1.A Psychobiographical Study of Lu-Xun’s Personality
Jianren ZHANG ; Jinbiao ZHOU ; Hui LING
Chinese Journal of Clinical Psychology 2001;0(03):-
Objective: This article combined the methods of quantitative and qualitative research to probe Luxun’ personality characteristics.Methods: Elevn Literature college teachers of Hunan normal university evaluated Luxun’ personality characteristics used the Adjective Checklist of Personality.Results: 29 adjective words were selected as fit Luxun’s personality.Cluster analysis to this 29 words showed that they may be grouped into three types: "Independently striving to improve","Self-respect and stubborn","lonely and radicalization".The method of psychobiographical analysis to Luxun’ personality showed that the childhood experience,solution to identity crisis had great influention on the development of Luxun’s personality.Moreover,through applying the Psychoanalysis,we inferred that Luxun has inferiority complex.Conclusion: Luxun’s personality’s development were influenced by many factors,like childhood experience,family’s status,his social experience and enrironment and so on.
2.Overexpression of ?-Synuclein Gene Caused Dopaminergic Neuron Damage in Substantia Nigra of Rats
Ling-Ling LU ; Ai-Xia ZHOU ; Hui YANG ;
China Biotechnology 2006;0(01):-
Objectiive:The present study was designed to explore whether overexpression of human wild ?-synuclein in rat brain caused selective dopaminergic neuron loss in substantia nigra and aimed to find out a new method to make a rat model of Parkinson's disease(PD).Methods:The human wild ?-synuclein gene was induced into the rat brain by Adeno-Associated Virus(AAV) vector.The overexpression of ?-synuclein was detected by realtime PCR.The behavior of rats were recorded every 4 weeks after the viral particle injection.TH immunohistochemistry were performed at 4,8,12 and 16 weeks post-injection as well as the dopamine(DA),3,4-dihydroxypheny-lacetic acid(DOPAC) of striatum were determined by high performance liquid chromatography coupled with electrochemical detection.Results:Realtime PCR results revealed a significant overexpression of ?-synuclein in the injected hemisphere.By 8 weeks post injection,a significant loss of the dopaminergic neurons was observed.34% of the dopaminergic neurons were lost after 12 weeks,and about 60% cells loss after 16 weeks.The DA and DOPAC levels in the striatum decreased about 15% 12 weeks after injecting viral particle carried ?-synuclein gene and 30% decreased after 16 weeks.The AAV-?-synuclein-treated rats developed a type of motor impairment,i.e.,head position bias,compatible with this magnitude of nigrostriatal damage.Conclusion:All the results showed that overexpression of human wild ?-synuclein caused selective dopaminergic neuron loss and mimic a symptom of human PD in rats.This may be a new methed to make rat PD model which can offer new opportunities for the study of pathogenetic mechanismsand exploration of new therapeutic targets of particular relevance to human PD.
3.Analysis of national surveillance on Kaschin-Beck disease condition from 2000 to 2007
Hui, LIU ; Ling-wang, ZHOU ; Yun-qi, LIU
Chinese Journal of Endemiology 2009;28(5):554-556
Objective To investigate the trend of the national Kaschin-Beck disease condition, and provide the scientific basis for the government to make preventing strategy. Methods The data were collected from national surveillance on Kaschin-Beck disease(KBD) condition from 2000 to 2007 by restrospective method. The national X-ray detective rates and KBD condition in the eastern and western areas of China were analyzed. Results Monitoring data were collected from 189 monitoring points in 14 provinces of China, and 21 287 X-ray films were photographed of right hands of children from 2000 to 2007. X-ray detective rate was decreased significantly of national KBD from 2000 to 2007. The condition in the west of China is slightly more serious than the eastern areas, but the average of X-ray detective rate was also decreased from 21.75% to 7.30%. National condition is basically controlled. X-ray detective rate had been controlled below 5%, exept for Qinghai, Tibet and Inner Mongolia and so on. Conclusions Ninty percent of the wards have reached the controlled level according to the X diagnosis standard. In terms of the severity of the disease, most of the wards are occupied by patients with slight condition, 10% ward with moderate condition, less than 1% ward with serious condition.
4.MRI Features and the Guiding Value for Operation of Cranial Base Chordoma.
