Now China vigorously promoted the reform of the disease prevention and control system and the construction of the public health system. In the context of the reform of the disease prevention and control system, grassroots disease prevention and control institutions have been greatly improved in terms of the number and structure of personnel, the configuration of facilities and equipment, the construction of information technology, and the ability of laboratory testing. However, it is still a challenge for grassroots disease prevention and control institutions to achieve long-term development under the supportive development policy of ^“one type of protection and two types of management^”. Paper in Wuhan district of institution of disease prevention and control, for example, by analyzing its current working train of thought, puts forward the basic institution of disease prevention and control should be in the internal management level, social level and system level under the three-dimensional development ideas, fully show the technical characteristics, improve the ability of the business, to provide more diversified public health services to the public, may be able to get long-term, stable and continued development.