1.Tumor mass of ovary.
Ling-fei KONG ; Ping-zhang YIN
Chinese Journal of Pathology 2008;37(4):278-279
2.Granulocytic sarcoma of uterine cervix: report of a case.
Qiu-Yu LIU ; Mei XU ; Yuan-Rui HAO ; Li LI ; Ling-Fei KONG
Chinese Journal of Pathology 2010;39(11):773-774
Adult
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Carcinoma, Small Cell
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metabolism
;
pathology
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Diagnosis, Differential
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Female
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Follow-Up Studies
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Humans
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Hysterectomy
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Leukosialin
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metabolism
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Lymphoma
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metabolism
;
pathology
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Peroxidase
;
metabolism
;
Sarcoma, Myeloid
;
metabolism
;
pathology
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surgery
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Uterine Cervical Neoplasms
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metabolism
;
pathology
;
surgery
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Uterine Cervicitis
;
metabolism
;
pathology
3.Metanephric stromal tumor: report of a case.
Fang-fang GUO ; Kai-yan WU ; Ying REN ; Li-fu WANG ; Ling-fei KONG
Chinese Journal of Pathology 2010;39(9):632-633
Adenofibroma
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metabolism
;
pathology
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Antigens, CD34
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metabolism
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Child, Preschool
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Diagnosis, Differential
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Female
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Humans
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Kidney Neoplasms
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metabolism
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pathology
;
surgery
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Neoplasms, Germ Cell and Embryonal
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metabolism
;
pathology
;
surgery
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Nephroma, Mesoblastic
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metabolism
;
pathology
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Sarcoma, Clear Cell
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metabolism
;
pathology
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Stromal Cells
;
metabolism
;
pathology
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Vimentin
;
metabolism
4.Correlation between thyroid function and glucolipid metabolism in type 1 diabetic adults
Yiping CHENG ; Xinli ZHOU ; Fei JING ; Lei KONG ; Ling GAO ; Qingbo GUAN ; Jiajun ZHAO ; Chao XU
Chinese Journal of Internal Medicine 2021;60(1):51-54
To assess the correlation between thyroid function and glucolipid metabolism in type 1 diabetic adults. A retrospective analysis was conducted in 230 type 1 diabetic adults who were hospitalized in the Department of Endocrinology of Shandong Provincial Hospital Affiliated to Shandong University from January 2008 to January 2020. It showed that thyroid stimulating hormone(TSH) was significantly positively correlated with total cholesterol (TC) ( r=0.239), triglycerides (TG) ( r=0.166) and low-density lipoprotein cholesterol (LDL-C) ( r=0.249), respectively (all P<0.05). Free triiodothyronine (FT 3) was significantly negatively correlated with fasting plasma glucose (FPG) ( r=-0.272), glycated hemoglobin (HbA1c) ( r=-0.240), TC ( r=-0.197) and LDL-C ( r=-0.220), respectively (all P<0.05). Free thyroxine (FT 4) was negatively correlated with TC ( r=-0.171) and LDL-C ( r=-0.170), respectively (all P<0.05). TC was an independent predictor of TSH, FT 3 and FT 4, FT 3 and FT 4 were independent predictors of HbA1c. TSH was an independent predictor of TC, TG and LDL-C. Thyroid function is closely related to glucolipid metabolism in type 1 diabetic adults.
5.Studies on the chemical constituents of Cirsium japonicum DC.
Fei ZHI ; Ling-yi KONG ; Si-xun PENG
Acta Pharmaceutica Sinica 2003;38(6):442-447
AIMIn order to look for new bioactive compounds, investigation on the chemical constituents, especially on the typical polyacetylenes from the rhizomes of Cirsium japonicum DC. was carried out.
METHODSChromatographic techniques including silica column chromatography and preparative silica thin-layer chromatography were used to separate and purify the constituents. Their structures were elucidated by physicochemical properties and spectral analyses including UV, IR, 1HNMR, 13CNMR, HMQC, HMBC and HREIMS.