Qiuhua ZENG ; Hui WANG ; Dongjing ZHOU ; Yitai LING
Journal of Medical Research 2006;0(10):-
Objective To explore the guiding value for operation of MRI in diagnosing the cranial base chordoma. Methods MRI features of 15 cases with cranial base chordoma, which were proved by biopsy and surgery, were retrospectively analyzed. Results Most of the cranial base chordoma were located in the middle area of the skull base such as clivus and sellar region and always invaded extensively the nerves and major intracranial vessels of skull base. All tumors were hypointense on T_2WI and enhanced more markedly, but steady heterogeneous. Conclusion MRI examination is of great clinical signifiance in delineating the location, size and extension of cranial base chordoma, and showed anatomic relation with surrounding structures such as the major intracranial vessels of skull base, which is very important in surgical planning.
5.DETERMINING THE CONTENT OF JASMINODIN IN MEI RONGCAPSULE WITH THIN LAYER CHROMATOGRAPHY
Hui MU ; Lin LI ; Ling ZHOU ; Xiaoli WAN ; Senke HU
Journal of Pharmaceutical Analysis 2001;13(1):81-82
Objective Jasminodin in Mei Rong capsule was determined by the method of thin layer chromatography. Methods The sample jasminodin was extracted with methanol and then the extract was chromatographed on silica gel GF254 plate with chloroform-methanol-water (10:3:1) as mobile phase and the chromatograms were scanned by using Shimadzu CS-930 dual wavelength TLCS in zegzag scanning mode at λs 370nm and λR 250nm.Results Calibration graph was rectilinear between 2.7μg~16.2μg per spot for the jasminodin. Conclusion Satisfatory results were obtained with the average recovery ratio of 99.76% ,RSD 2.27%.
6.Report of a case with Paget disease with bilateral progressive hearing loss as the first symptom.
Li MENG ; Hui-Fang ZHOU ; Jian-Ling WANG
Chinese Journal of Otorhinolaryngology Head and Neck Surgery 2009;44(7):602-603
Aged
;
Female
;
Hearing Loss, Bilateral
;
diagnosis
;
etiology
;
Humans
;
Osteitis Deformans
;
complications
;
diagnosis
7.Primary maxillary sinus tuberculosis misdiagnosed as fungal sinusitis: a case report.
Jian-ling WANG ; Hong ZHU ; Hui-fang ZHOU
Chinese Journal of Otorhinolaryngology Head and Neck Surgery 2011;46(8):685-686
Diagnostic Errors
;
Female
;
Humans
;
Middle Aged
;
Mycoses
;
diagnosis
;
Paranasal Sinus Diseases
;
diagnosis
;
Sinusitis
;
diagnosis
;
Tuberculosis
;
diagnosis
8.Correlation analysis of efficacy of yiqi chutan recipe in treating NSCLC and P4HB expression.
Ling-ling SUN ; Li-zhu LIN ; Jing-xu ZHOU ; Zhuang-zhong CHEN ; Wen-hui TAO
Chinese Journal of Integrated Traditional and Western Medicine 2015;35(2):184-187
OBJECTIVETo study the predicting effect of proly 4-hydroxylase beta polypeptide (P4HB) in treating non-small cell lung cancer (NSCLC) patients by Yiqi Chutan Recipe (YCR).
METHODSTotally 46 stage III and IV NSCLC patients were treated by YCR for 4 therapeutic courses. Effect was assessed by RECIST of solid tumor. P4HB expression was detected in the lung cancer tissue by immunohistochemical assay. Factors affecting disease control rates (DCR) of YCR were analyzed by Logistic regression analysis. The correlation between P4HB expression and the effect of YCR was analyzed.
RESULTSThe DCR of advanced NSCLC treated by YCR was 36.96% (17/46 cases). P4HB was high expressed in advanced lung cancer tissue (6/15 cases). Gender, initial treatment, and retreatment are independent factors for affecting DCR of treating lung cancer by YCR.
CONCLUSIONP4HB might be taken as a factor for predicting the effect of YCR in treating NSCLC.
Carcinoma, Non-Small-Cell Lung ; drug therapy ; metabolism ; Drugs, Chinese Herbal ; therapeutic use ; Humans ; Lung ; Lung Neoplasms ; drug therapy ; metabolism ; Male ; Procollagen-Proline Dioxygenase ; metabolism ; Protein Disulfide-Isomerases ; metabolism
9.Observation on effect characteristics of electroacupuncture for different types of functional constipation.
Hui-Fen ZHOU ; Shu-Qing DING ; Yi-Jiang DING ; Ling-Ling WANG ; Hui LIU ; Jian FANG ; Xu YANG
Chinese Acupuncture & Moxibustion 2014;34(5):435-438
OBJECTIVETo explore the differences of electroacupuncture (EA) on onset time and symptom improvement for treatment of different types of functional constipation.
