Objective To compare the application value of Azurion comprehensive large plate imaging system based on 3D road map technology and conventional road map in interventional treatment of intracranial aneurysms.Methods A total of 73 patients with intracranial aneurysms,who received treatment at the Department of Neurosurgery of Ganzhou Municipal Hospital of China from February 2021 to May 2023,were enrolled in this study.The patients were divided into study group(n=73,under the guidance of 3D real-time road map)and control group(n=75,under the guidance of conventional road map).The surgery-related indicators,embolization density,image quality,serological indicators,and quality of life were compared between the two groups.The patients were followed up for 6 months.The recurrence rate and prognosis were compared between the two groups.Results Compared with the control group,in the study group the accurate location rate of microcatheter with single catheterization manipulation was higher(P＜0.05),the incidence of intraoperative rupture bleeding was lower(P＜0.05),the time spent for operation was shorter(P＜0.05),and the amount of the contrast agent used and the machine radiation dose were lower(P＜0.05).The Raymond grade distribution in the study group was better than that in the control group(P＜0.05).The excellent rate of image quality in the study group was higher than that in the control group(P＜0.05).The differences of matrix metalloproteinase 9(MMP-9)and neuron-specific enolase(NSE)before and after treatment in the study group were higher than those in the control group(both P＜0.05).The differences of material well-being life,social function,mental health and physical health scores before and after treatment in the study group were higher than those in the control group(all P＜0.05).The postoperative recurrence rate in the study group was lower than that in the control group(P＜0.05).No statistically significant difference in Glasgow prognostic Scale(GOS)score existed between the two groups(P＞0.05).Conclusion Compared with the conventional road map,the use of Azurion comprehensive large plate imaging system based on 3D road map technology has a definite and excellent effect in the interventional treatment of intracranial aneurysms,which can shorten the operation time,reduce the used dose of contrast agent,decrease the risk of intraoperative rupture with bleeding and postoperative recurrence,regulate the expression of serum NSE and MMP-9,improve the quality of life of patients,and ensure a satisfactory prognosis.