Objective To explore the intervention method of PAV to improve the treatment quality of neonatal respiratory failure ( NRF) . Methods A total of 86 preemy with NFR treated with PAV, and randomly divided the into control group ( 44 cases ) and observation group ( 42 cases ) . The infants of control group received the routine nursing care, and the patients of observation group were given comprehensive nursing intervention. Results The average mechanical ventilation time, the average oxygen inhalation time and the average hospitalization time in observation group were shorter than those of control group, and the differences were statistically different ( P < 0. 05 ); the incidence of complication during the application of PAV in observation group was 9. 52%, and 25. 00% in control group (χ2 =4. 925,P <0. 05). Conclusions The standardized PAV nursing intervention can decease the incidence rate of NRF, shorten mechanical ventilation time and improve the treatment quality of NRF.