RESULTSTwelve compounds were isolated from the rhizomes of Cirsium japonicum DC., and their structures were identified as cis-8, 9-epoxy-heptadeca-1-ene-11, 13-diyne-10-ol (1), ciryneol A (2), 8,9,10-triacetoxyheptadeca-1-ene-11,13-diyne (3), ciryneone F (4), cireneol G (5), ciryneol H (6), ciryneol C (7), p-coumaric acid (8), syringin (9), linarin (10), beta-sitosterol (11) and daucosterol (12).
CONCLUSIONCompounds 4, 5 and 6 are new compounds, compound 3 is a new natural product and compound 8 was isolated from this plant for the first time.
Cirsium ; chemistry ; Drugs, Chinese Herbal ; chemistry ; isolation & purification ; Molecular Conformation ; Molecular Structure ; Plants, Medicinal ; chemistry ; Rhizome ; chemistry
6.HPLC-MS3 analysis of chemical constituents in Epimedium brevicornum.
Peng-fei LIU ; De-ran XU ; Ling-yi KONG
China Journal of Chinese Materia Medica 2007;32(16):1666-1668
OBJECTIVETo investigate the chemical constituents of effective part of Epimedium brevicornum.
METHODThe sample was extracted with ethanol and purified by macroporous resin. The structures were identified by HPLC-MS3 experiments.
RESULTNine compounds were identified from the effective part of E. brevicornum.
CONCLUSIONThe method is simple and rapid for the identification of the flavonoids from E. brevicornum.
Chromatography, High Pressure Liquid ; methods ; Drugs, Chinese Herbal ; chemistry ; isolation & purification ; Epimedium ; chemistry ; Flavonoids ; chemistry ; isolation & purification ; Molecular Structure ; Plants, Medicinal ; chemistry ; Reproducibility of Results
7.Clinicopathologic features of mammary analogue secretory carcinoma of salivary glands
Lei ZHANG ; Jian-Guo WEI ; Mei XU ; Ling-Fei KONG
Chinese Journal of Clinical and Experimental Pathology 2018;34(2):187-190
Purpose To summarize the clinicopathological features, immunophenotype, diagnosis and differential diagnosis of mammary analogue secretory carcinoma of salivary glands(MASC). Methods Four cases of MASC were included. The clinical, histological, and immunohistochemical features and follow-up data were evaluated. Results The patients aged between 20 to 72 years. Two cases were male and two were female. The average age was 52.2 years. All cases showed infiltrative growth and diverse cytology and histology, including lobular, cystic papillary, solid, cribriform or glandular structures, and microcystic honeycombed pattern composed of small cysts merged into larger cysts resembling thyroid follicles. There were no necrosis, nerve or vascular invasion in 4 cases. S-100 protein, Mammaglobin or SOX10 were strongly positive in all MASC cases.3 cases were insignificant positivity for GATA-3. Both p63 and DOG-1 were negative. Conclusion MASC is a lowgrade malignant epithelial tumor of salivary glands. Combined immunohistochemical positivity of S-100 protein, Mammaglobin and SOXIO, or negative for DOG-1, are useful in the diagnosis and differential diagnosis of MASC.
