Objective To study parecoxib sodium preemptive analgesia on agitation and inflammatory factors in patients with esophageal cancer.Methods 78 patients with esophageal cancer were randomly divided into two groups,the control group(n =39 cases) and the observation group(n =39 cases).The patients in observation group received parecoxib sodium preemptive analgesia,while the patients in the control group were given NS.Then,both two groups were given conventional anesthesia.Restlessness was observed in patients with grading and Remesay sedation score.Serum concentrations of interleukin-6 (IL-6) and interleukin-10 (IL-10) were measured before anesthesia (T0),surgery (T1),6h after operation (T2),and 24h after operation (T3).Results Degree of agitation in the observation group was significandy lower than the control group (x2 =6.26,P ＜ 0.05).In the control group,irritability,sedation,sedation were 18 cases,20 cases,one case and those in the observation group were 6 cases,32 cases,one case.Higher satisfaction with sedation in the observation group(x2 =7.26,P ＜ 0.05),irritability rate in the observation group was lower than the control group (x2 =10.14,P ＜0.05).In the postoperative T1,T2,T3 moment,serum IL-6 level in the observation group was lower than the control group(t =3.172,4.001,2.702,all P ＜0.05),serum IL-10 level was higher in the observation group(t =3.112,2.624,3.092,all P ＜ 0.05).Conclusion Parecoxib sodium preemptive analgesia can decrease agitation and balance inflammatory factors in patients with esophageal cancer.

Objective To investigation and analysis the related factors of delayed treatmen (pre-hospital and in-hospital) in pa-tients with acute myocardial infarction (AMI) .Methods 218 patients with AMI from inpatient department of cardiology and emer-gency ,and to analyze the factors that may affect patients medical timely through investigated and analyzed more than 20 specific fac-tors ,including general information ,human and social factors ,etc .Results In 218 case of AMI ,47 cases of timely treatment (21 .6% ) ,171 cases of delaying treatment (78 .4% ) in 218 patients with AMI .The results showed that education level ,disease awareness level ,economic income ,previous history of heart disease ,chest pain level ,treatment distance ,transport choices and whether call a first-aid or not had significant differences between timely treatment group and delaying treatment group (P<0 .05) . Hospital diagnosis and treatment delay may link with waiting time ,waiting for examination ,the doctor′s advice-delivery time .Con-clusion Patients with AMI treatment delay is serious ,the awareness of patients timely treatment and hospital management system should be further improved .

AMP-activated protein kinase (AMPK) is an important regulator of cellular energy homeostasis. Recent studies demonstrated that AMPK is a novel signaling molecule modulating inflammatory responses and oxidative stress which are involved in inflammatory pulmonary diseases, such as asthma, chronic obstructive pulmonary disease (COPD), pulmonary infectious diseases and pulmonary fibrosis. AMPK attenuates inflammatory lung injury by phosphorylating its downstream targets, such as sirtuin1 (SIRT1), peroxisome proliferator-activated receptor gamma coactivator-1alpha (PGC-1alpha), p53 and forkhead box O3a (FoxO3a). This review summarized the relationship between AMPK and the development of inflammatory pulmonary diseases.
AMP-Activated Protein Kinases ; metabolism ; Forkhead Box Protein O3 ; Forkhead Transcription Factors ; metabolism ; Homeostasis ; Humans ; Inflammation ; enzymology ; Lung Diseases ; enzymology ; Oxidative Stress ; PPAR gamma ; metabolism ; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha ; Phosphorylation ; Sirtuin 1 ; metabolism ; Transcription Factors ; metabolism ; Tumor Suppressor Protein p53 ; metabolism

Corneal collagen cross-linking (CXL) is a photochemotherapy for keratoconus, keratectasias and infectious keratitis.Corneal collagen fiber infiltrated with riboflavin, a photosensitizer which generates reactive oxygen species when activated by UVA at 370nm, was induced to form the crosslinks in corneal stroma.Corneal collagen cross-linking alone or combined with medicine therapy could be used to treat fungal keratitis, improve the cure rates, and reduce the complications and the demands of corneal transplantation surgery.The purpose of this paper is to review the basic principle, procedure, laboratory researches, clinical applications and the safety about this treatment.

