Objective:To elucidate the effect of osteogenic growth peptide(OGP) on proliferation and protein synthesis of human PDLCs in vitro.Methods:Human PDLCs were cultured individually in medium contained various concentrations of OGP;and cell proliferation quantity and protein synthesis were examined by MTT and coom asie brilliant blue staining.Results:In vitro,the addition of OGP in cultures resulted in an increase of cell proliferation(P

One hundred and nine cases of female isosexual precocious puberty were reported. Among them 63 cases were true precocious, while 48 pseudoprecocious. Based on the analysis of their clinical characteristics, the etiologic classification and the differentiation between true and pseudo precocious puberty were discussed. In 43 cases of true precocious puberty, Chlormadinone was used without any influence on growth. It was effective to control the menstruation and the development of secondary sexual characteristics in all but two cases who were over 8 years old. Besides, the problem of the final height of precocious girls was also discussed.

Comprehensive evaluation for colleges of stomatology is a complex systematic engineering, which is affected by the determination of index and weight. Based on the previous research results,this study establishes a comprehensive evaluation index for colleges of stomatology in China by applying Delphi method,carrying out two-round consultation to 45 experts,which includes 4 first layer indicators and 21 second layer indicators.

In recent years,cellular immune therapy represented by antigen-chimeric receptor T cells (CAR-T) has made a great breakthrough in the treatment of hematological malignancies.T memory stem cells (TSCM) and central memory T cells (TCM) can be used as most powerful carrier for T cell immunotherapy,however,how to regulate their differentiation in vitro and in vivo as well as how to construct a strong treatment system while without potential side effect become quite interesting.This article summarized the studies from the 58th America Society of Hematology Annual Meeting regarding to values and associated research progress about TsCM and TCM in hematological malignancies.

Objective:To explore the influencing factors on patients' health seeking behavior in rural China by employing the theory of planned action.Methods:Data from cross-sectional household-based health survey carried out in 2008 were used in the study.Correlations between outcomes and explanatory variables were studied by Logistic regression.Results:The studying population included 19 389 adult patients over the age of 15.Illness awareness,medical experience and structural restriction factors had strong effect on whether the patients chose medical service.Pepople in different socioeconomical status suffered different influences.Conclusion:Responding to the changing trend of health service demand among rural residents,we should recognize the differentiation and allocate the healthcare resources more rationally.

Objective : To investigate the spatiotemporal clustering characteristics of hand, foot, and mouth disease in Shangcheng District, Hangzhou City in 2021, so as to provide insights into prevention and control of hand, foot, and mouth disease. Methods: Data pertaining to the incidence of hand, foot and mouth disease in Shangcheng District in 2021 were collected from Chinese Disease Prevention and Control Information System, spatial and temporal distribution of hand, foot and mouth disease were described, and the spatiotemporal clusters were identified. Results: A total of 2 473 cases with hand, foot and mouth disease were reported in Shangcheng District in 2021, with a reported incidence rate of 186.86/105. The incidence of hand, foot and mouth disease appeared a bimodal distribution, with the first peak seen during the period between May and July (1 164 cases, 47.07%) and the second peak during the period between October and December (659 cases, 26.65%). Hand, foot and mouth disease was reported across all streets in Shangcheng District, with the highest incidence seen in Dinglan Street (398.84/105). There were one primary cluster and ten secondary clusters of hand, foot and mouth disease, and the primary cluster was centered in Jianqiao Street with 1.81 km in radius, which covered 9 communities in Jianqiao Street and was clustered during the period from March 19 and April 13. Of the 10 secondary clusters, there were three clusters in Dinglan Street, one in each of Jiubao, Sijiqing, Wangjiang and Kaixuan streets, and three clusters crossing streets. In addition, no spatiotemporal clusters of hand, foot and mouth disease were identified in Nanxing Street, Qingbo Street or Ziyang Street. Conclusion There was a remarkable spatiotemporal cluster in the incidence of hand, foot and mouth disease in Shangcheng District in 2021, with the peaks in incidence from May to July and from October to December, and the incidence of hand, foot and mouth disease was mainly clustered in the urban-rural junction and the central urban regions.