8.Kaposiform hemangioendothelioma: a clinicopathological analysis of 29 cases
Lei ZHANG ; Jian-Guo WEI ; Meng HOU ; Ling-Fei KONG
Chinese Journal of Clinical and Experimental Pathology 2018;34(3):295-299
Purpose To explore the clinicopathologic features, diagnosis and differential diagnosis of Kaposiform hemangioendothelioma. Methods To reported the histopathological and immunohistochemical features in 29 cases of Kaposiform hemangioendothelioma, combined with the clinical data and the literature review. Results Of the 29 patients, 15 were male and 14 were female, almost all patients were no more than 1 year old, except one patient aged 25 years.28 cases occurred in superficial skin, including 15 cases in limbs, 5 cases in head and neck, 4 cases in trunk, 1 case in armpit, 3 cases were multiple sites, and 1 case in pelvic cavity. The clinical manifestations were limited or diffuse skin painless plaque, and 16 cases with Kabasach-Merritt phenomenon. Microscopically, the tumor was composed of proliferating small blood vessels and spindle cells, with irregular nodular or lobulated distribution, and invasive growth. Spindle cells were arranged in bundles, with epithelioid cells and spindle cells arranged in nests, and glomerulus-like structures, and the latter with crescent shaped vascular fissures. Immunohistochemically, the tumor cells were strongly positive for VEGFR-3, CD31, CD34 and ERG. Partial tumor cells were positive for SMA and D2-40, but negative for CK, Glut-1 and HHV8. Conclusion Kaposiform hemangioendothelioma is a rare, intermediate, locally aggressive angiogenic tumor, mainly occurring in infants and young adults. The diagnosis relies on its unique morphology and immunophenotype, and it should be differentiated from tufted angioma, infantile hemangioma, congenital hemangioma, spindle cell hemangioma, verrucous venous malformation and Kaposi sarcoma. Extended resection is the best way to treat Kaposiform hemangioendothelioma.
9.Effects of aqueous extract in herba of Lysimachia christinae on hyperuricemia in mice.
Hai-dong WANG ; Fei GE ; Yu-song GUO ; Ling-dong KONG
China Journal of Chinese Materia Medica 2002;27(12):939-944
OBJECTIVETo study hypouricemic effect of aqueous extract of Lysimachia christinae on hyperuricemia in mice.
METHODThe uricase inhibitor potassium oxonate was used to induce hyperuricemia in mice, and serum uric acid level was determined with the phosphotungstic acid method.
RESULTThe aqueous extract of Lysimachia christinae, when administered orally to the oxonate-induced hyperuricemic mice at the doses of 5.2, 10.4 and 20.8 g.kg-1, was able to elicit dose-dependent hypouricemic effects. At these doses of the extract, the serum urate levels of the oxonate-pretreated mice showed no difference from the normal mice. In normal mice, however, oral administration of the extract at the same doses did not produce any observable hypouricemic effects.
CONCLUSIONThe aqueous extract of Lysimachia christinae possesses potent hypuricemic effects on models of hyperuricemia in mice pretreated with oxonate.
Animals ; Drugs, Chinese Herbal ; isolation & purification ; pharmacology ; Female ; Hyperuricemia ; blood ; Mice ; Plants, Medicinal ; chemistry ; Primulaceae ; chemistry ; Uric Acid ; blood
10.Relationship between low-grade squamous intraepithelial lesions and high risk human papillomavirus
Ya-Ping XING ; Xiao-Xia SONG ; Yan-Zhi DING ; Ling-Fei KONG
Chinese Journal of Clinical and Experimental Pathology 2017;33(12):1356-1359
Purpose To study the infection mode and distribution of high risk human papillomavirus (HR-HPV) in lowgrade squamous intraepithelial lesions (LSILs) and to analysis its effect.Methods HPV genotype of 328 cervical tissues embedded by paraffin which contained 168 LSILs and 160 highgrade squamous intraepithelial lesions (HSILs) were detected by the methods of real-time fluorescence quantitative PCR and in situ hybridization.Results Diseased cells of LSIL stained with hematoxylin and eosin(HE) were concentrated in the upper layer of the cervical squamous epithelium,whereas HSIL were concentrated in the lower layer of the epithelium in HE staining.In LSIL,the positive ratcs of HR-HPV was 95.2%.In LSIL and HSIL,HPV 16/18 positive rates were 26.2%,57.5%,respectively.Other HR-HPV positive rates were 80.9%,55.0%,respectively.The differences were statistically significant (P <0.001).HR-HPV positive rate was 70.2% in the group of in situ hybridization.The positive cells were confined to the surface and middle layer of the LSIL cervical squamous epithelium.Conclusion HR-HPV infection is closely related to LSIL,especially other HR-HPV (except for HPV 16/18).The infection mode of HR-HPV in LSIL starts from the surface layer of the cervical squamous epithelium.