To explore the of occupational therapy for the cerebral palsied children was introduced. The assessment areas of occupational therapy and evaluational instruments commonly used. The last part gives the concrete treatment methods that occupational therapy usually adopts in practice, specially in the fields of training and developing the grass motor skills of the upper limbs, the fine motor skills of the hands and ADL skills of the children with cerebral palsy were also stated.

Objective To evaluate the effect of the Danhong injection combined with irbesartan in treatment ofearly diabetic nephropathy. Methods 64 patients with early diabetic nephropathy were randomly divided into two groups and the control group 32 cases,two groups were given control of blood sugar and ensure water and electrolyte balance,support therapy,in which 32 cases were also observed red Danhong injection,Ecuador irbesartan treatment,2weeks before evaluation. Results The total effective rate in treatment group was higher than the control group( x2 =6.38 ,P ＜0. 05) ,after 12 weeks of treatment,two groups of urinary protein decreased significantly compared with before treatment, including observation of urine protein was ( 0. 6± 0. 1 ) g/24h, the control group was ( 0. 7 ± 0. 3 ) g/24h,and decreased urine protein level of the observation group was better than the control group( t = 2. 74,P ＜ 0. 05 ). And in the course of treatment, side effects and serious adverse events were not found. Conclusion Danhong injection combined irbesartar, could improve the clinical symptoms, reduce microalbuminuria in treatment of early diabetic nephropathy is worthy of wider application.

Objective To investigate the expression of large-conductance calcium-sensitive potassium channel (BKCa) in myometrium.Methods The expression levels of BKCa ? subunit protein in human myometrium tissues in term of non-labor(TNL) and term labor(TL)were measured by Western blot analysis. Results Relative abundance of BKCa channel ? subunit protein was 1.18+0.20 for TNL group(n=9),and 0.60+0.08 for TL group(n=11).The statistic difference was significant (P=0.009). Conclusion Expression of BKCa channel protein in lower segment myometrium of TNL group was higher than that of TL group. BKCa may play a certain role in modulating uterine function.

Objective: To explore the chemical-biological assay pattern for quanlity control and evaluation of Chinese materia medica solid preparations (CMMSP). Methods: MTT assay was used to obtain the characteristic cell inhibitory rate on LX-2 hepatic stellate cells by Compound Biejia Ruangan Tablet (CBRT) dissolving solutions in PBS dissolution medium with pH 7.4 for different time periods. From these results, the cumulative dissolution of CBRT was obtained based on the cell inhibitory rate. The dissolution rates of paeoniflorin, phillyrin, and ginsenosides Rg1 were determined by HPLC method. A novel approach of self-defined weighting coefficient based on the quality had been created to establish the integrated dissolution rate model. Then f2 similar factor method was used to evaluate the relevance of these two methods. Results: The f2 values for paeoniflorin, phillyrin, ginsenosides, and the integration dissolution were 43, 58, 61, and 59, respectively. It was indicated that the dissolution of multicomponent integration could fully reflect the biological potency of all parties. Conclusion: The biological activity-multicomponents integrated evaluation method of dissolution is expected to be one of the effective means for in vitro dissolution test of CMMSP.

Foreign Bodies ; complications ; diagnosis ; Glottis ; Hoarseness ; diagnosis ; etiology ; Humans ; Male ; Middle Aged

Objective To investigate current health status of medical professionals in Guangdong Province to provide evidence for individualized health management. Methods Based on multi-stage stratified sampling method,3872 medical professional from 56 hospitals in Guangdong Province were enrolled and completed a self-designed questionnaire. The results were collected and compared using descriptive analysis, K-S test, Chi-square test and multivariate Logistic regression. Results A total of 3687 (95.2%) feed-backs were collected,of which 3502 (95.0%) could be used. Insomnia was the most serious problem among nurses (68. 9% ). The incidence rate of sub-health condition was 58. 2%. First-line clinical work,female, long working experience, tertiary hospital, no physical activity and insomnia were correlated with more serious sub-clinical health. Conclusion Unhealthy life style and sub-heahh problems negatively impact health of medical professional. Therefore, supervisors should pay more attention to those with certain characteristics.

