Objective To investigate the impacts of Xuebijing injection on systemic inflammatory response and immune function of patients with acute exacerbation of severe chronic obstructive pulmonary disease (AECOPD). Methods A prospective randomized controlled trial (RCT) was conducted. Forty patients with severe AECOPD were divided into control group and Xuebijing group in accordance with the random number table, each group 20 cases. Both groups were treated by routine conventional basic therapy of severe AECOPD including anti-infection, phlegm-expelling formula, bronchodilators and mechanical ventilation, etc, while in Xuebijing group, intravenous drip of Xuebijing (100 mg, twice a day for 5 days) was additionally used. The changes of data of arterial blood gas analysis, blood routine examination, C-reactive protein (CRP), procalcitonin (PCT), immune function, and acute physiology and chronic health evaluation system Ⅱ (APACHE Ⅱ) score before and after therapy were observed and compared between the two groups. The length of stay in hospital, duration of mechanical ventilation, and prognosis were also compared between the two groups. Besides, according to the difference in APACHE Ⅱ score, all the patients were divided into APACHEⅡscore≥15 score group (18 cases) and APACHEⅡscore<15 score group (22 cases), and the immune function were compared between the two groups. Results ①The immune function was descended and disordered in patients with severe AECOPD. Compared with the < 15 score group, the expressions of CD45+, CD3+, CD4+, CD4+/CD8+ ratio, B-lymphocyte, natural killer cell (NK cell) in ≥ 15 score group were significantly lowered [CD45+(×106/L):663.92±100.61 vs. 1 289.92±169.38, CD3+(×106/L):342.05±108.93 vs. 882.37±172.56, CD4+(×106/L):205.96±63.97 vs. 486.24±108.64, CD4+/CD8+ratio:0.76±0.49 vs. 1.32±0.57, B-lymphocyte (×106/L):124.77±32.72 vs. 166.06±48.02, NK cells (×106/L): 186.47±39.57 vs. 243.51±44.72, all P < 0.05]. There was no statistically significant difference in the expression of CD8+ between the ≥ 15 score group and < 15 score group (P > 0.05). ② Compared with those before therapy, the pH value, oxygenation index, arterial partial pressure of carbon dioxide (PaCO2), white blood cell count (WBC), CRP, PCT were significantly improved after therapy in both control and Xuebijing groups. Compared with those in the control group, WBC, CRP, PCT were significantly lowered in Xuebijing group [WBC (×109/L): 10.29±3.83 vs. 12.69±3.42, CRP (mg/L): 9.06±4.19 vs. 15.26±4.22, PCT (ng/L): 0.18±0.21 vs. 0.42±0.24, all P < 0.05]. There were no statistically significant differences in pH value, oxygenation index and PaCO2 between two groups (all P>0.05). The degrees of improvement of CD45+, CD3+, CD4+, CD8+ and CD4+/CD8+ ratio were more remarkable in Xuebijing group after treatment than those in control group [CD45+ (×106/L): 1 079.38±153.86 vs. 1 015.63±157.11, CD3+ (×106/L): 652.05±100.05 vs. 596.81±106.85, CD4+ (×106/L): 358.92±67.53 vs. 329.99±72.61, CD8+ (×106/L): 205.73±35.19 vs. 230.41±39.74, CD4+/CD8+ratio: 2.16±0.63 vs. 1.52±0.54, all P < 0.05]. The B-lymphocyte and NK cell before treatment and after treatment showed no statistical significant differences between the two groups (all P > 0.05). Compared with the control group, the duration of mechanical ventilation (hours: 56.25±22.87 vs. 69.45±26.59) and the length of stay in hospital (days: 11.00±0.74 vs. 14.00±2.06) were shortened, and APACHE Ⅱ score was significantly lowered in Xuebijing group (8.21±2.97 vs. 12.08±3.12, P < 0.05). The numbers of multiple organ failure and dead patients in Xuebijing group were less than those of control group, but no statistical significant differences were found (both P > 0.05). Conclusion Xuebijing injection for treatment of patients with severe AECOPD can ameliorate inflammatory response, improve immune function, shorten the duration of mechanical ventilation and the length of stay in hospital, and decrease the risk of death.

