Objective To explore the effects of applying standards of diagnosis-related group ( DRG) nursing quality to patients with parotid pleomorphic adenoma .Methods Sixty-four patients in our department with parotid pleomorphic adenoma were randomly divided into control group ( n=32 ) and experimental group ( n=32 ) . The control group received traditional nursing care , while the experimental group received departmental standards of DRG ( parotid pleomorphic adenoma ) nursing.The nursing quality and effects were compared, as well as the satisfaction of patients .Results The related knowledge understanding rates in the experimental group and control group were 93.75% and 71.88%, respectively, which showed a significant difference (χ2 =7.540,P<0.05).And patients’ satisfaction rates in the experimental group and control group were 90.63% and 81.25%, respectively, which showed a significant difference (χ2 =13.506,P<0.05). There were significant differences in the mean of hospitalization days and hospitalization expenses (t=730.00, 883.50,respectively;P<0.05).Conclusions The new quality standards and template of DRG in patients with parotid pleomorphic adenoma can make nursing work more standardized , and can improve nursing quality effectively.The hospitalization days and expenses can be significantly reduced and the understanding of health education and patients ’ satisfaction can be improved .