Objective To investigate the clinical effectiveness of treatment combining Jiaweichaiqinchengqi decoction and acupoint application in patients with acute pancreatitis(AP). Methods 40 patients with AP received and cured in our hospital from May 2015 to May 2017 were randomly selected and divided into two groups according to different treatments. Observation group consisted of patients with basic treatment of western medicine plus coming Jiaweichaiqinchengqi decoction and acupoint application (n=20). Control group consisted of patients with only basic treatment of western medicine (n=20). Patients in both of two groups received the basic treatment of western medicine of AP. Patients in observation group received the additional treatment combining Jiaweichaiqinchengqi decoction and acupoint application. The clinical effects in two groups were compared. Results The times of blood amylase recovery, gastrointestinal decompression and hospitalization in observation group were significantly shorter than those in control group (P＜0. 05). The total rate of treatment effectiveness in observation group 95. 0％ (19/20) was significantly higher than that in control group 85. 0％ (17/20) (P＜0. 05). The differences of incidence of complications and transferring to ICU in observation and control group were not significant(P＞0. 05). Conclusion Combining Jiaweichaiqinchengqi decoction and acupoint application could reduce the times of blood amylase recovery, gastrointestinal decompression and hospitalization in patients with AP so as to improve the clinical effectiveness. It was worth promotion.