Objective To establish the quality standard for Yuyuan Mingmu Granula. Methods Radix Et Rhizoma Notoginseng,Fructus Schisanrae Chinesis,Flos Scophorae and Fructus Forsythiae were identified by TLC. The content of loganin was determined by HPLC. Results Under the selected conditions,clear and specific spots were obtained. For content determination,the linear range of loganin was 0.084 ?g～0.840 ?g,r=0.999 9,the average recovery was 98.5 %(n=6)and RSD was 1.29 %. ConcLusion The method is proved to be simple and specialized with a good reproductivity and can be used to control the quality of Yuyuan Mingmu Granula.

OBJECTIVE:To investigate clinical efficacy and safety of levetiracetam add-on therapy in the treatment of elderly epileptic patients. METHODS:Totally 88 elderly epileptic patients in Chongqing Yunyang County Hospital of TCM during Jan. 2014-Jan. 2016 were divided into observation group and control group according to random number table,with 44 cases in each group. Control group was given routine antiepileptic therapy of carbamazepine+phenobarbital;observation group was additionally given Levetiracetam tablet with initial dose of 0.25g,increasing to 0.5 g according to disease condition,bid,on the basis of con-trol group. Treatment courses of 2 groups lasted for 6 months. Clinical efficacies,GCS score,Barthel index score,MoCA score and the occurrence of ADR were observed in 2 groups. RESULTS:Total response rate,control rate and MoCA score of observation group were significantly higher than those of control group,with statistical significance(P<0.05). GCS and Barthel index score of 2 group after treatment were significantly higher than before treatment,and those 2 scores of observation group were significantly higher than those of control group,with statistical significance (P<0.05). No obvious ADR was found in 2 groups. CONCLU-SIONS:Levetiracetam add-on therapy is better than routine therapy plan in the treatment of elderly epilepsy,and significantly re-duce coma degree,increase daily living ability and cognitive function with good safety.

Epilepsy ; diagnosis ; drug therapy ; surgery ; Humans ; Magnetoencephalography ; Positron-Emission Tomography ; Stereotaxic Techniques ; Surgery, Computer-Assisted ; methods ; Treatment Failure

ObjectiveTo investigate and analyze the factors affecting the quality of life of patients with gastric cancer after surgery. Methods120 cases of gastric cancer patients undergoing resection of gastric cancer from March 2009 to March 2010 in our hospital were chosen as the research object.100 cases of non-cancer patients with similar general information and without factors affecting quality of life at the same period were chosen as the control group.Quality of Life Questionnaire of Stomach 22 (QLQ-STO22) were used to investigated the quality of life of patients in the two groups.The factors affecting the quality of life for patients with gastric cancer were analyzed.Countermeasures to increase the quality of life of cancer patients were explored according to factors affecting the quality of life. ResultsThe study showed that quality of life of gastric cancer patients was significantly lower than the control group.The differences were significant.Multiple linear regression analysis showed that gender,age,personality,education degree,family economic status,cancer disease were the main factors affecting their quality of life. ConclusionsIn clinical care of patients with gastric cancer,the medical staff should take appropriate psychological care and health education based on individual circumstances of patients,try to eliminate the adverse fractors of patients in psychology,cognition and thought in order to enhance the quality of life of patients after surgery.

Objective:To improve the quality standard for Mahuangzhisou capsules. Methods:A TLC method was used to identi-fy five components including Asari Radix Et Rhizoma, Schisandrae Chinensis Fructus, Fritillariae Cirrhosae Bulbus, Platycodonis Radix and Citri Exocarpium Rubrum in the capsules. An HPLC method was used to determine the content of Citri Exocarpium Rubrum. Re-sults:The TLC identification method for Asari Radix Et Rhizoma, Schisandrae Chinensis Fructus, Fritillariae Cirrhosae Bulbus, Platyc-odonis Radix and Citri Exocarpium Rubrum was established without any interference. The HPLC method for the determination of Citri Exocarpium Rubrum was established, and the linear concentration of hesperidin was 3.03-302.80 μg·ml-1(r=0.999 9), and the average recovery was 99. 80%(RSD=0. 49%,n=9). Conclusion:The new quality standard is simple and accurate, which can effec-tively control the quality of the preparation.

