Objective To explore the effects of comprehensive nursing combined with acupoint massage on patients with post-stroke depression. Methods Totally 76 patients with post-stroke depression from May 2015 to March 2016 hospitalized in the rehabilitation department of Daqing Longnan Hospital, were divided into the observation group and the control group according to random number table, with 38 cases in each group. Patients in the observation group received comprehensive nursing and acupoint massage, while patients in the control group received routine psychological nursing, and the course of treatment were all four weeks. Hamilton depression scale ( HAMD ) and national institute of health stroke scale ( NIHSS ) in America were used to evaluate the improvement of depression and improvement of neuronal functional recovery. Results Four weeks after treatment, the HAMD score (4.88±1.63) and NIHSS score (6.28± 2. 76) in the observation group were lower than the HAMD score (15.58±3.94) and NIHSS score (17.98± 4.37)in the control group (P<0.05). The total efficiency of improvement in depression (84.2%) and total efficiency of neurological improvement ( 89. 4%) in the observation group, were higher than that in the control group ( P<0. 05 ) . Conclusions Comprehensive nursing combined with acupoint massage has a better curative effect in patients with post-stroke depression than the routine psychological nursing.