Objective To study the effect of circumferential fibrotomy assisted periodontitis orthodontic depression on the prognosis of periodontitis .Methods 70 patients with crescent periodontitis were selected as study objects,and they were randomly divided into two groups according to the digital table ,35 cases in each group.The conventional group did not received circumferential fibrotomy auxiliary the treatment , and was only given periodontal treatment.The circumferential fibrotomy group received circumferential fibrotomy assisted periodontitis with orthodontic treatment.Patients with half a year relapse rate,the masticatory efficiency,tumor necrosis factor alpha (TNF-α), interleukin-1 beta (IL-1β),the crown root ratio,alveolar bone absorption ratio,the bone and tooth alveolar crest distance between the two groups were compared .Results The half a year relapse rate in the circumferential fibrotomy group was lower than that of the conventional group (5.71％vs.22.86％,χ2 =4.200,P<0.05).Before treatment, the crown root ratio,alveolar bone absorption ratio ,bone and alveolar crest distance between the two groups had no statistically significant differences (t=0.422,0.771,0.914,1.031,all P>0.05).After treatment,the crown root ratio,alveolar bone absorption ratio ,alveolar bone and alveolar crest in the circumferential fibrotomy group decreased more significantly,the differences were statistically significant compared with the control group (t=6.255,6.024, 7.025,7.355,all P<0.05).Before treatment,the masticatory efficiency,TNF-α,IL-1βbetween the two groups had no statistically significant differences (t=0.155,0.544,0.343,all P>0.05).After treatment,the masticatory efficiency of the circumferential fibrotomy group was higher than that of the control group ,the TNF-α,IL-1βlevels were lower than those of the control group (t =6.266,4.924,5.025,all P<0.05).Conclusion Circumferential fibrotomy assisted periodontitis orthodontic depression has effect on the prognosis of periodontitis ,which can effectively improve the periodontal health ,reduce the release of inflammatory factors ,promote the recovery of alveolar bone height and improve the masticatory function.

Endo-β-N-acetylglucosaminidase is used widely in the glycobiology studies and industries. In this study, a new endo-β-N-acetylglucosaminidase, designated as Endo SA, was cloned from Streptomyces alfalfae ACCC 40021 and expressed in Escherichia coli BL21 (DE3). The purified recombinant Endo SA exhibited the maximum activity at 35 ºC and pH 6.0, good thermo/pH stability and high specific activity (1.0×10⁶ U/mg). It displayed deglycosylation activity towards different protein substrates. These good properties make EndoSA a potential tool enzyme and industrial biocatalyst.
Cloning, Molecular ; Enzyme Stability ; Escherichia coli ; genetics ; Gene Expression ; Mannosyl-Glycoprotein Endo-beta-N-Acetylglucosaminidase ; genetics ; metabolism ; Recombinant Proteins ; genetics ; metabolism ; Streptomyces ; enzymology ; genetics