Objective To know the effects of comfort nursing cares on strok patients'limb function rehabilitation. Methods Divided 100 patients with cerebral apoplexy into the experimental group and the control group randomly,there were 50 cases in each group. Routine nursing cares was used in the control group,while the comfort nursing cares was used in the experimental group in addition. Evalued the ability of daily living,move function and the incidence rate of complications between the two groups by Barthe and Fugl-Meyer after 3-month intervention. Results Before the intervention,there was no significant difference between the two groups about values of Barthe and Fugl-Meyer,while after the intervention,the difference was significant. The incidence rate of complication in the control group was significant higher than that in the experimental group. Conclusions Comfort nursing cares can effective promote the rehabilitation of limb function in strok patients with few complications.

Objective To investigate the rehabilitation training and education of one pair of twins with severe spasm type cerebral palsy(CP).Methods The rehabilitation training and education lasting 6 years was performed for one pair of twins(two girls with dysfunction in motion,one had basically normal intelligence,another one had poor intelligence).Results After rehabilitation training and education,the child with normal intelligence could walk by the help of crutch(initially,she could not sit independently)and study in a common learning environment with other child and gain a good performance record.Another child with low intelligence had very little improvement in motor function and intelligence.Conclusion By rehabilitation training and education,the children with cerebral palsy can minimize their disabled level on intelligence and recover their motor function.

目的探讨脑瘫儿童康复治疗和教育的基本方法及其关系。方法将60例脑瘫患儿分为康复组、教育组和康复+教育组各20例,观察康复训练和教育效果。结果2年后,WeeFIM量表评定康复组和教育组为有效,而康复+教育组为基本恢复,且疗效优于康复组和教育组(P<0.05)。结论对脑瘫患儿分阶段、有针对性地采取医疗康复与教育相结合的方法,可获得良好效果。

Objective The aim of this study was to assess the effect of hemodialysis combined with hemoperfusion for the treatment of microinflammation in diabetic nephropathy patients.Methods One hundred and twenty-five cases of diabetic nephropathy experienced treatment from July 2014 to December 2015 in author's hospital were analyzed retrospectively.They were divided into two groups randomly.The observation group received hemodialysis combined with hemoperfusion,and the control group received just hemodialysis therapy.The status of microinflammation and curative effect were compared.Results The effective rate of observation group was 60.6％,while was 45.8％ in control group (P＜0.05).Microinflammation level:compared with control group,SAA,IL-6,IL-17,IL-22,IL-1β,TNF-αand TGF-β1 status of observation group showed decreased trend (P＜0.01).Conclusion Hemodialysis combined with hemoperfusion can effectively decreased microinflammation status in diabetic nephropathy.

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Objective To investigate the impact of methylene tetrahydrofolate reductase (MTHFR) gene polymorphism on folicacid for lowering plasma level of homocysteine in elderly patients with coronary heart disease (CHD). Methods In the first affiliated hospital of Zhengzhou university,a total of 180 elderly patients with CHD were randomized to two groups. The study group (91 ptients) received folicacid 5mg once daily and the control group (89 patients) received no folic acid. 8 weeks after treatment, the changes in plasma Hcy were observed and analyzed by MTHFR genotypes (TT vs. CC vs. CT). Results Plasma Hcy of the three genotypes had a statistical significance at the baseline (P<0.001), among which plasma Hcy level was the hightest in patients with genotype TT, while it had on difference in genotypes CC and CT (P = 0.057). 8 weeks after treatment, plasma Hcy level declined up to 24%in the patients with genotype TT in the study group, while it decreased about 6%and 15%in patients with genotype CC or CT, separately. Hcy level was slightly decreased in the patients with genotype CC, CT, or TT in the control group. Conclusions Plasma Hcy level differs statistically in three genotypes, and it is the highest in genotyp TT. Folicacid can effectively lower the level of plasma Hcy in elderly patients with CHD, especially those with genotype TT.

Objective To evaluate the therapeutic effects of microwave coagulation and balloon dilatation on benign esophageal stenosis. Methods The location and degree of esophageal stenosis was diagnosed by endoscopy. Balloon dilatation or microwave coagulation plus balloon dilatation were selected to treat esophageal stenosis according to the severity of esophageal stenosis. Results 87 cases of esophageal stenosis were caused by esophageal anastomosis after esophagectomy (n=37), radiotherapy(n=25), chemical damage(n=22) and unclear causes(n=3) respectively. 66 cases of esophagostenosis were treated by balloon dilatation and 21 cases were treated by microwave coagulation plus balloon dilatation. 78 cases of esophageal stenosis were significantly improved, 8 cases were improved, and 1 case happened esophageal perforation. Conclusion Endoscopic therapies including balloon dilatation or microwave coagulation plus balloon dilatation were efficacious to esophageal stenosis caused by various causes.

AIM: To identify the changes in microRNA ( miRNA ) profile of human lens epithelium ( HLE) induced by H2 O2 and the role of miRNA in oxidative stress induced apoptosis.
METHODS: HLE cell line HLE - B3 was treated by 100μmol/L H2 O2 for 24h and the total RNA were isolated by Trizol reagent. miRNA profile was generated by miRCURYTM LNA microRNA Array. The target genes of differentially expressed miRNAs were predicted by bioinformatics software.
RESULTS:Twenty-eight miRNAs showed significantly differential expression after H2 O2 treatment, 18 miRNAs upregulated and 10 miRNAs downregulated. The differentially expressed miRNAs may involve in apoptosis of lens epithetium and development of cataract through targeting BCL2L2 and MIP.
CONCLUSION: H2 O2 can induce dramatically changes in miRNA profile of HLE, which may play a pivotal role in the pathogenesis and development of cataract.

Child ; Humans ; Male ; Melanoma ; Melanosis ; Meningeal Neoplasms ; Neurocutaneous Syndromes

Humans ; Neoplasms ; therapy ; Receptor, Epidermal Growth Factor