cancer in our country had the trend of increasing.This article reviews the research progress of HPV and cervical cancer and precancerous lesion.
5.The predictive effect of TyG index on type 2 diabetes mellitus
Lingjun RONG ; Zaigang YANG ; Chunlin LI ; Yanping GONG ; Hui TIAN ; Banruo SUN
Chinese Journal of Endocrinology and Metabolism 2023;39(11):917-922
Objective:To investigate the predictive effects of triglyceride-glucose index(TyG) 0 h, TyG 1 h, and TyG 2 h on type 2 diabetes mellitus(T2DM) in elderly male participants without diabetes.Methods:A total of 862 subjects were selected and followed up for 20 years, retrospectively. At baseline, all subjects underwent 75 g oral glucose tolerance test(OGTT) and venous plasma glucose measurements were taken before OGTT(FPG), 1 h and 2 h after OGTT(1 h-PG and 2 h-PG, respectively). Fasting blood lipids and other important biochemical indicators were also detected. The index of fasting serum triglycerides(TG) and FPG, 1 h-PG, 2 h-PG were TyG 0 h, TyG 1 h, TyG 2 h, respectively. Cox proportional hazards regression model and receiver operating characteristic(ROC) curve were used to evaluate the predictive effect of TyG 0 h, TyG 1 h, and TyG 2 h on T2DM.Results:The results of Cox regression model indicated that TyG 0 h, TyG 1 h and TyG 2 h had predictive effects on T2DM at 10 and 20 years of follow-up [At 10 years of follow-up, TyG 0 h: HR=1.538(95% CI 1.267-1.868), P<0.001; TyG 1 h: HR=2.224(95% CI 1.852-2.672), P<0.001; TyG 2 h: HR=2.117(95% CI 1.777-2.522), P<0.001; and after follow-up for 20 years, TyG 0 h: HR=1.431(95% CI 1.204-1.700), P<0.001; TyG 1 h: HR=2.008(95% CI 1.705-2.364), P<0.001; TyG 2 h: HR=1.850(95% CI 1.582-2.163), P<0.001]. After 10 years of follow-up, the area under the curve(AUC) of TyG 0 h, TyG 1 h, and TyG 2 h for predicting T2DM was 0.699, 0.747, and 0.739, respectively. Comparison of AUC, TyG 1 h or TyG 2 h>TyG 0 h. After 20 years of follow-up, AUC of TyG 0 h, TyG 1 h, and TyG 2 h for predicting T2DM was 0.671, 0.723, and 0.705, respectively. Comparison of AUC, TyG 1 h>TyG 2 h>TyG 0 h. Conclusion:The predictive role of TyG 1 h and TyG 2 h in T2DM is superior to TyG 0 h, and TyG 1 h′s long-term predictive effect on T2DM is better than TyG 2 h, which can be used as a reference index to evaluate the risk of T2DM in clinical practice.