OBJECTIVE:To make a systematic review on the efficacy and safety of canagliflozin in the treatment of type 2 dia-betes,and to provide evidence-based reference for clinical treatment. METHODS:Retrieved from Cochrane Library,PubMed,EM-Base,CBM and Wanfang database,randomized controlled trials (RCT) of canagliflozin (test group) versus placebo (control group)in the treatment of type 2 diabetes were collected,and Meta-analysis was performed by using Rev Man 5.2 statistical soft-ware after extracting data and evaluating quality. RESULTS:A total of 7 RCTs were included,involving 2 188 patients. The results of Meta analysis indicated that glycosylated hemoglobin levels [WMD=-0.82,95%CI(-0.99,-0.65),P<0.001],the proportion of HbA1c<7%[RR=2.51,95%CI(1.98,3.19),P<0.001],fasting plasma glucose levels [WMD=-32.91,95%CI(-39.65,-26.17), P<0.001] in test group were significantly better than those of control group,the incidence of genital tract infections was significant-ly higher than control group [RR=3.76,95%CI(2.23,6.35),P<0.001];however,compared with control group,there was no sig-nificant difference in the incidence of hypoglycemia [RR=1.13,95%CI(0.40,3.20),P=0.81] and urinary tract infections[RR=1.19,95%CI(0.82,1.73),P=0.36]. CONCLUSIONS:Canagliflozin is safe and effective in the treatment of type 2 diabetes,and it needs to be noticed with genital tract infections during the clinical use. Due to the limitation of methodology,large-scale and poly-centric RCT are required for further validation of the conclusions.

Objective To observe the characteristics of electrocardiographic parameters of the right heart in the early newborns with different gestational age.Methods Seventy-five cases of early newborns from January 2014 to January 2015 were selected.They were divided into 4 groups according to gestational age,15 cases in group A (28-30 weeks),18 cases in group B (＞30-33 weeks),17 cases in group C (＞33-37 weeks) and 25 cases in group D (＞ 37-40 weeks).All newborns were examined by the synchronous 12-lead ECG machine,and the changes in ECG time limit detection results,QRS amplitude and RV1 amplitude were compared among groups.Results (1) There was a significant difference in P-R intervals among group A [(0.090 ± 0.011) s],group B [(0.095 ± 0.012) s],group C [(0.098 ± 0.013) s] and group D [(0.105 ± 0.014) s] (F =7.458,P ＜ 0.05).The P-R intervals of group A,group B and group C were much shorter than those of group D (P ＜ 0.05);the comparison of QRS duration and QTc among groups had no statistical significance (F =1.626,1.569,all P ＞ 0.05).(2) In group A:QRS amplitude was:(4.430 ± 1.380) mV,RV1 amplitude:(0.850 ± 0.420) mV;in group B:QRS amplitude was:(4.800 ± 1.350) mV,RV1 amplitude:(1.012 ± 0.425) mV;in group C:QRS amplitude was:(5.200 ± 1.600) mV,RV1 amplitude:(1.210 ± 0.520) mV;in group D:QRS amplitude was:(5.800 ± 1.800) mV,RV1 amplitude:(1.509 ± 0.525) mV.There were significant differences in QRS and RV1 amplitude among 4 groups (F =7.002,16.870,all P ＜ 0.05).The QRS amplitude changes in group A and group C were far less than those in group D (P ＜ 0.05),the RV1 amplitude changes in group A,group B,and group C were far less than those in group D (P ＜ 0.05),and there was no difference between among other groups (all P ＞ 0.05).Conclusions There are correlations between the electrocardiographic parameters of right heart and the gestational age of newborn infants.These parameters,including the P-R intervals,the amplitude of QRS and RV1,increase with the gestational age.

ObjectiveTo prove that grain-sized moxibustion plus Western medication is effective in preventing the attack of chronic obstructive pulmonary disease (COPD), by adopting the grain-sized moxibustion to treat patients under acute attack of COPD due to accumulation of phlegm and stasis.MethodForty patients under acute attack of COPD due to phlegm and stasis were randomized into two groups. The control group was intervened by antibiotics plus Mucosolvan and nebulization (Mucosolvan+Pulmicort+Ipratropium Bromide Solution). The treatment group was intervened by grain-sized moxibustion in addition to the above treatments.Two weeks later, the two groups were compared in the use of antibiotics, C-reactive protein, and therapeutic efficacy.ResultThe use of antibiotics and the content of C-reactive protein in the treatment group were less than that in the control group.ConclusionFor patients under the acute attack of COPD due to accumulation of phlegm and stasis, grain-sized moxibustion can shorten the time of using antibiotics and descend the content of C-reactive protein by modulating inflammation.

Objective:To evaluate the cost-effectiveness of levofloxacin and gatifoxacin in the treatment of lower respiratory tract infections.Method:The clinical data of levofloxacin and gatifoxacin in the treatment of lower respiratory tract infections were collected with the evidence-based medicine method and were evaluated with pharmacoeconomic cost-effectiveness analysis.Result:The cure rates of two drugs were 64.29%(57.70%,70.88%),and 81.43%(70.05%, 92.81%)and the cost-effectiveness ratios were 1.90 and 5.79 respectively.The?C/?E was 20.37.Conclusion:The cost-effectiveness analysis indicated that the cost-effectivenss ratio of levofloxacin is superior to that of gatifoxacin though the cure efficacy of gatifoxacin for lower respiratory tract infections is better.