Objective In order to investigate the interactions between the activities of daily living of children with post poliomyelitis and depression of their parents.Method 40 cases whose children were with post poliomyelitis were tested by SDSCR.Children's activity of daily living were tested with Barthel's index.Result 65％ of parents whose children with post polimyelitis were depression.Their symptoms of depression were mainly moderate level.There are marked difference comparing with the domestic normal analyzing model.The activities of daily living of the post poliomyelitis's children was worse,the older their parent's age was the higher the incidence of depression occurred was.Conclusion We should pay attention to their parents emotion changes when we carry out the community rehabilitation of post poliomyelitis's children,and strive them for positive coperating our rehabilitation training.

Objective To assess the effect of intraperitoneal interstitial implant of Sustained-release 5-Fluorouracil during operation for advanced rectal cancer. Methods One hundred and four cases with advanced rectal cancer were enrolled into the study and divided into 3 groups: treatment group 1(n = 37), underwent combined hypotonic peritoneal chemo-hyperthermia and Sustain-released 5-fluorouracil implantation treatment during operation; treatment group 2(n = 34), underwent combined intraoperative hypotonic peritoneal chemohyperthermia and early postoperatively intraperitoneal chemotherapy treatment; and control group(n = 33),underwent peritoneal lavage during radical resection alone. Results Digestive tract toxicity in group 1 was significantly lower than that in group 2(2. 70% vs. 20. 59%, x2 = 9. 104, P ＜ 0. 05). There were significant difference on 1 year survival rate among the three groups. The 2-year survival rate of group 1 was significantly higher than that in the control group (78. 37% vs. 48. 48%, x2 = 1. 297 ,P ＜ 0. 05). After two years follow-up the 2-year local recurrence rate of group 1 was significantly lower than that in the control group(21.62% vs 32. 35 %, x2 = 7. 001, P ＜ 0. 05). However, no significant difference was found compared to group 2, which was 32. 35%. Conclusion lntraperitoneal interstitial implant of Sustain-released 5-Fluorouracil during operation is an effective intraperitoneal chemotherapy with mild side effects for advanced rectal cancer.

Objective To explore the influence of family factors on physical activity behavior of central obesity patient.Methods A questionnaire investigation to 182 central obesity volunteers was carried out in a residential district of shanghai on April 2007.Results The percentage of the patients taking physical activities,at least one of whose family members participate in regular exercise,was 66.7%.It was significantly higher than that (43.6%) of other patients whose family members hardly ever participated in regular exercise any more(χ2=9.260,P=0.002).The percentage of patients taking physical activities,with highly family function,was 60.2%.It was significantly higher than that of the patients in moderately dysfunctional family (49.9%) and in severely dysfunctional family(35.5%)(χ2=6.448,P=0.04).The average APGAR score,Partnership score and Growth score of the patients in taking exercise group were 7.13±2.63,1.49±0.71 and 1.35±0.73. They were significantly higher than that of the patients in taking no exercise group (6.09±3.09,1.24±0.85 and 0.90±0.86) (t=2.095～3.845,P=0.000～0.038). While family size,family economic status and marital status showed no obvious effect on physical activity behavior of central obesity patients(χ2=0.027～1.709,P＞0.05).Conclusion Highly family function and at least one of the other family members taking regular exercise can promote activity of central obesity patient in daily life.

Objective To investigate the effect of pioglitazone on the expression of thrombospondin-1(TSP1)and transfor ming growth factor-β1 (TGF-131)in the kidney of diabetic rats.Methods Forty Sprague-Dawley(SD)rats were randomly divided into 4 groups:normal control(NC),streptozocin-induced diabetic mellitus(DM),diabetic rats treated with pioglitazone(DP)and normal control rats treated with pioglitazone(NP).24-h urine protein quantity,serum creatinine(Scr) and kidney hypertrophy index were measured after treatment for 10 weeks,and the expression of TSP1 and TGF-β1 in the kidney was detected by using RT-PCR and immuohistochemistry.Results As compared with DM group,urine protein level and kidney hypertrophy index were significantly attenuated in DP group(P<0.05),but there was no significant difference in plasma glucose between them(P>0.05).As compared with NC and NP groups,the expression of TSP1 and TGF-β1 was significantly elevated in the kidney of DM and DP groups(P<0.01).Both TSP1 and TGF-β1 expression in DP group was lower than in DM group(P<0.05).Conclusion Pioglitazone can exert a direct protective effect on the kidney in diabetic rats,which is independent of the role of insulin sensitizer,and the mechanism may be associated with the decreased TSP1 expression in the kidney.