Objective To analyze the proprietary Chinese medicine adverse reaction(ADR),thus to promote rational drug use in clinical.Methods According to clinical physicians,nurses and pharmacists fill in drug ADR reports,collected 48 cases of proprietary Chinese medicine ADR reports in our hospital during 2012-2015.The patients'age,sex,adverse reactions and drug varieties and aspects and so on,involved organs or systems,the prognosis were analyzed.Results According to the age distribution,children under the age of 10 years had 24 cases (50.00％).According to the varieties of drug,Reduning injection caused adverse reaction was up to 25 cases (52.08％).Damage to one of the most common clinical manifestations in the skin and accessories,a total of 29 cases (60.42％).Conclusion We should pay attention to the ADR of Chinese medicines,strengthen the monitoring analysis of daily work,avoid or reduce ADR,the clinical use of Chinese patent medicine is more safe and reasonable.