Adolescent ; Adult ; Aged ; Capsules ; Drugs, Chinese Herbal ; therapeutic use ; Female ; Hepatitis B, Chronic ; complications ; drug therapy ; Hepatitis C, Chronic ; complications ; drug therapy ; Humans ; Liver Cirrhosis ; drug therapy ; etiology ; Male ; Middle Aged ; Phytotherapy

Diabetes mellitus has become one of the diseases which threaten the heath of human being in the 21st century.A goal of research in diabetes is to find a way to increase the number of functional insulin-producing cells. Islet transplantation has been considered to be the most effective approach to cure type Ⅰ and part of type Ⅱ diabetes mellitus.This approach, however, is severely limited by an inadequate supply of donor islets available for transplantation.Moreover, recent progress of stem cells research has shown that stem cells may act as a new source of islet transplantation in diabetes mellitus treatment. Recent evidence indicates that Glucagon-Like PeptideⅠ(GLP-1) plays a very important role in targeted differentiation of stem cells into Insulin-Producing Cells and pancreatic development. GLP-1 is an intestine-derived insulinotropic hormone that stimulates glucose dependent insulin production and secretion. GLP-1 can induce differentiation of stem cells into insulin-producing cells, which is achieved by up regulation of PDX-1 expression.PDX-1 is a transcription factor critical for pancreatic development and endocrine cell neogenesis and a marker for pancreatic stem cells. These new findings suggest an approach to create Insulin-Producing cells in vitro by expanding stem/progenitor cells and then to convert them into Insulin-Producing cells by treatment with GLP-1. Thus GLP-1 may be a means by which to create Insulin-Producing cells ex vivo for transplantation into patients with insulinopenic type Ⅰ diabetes and severe forms of type Ⅱ diabetes. This article reviews recent progress about GLP-1 and targeted differentiation of stem cells induced by GLP-1.

Adult ; Humans ; Male ; Maxillary Sinusitis ; complications ; Nasal Polyps ; complications

Objective To investigate the clinical significance of the combination detection of blood lactic acid,B-type brain natri-uretic peptide(BNP)and homocysteine(Hcy)in elderly acute cerebral infarction.Methods The arterial and venous blood during a-cute onset stage,at 24,48,72 h after thrombolysis and at 12 h after fasting in 85 cases of acute cerebral infarction was collected for detecting blood lactic acid,BNP and Hcy,performing the dynamic monitoring analysis and the comparative observation with the healthy control group.Results The blood lactic acid,BNP and Hcy levels in the acute onset stage group and the recovery group were significantly increased compared with the healthy control group(P <0.05).The blood lactic acid,BNP and Hcy levels during the onset stage in the acute cerebral infarction group were(6.47 ±3.92)mmol/L,(100.52 ±48.96 )pg/mL and(48.96 ±15.13 )μmol/L respectively,which were significantly higher than those at 48,72 h of postoperative recovery,the differences between them were statistically significant(P <0.05).The blood lactic acid,BNP and Hcy levels during postoperative convalescence in the cere-bral infarction group were gradually decreased and declined to the minimal level until postoperative 72 h,which were(2.16±1.83) mmol/L,(33.61±10.42)pg/mL and(18.87±8.27)μmol/L respectively.Conclusion Blood lactic acid,BNP and Hcy are closely related with the occurrence and development of cerebral infarction,the joint detection of these three indicators provide a reliable ba-sis for the early diagnosis of elderly acute cerebral infarction.The active and effective treatment on the patient should be timely a-dopted and the dynamic monitoring should be performed in order to correctly assess the prognosis.

Objective To explore the clinical characteristics, treatment and outcomes of patients with panniculitis. Methods Clinical data of patients with panniculitis admitted to our hospital were analyzed and followed up. The disease was classified into two sub-types: cutaneous type and systemic type. The clinical profile and treatment as well as the outcomes were compared. Results The mean follow up time of 61 in-patients with panniculitis was 49.2 months (range: 2～216 months). Remission could be achieved in 17 patients, recurrent episodes happened in 26 patients. Eighteen patients turued out to be diffuse connective tissue disease (CTD), hematological disorders, malignant tumors and tuberculosis during follow-up. The age at sympton onset was 33±17 years old in 43 patients with primarily panniculitis which eutaneoua sub-tye was 12 patients and systemic sub-tye was 31 patients. The male: female ratio was 1:15. Patients with systemic sub-type were associated with liver (25 patients), spleen (23 patients), respiratory system (11 patients), kidney (12 patients), and circulatory (3 patients) system involvement. Nine patients with systemic sub-type presen-ted white blood cell decrease while none of in the cutaneous sub-type. The difference was significant (P=0.044). Biopsy of the lesions had shown nuclear dust in 16.3% of primarily panniculitis patients. Conclusion Pannieulitis can associate with systemic rheumatic diseases, malignant tumors, hematological disorders and tuberculosis. The main systemic involvements with systemic sub-type are liver and spleen, and may have whiteblood cell decreasing. Some patients could achieve remission when treated with corticosteroids and/or immunosuppressive drugs. However,the majority of patients will have recurrences when corticosteroids is tapered.