Objective:To observe the effect of nape acupuncture on vertebral-artery type cervical spondylosis.Methods:Eighty patients with vertebral-artery type cervical spondylosis were randomly divided into nape acupuncture group and Jiaji acupuncture group,with 40 cases in each group.The patients in the nape acupuncture group were treated with the nape acupuncture plus Jiaji acupuncture,while the patients in the Jiaji group were treated with Jiaji acupuncture only,to observe the functional scale before and after treatment.Results:The total effective rate in the nape acupuncture group was 95.0%,while the total effective rate in the Jiaji acupuncture group was 82.5%.By Ridit analysis,u=5.186,P＜0.01.It indicated that the therapeutic effect in the nape acupuncture group was better than that in the Jiaji acupuncture group.Compared with Jiaji acupuncture group,the difference value of pre- and post-treatment about functional scale of vertebral-artery type cervical spondylosis and the post-treatment score have statistic differences (P＜0.01).It indicated that the therapeutic effect of nape acupuncture group was more obvious in treating vertigo than that in the Jiaji acupuncture group.Conclusion:The treatment of vertebral-artery type cervical spondylosis by Jiaji acupuncture plus the nape acupuncture may enhance the therapeutic effect significantly.

Objective To analyze the risk factors and clinical characteristic of placental abruption. Methods We retrospectively analyzed the medical documents of 45 patients treated in the first affiliated hospital of Kunming medical university during 2010 to 2012. All mild placental abruption patients and severe placental abruption patients were used to analyze the high risk factors and outcomes of pregnancy. Results The incidence of placental abruption was 0.41%. Seventeen severe placental abruption patients and 28 mild placental abruption cases were included in this study. The incidence of uteroplacental apoplexy and perinatal infant outcomes were significant diferenct between two groups (P≤0.023) .The high risk factors were hypertensive disorders in pregnancy, premature rupture of membranes,complicated with other diseases in pregnancy, and so on. About 22.2%placental abruption couldn't be explained by any reasons. Conclusions Severe placental abruption can occur in pregnant women with no high risk factors and cause bad pregnant outcomes. To improve the skills of medical personnel is the powerful measure in placental abruption treatment.

OBJECTIVE: To explore the mechanism of Schisandra lignans for inducing the apoptosis of human glioma SHG-44 neurospheres. METHODS: The effects of Schisandra lignans on the SHG-44 neurospheres proliferation were detected by MTT. The apoptotic rate was analyzed by Annexin-V/PI double staining. The secretion of the bax, bcl-2 and caspase 3 protein was detected by Elisa assay. The expression of bcl-2 protein was examined by Western blot. RESULTS: Schisandra lignans could inhibit the proliferation of SHG-44 neurospheres with the concentration of 50,100,200 mg · L-1 in a dose-dependent manner. Schisandra lignans could induce the apoptosis of SHG-44 neurospheres in a dose-dependent manner. The secretion of bcl-2 was decreased, but ratio of bax/bcl-2 was increased, caspase 3 was increased, the expression of bcl-2 protein was down-regulated. CONCLUSION: Schisandra lignans could induce the apoptosis of human glioma SHG-44 neurospheres. Its mechanism is correlated with down-regulation of the expression of bcl-2 and up-regulation of the ratio of bax/bcl-2, and then activated caspase 3.

0.05) in vitamin D_3 plus nicotine (VDN) group. The values of +LV dp/dt_ max and-LV dp/dt_ max were significantly lower in VDN group (P

Objective To analyze the clinical manifestations of placental abruption ,and try to provide evidence‐based data for early diagnosis .Methods Retrospective cases of placental abruption from January 2008 to March 2014 were analyzed ,the clinical characteristics ,etiological factor and outcomes were compared .Results There were 58 cases in Ⅰ degree ,45 cases in Ⅱ degree and 21 cases in Ⅲ degree .The incidence of PIH in Ⅰ degree group was significantly lower than that in Ⅱ degree group ,the incidence of PROM in Ⅰ degree group was significantly higher than that in Ⅱ and Ⅲ degree groups(P< 0 .05) .The main symptoms of Ⅰ degree group were vaginal bleeding .The main performances of Ⅱ and Ⅲ degree group were abdominal pain with or without vaginal bleed‐ing .The cesarean section rate of Ⅰ degree group was significantly lower than that of Ⅲ degree group ,and the rate of maternal‐fetal adverse outcomes was statistically lower than Ⅱ and Ⅲ degree groups (P< 0 .05) .Conclusion It is helpful for early diagnosis of placental abruption and improving prognosis by regular prenatal care ,analyzing and combining with history or risk factors ,ultra‐sound ,physical examination ,and paying attention to clinical performance like abdominal pain and vaginal bleeding ,as well as impro‐ving the ability to identify the abnormal FHR .

Acupuncture Points ; Acupuncture Therapy ; Female ; Humans ; Meige Syndrome ; therapy ; Middle Aged