METHODSThirty-eight cases of constipation were selected, including 9 cases of constipation-predominant irritable bowel syndrome (IBS-C), 10 cases of slow transit constipation (STC), 10 cases of pelvic floor dyssynergia (PFD) and 9 cases of inadequate defecatory propulsion (IDP). The electroacupuncture was applied at Tianshu (ST 25), Fujie (SP 14), Shenshu (BL 23), Dachangshu (BL 25) and so on in abdominal and lumbosacral area, 5 times per week, 10 times as a treatment course. The onset time, score of clinical symptoms of constipation and improvement of every symptom in each group were compared.
RESULTS(1) The onset time was (1.78 +/- 0.83) days in IBS-C type, (3.11 +/- 1.90) days in IDP type, (4.10 +/- 1.85) days in STC type and (4.30 +/- 2.00) days in PFD type, indicating statistical differences between IBS-C type and STC type, IBS-C type and PFD type (both P < 0.05). (2) Compared before the treatment, the total scores of symptoms on the onset day in each group were all improved (P < 0.05, P < 0.01), and score of IBS-C type was superior to the rest 3 types (P < 0.05, P < 0.01). (3) EA improved desire to defecate or frequency of defecation in each type (P < 0.05, P < 0.01), in which both were improved in STC type and PFD type, and the improvement of defecation frequency was more significant in STC type (P < 0.01). EA relieved unsmooth defecation or pendant-expansion feeling in each type (all P < 0.05), in which both were improved in IBS-C type (both P < 0.05). EA relieved abdominal distension and pain in IBS-C type, STC type and PFD type (all P < 0.05), while its effects were not obvious on defecation difficulty, defecation time and defecation texture (all P > 0.05).
CONCLUSIONThe electroacupuncture for treatment of 4 types of constipation is characterized by rapid onset; the improved symptoms are not identical in the electroacupuncture treatment plan for each type of defecation; the main improvement of symptoms are lied on desire to defecate and frequency of defecation, unsmooth defecation or pendant-expansion feeling and abdominal distension and pain. Meanwhile the improvements of defecation texture, defecation difficulty and defecation time were not signi-ficant.
Adult ; Aged ; Constipation ; etiology ; physiopathology ; therapy ; Defecation ; Electroacupuncture ; Female ; Humans ; Irritable Bowel Syndrome ; complications ; Male ; Middle Aged ; Pelvic Floor Disorders ; complications ; Treatment Outcome ; Young Adult
10.The effect of matrine on adriamycin-induced podocyte injury and the function of mTOR signaling pathway
Xiaoju ZHOU ; Yuning LI ; Weiguo LI ; Xiumin ZHANG ; Jizu LING ; Hui YANG ; Hui XU ; Xiangjin LI
Journal of Clinical Pediatrics 2013;(8):757-761
Objectives To investigate the effect of matrine (MAT) on adriamycin (ADR) induced podocyte injury in vitro and explore the function of the mammalian target of rapamycin (mTOR) protein signaling pathway during the intervention. Methods ADR (1μmol/L) was used to induce the model of podocyte injury and then the podocytes were intervened by 10, 20 and 40μg/ml MAT for 24 hours. The viability and apoptosis rate of podocytes, mRNA and protein expressions of desmin and mTOR were detected. The effect of different concentrations of MAT on ADR-induced podocytes was analyzed. Results Com-pared with the control group, declined viability of podocytes (P<0.001), increased percentage of apoptotic podocytes (P<0.001), and increased expression of damage marker desmin (P=0.002) were observed in ADR group. In ADR group, after intervention with MAT of 10-40μg/ml, increased viability of podocytes (P<0.05), decreased percentage of apoptotic podocytes (P<0.05), and decreased expression of damage marker Desmin were found (P<0.05). The protein expression of mTOR and phosphorylation state of mTOR (p-mTOR) decreased in ADR induced-podocytes (P<0.05), and after intervention with MAT of 10-40μg/ml, the expression of mTOR and p-mTOR increased (P<0.05). The expression of mTOR downstream target protein s6k1 and 4EBP1 mRNA decreased in ADR group (P=0.071), while increased after intervention with MAT of 10-40μg/ml (P<0.05). Conclusions 10-40μg/ml MAT have protective effects on ADR-induced podocytes in vitro. The protection mechanism may be related to mTOR signaling pathway.