Objective To understand the clinical distribution and drug resistance situation of112 strains of Acinetobacter Bau-mannii isolated from the patients′sputum samples in cerebral surgery ICU in order to provide the basis for the rational use of anti-bacterial drugs in clinical therapy.Methods 112 strains of Acinetobacter Baumannii were performed the retrospective analysis.The VITEK2-Compact automatic microbiological analyzer was adopted to conduct the bacterial identification and the drug susceptibility test and the K-B method was combined as the supplement control.The Whonet 5.6 software was used for conducting the statistical analysis.Results Among 112 strains of Acinetobacter baumannii,75 strains(67.0%)were multi-drug resistant,8 strains(7.1%) were pan-resistant.The antimicrobial susceptibility tests showed that the resistant rates of Acinetobacter baumannii to mezlocillin, piperacillin and nitrofurantoin reached up to 100%.Acinetobacter Baumannii had the lower resistant rate to polymyxin B (2.7%), the resistant rates to minomycin and ceperazone/sulbactam were 4.5% and 10.7% respectively.Conclusion The drug resistance phenomena of Acinetobacter Baumannii in the cerebral surgery department ICU is serious.Minomycin,polymyxin B and ceperazone/sulbactam have the better antibacterial activities to clinically isolated Acinetobacter Baumannii and may be the alternative drugs for therapy.Clinic should strengthen the monitoring and rationally use the antibacterial drugs.

Cervical cancer is one of the commonly malignant neoplasms for women in our country.It's etiology has known by us through hard working.Cervical cancer is the result of many factors:infection with oncogenic human papillomavirus(HPV)types is the necessary cause of cervical cancer,but not the sufficient cause,and other exogenous and endogenous factors are in conjunction with HPV,such as herpes simplex virusII and chlamydia trachomatis infection,activation of oncogene and inactivation of anti-oncogene,sexual behavior,parity,oral contraceptive(OC)use,smoking and So on.

Response Evaluation Criteria In Solid Tumors (RECIST) and WHO Criteria are the most in portant ones.There are some differences between them,in one word,RECIST is better than WHO Criteria when implemented in clinic.However,there are some shortcomings in RECIST.Improvement is needed to make the criteria more and more Derfect and scientific.

Rotavirus is the most common pathogens of diarrheal diseases in children. Rotavirus infection lead to not only gastrointestinal symptoms but also a variety of extraintesu'nal manifestations. The pathogenesis of RV diarrhea and especially RV viremia is related to multiple factors. Rotavirus infectious diarrhea is related to the damaged cell intercellular connections,the non-structural protein 4, heat shock protein hsc70 and other factors. Pathogenesis of RV viremia may be related to the secretion of inflammatory mediators in vivo and expression of cytokines after RV infection.

Objective To know the effects of comfort nursing cares on strok patients'limb function rehabilitation. Methods Divided 100 patients with cerebral apoplexy into the experimental group and the control group randomly,there were 50 cases in each group. Routine nursing cares was used in the control group,while the comfort nursing cares was used in the experimental group in addition. Evalued the ability of daily living,move function and the incidence rate of complications between the two groups by Barthe and Fugl-Meyer after 3-month intervention. Results Before the intervention,there was no significant difference between the two groups about values of Barthe and Fugl-Meyer,while after the intervention,the difference was significant. The incidence rate of complication in the control group was significant higher than that in the experimental group. Conclusions Comfort nursing cares can effective promote the rehabilitation of limb function in strok patients with few complications.

Objective To explore the effect of health education with integrated traditional Chinese and western medicine on patients with cardio-cerebrovascular disease, in order to reach the aim of preven-tion and treatment of cardio-cerebrovascular disease, promotion of early rehabilitation and maintenance of health in them. Methods 80 cases of patients with cardio-cerebrovascular disease were randomized into the control group and the intervention group with 40 cases in each group, Both groups received routine treatment, the intervention group received health education based upon routine treatment. Questionnaires were formulated to investigate change of bad habit and primary disease,return visit and incidence of compli-cation one year after intervention, X2 test was adopted. Results The change rate of bad habit was higher, the change rate of primary disease,rate of return visit and incidence rate of complication were lower in the intervention group compared with those in the control group. Conclusions Health education with inte-grated traditional Chinese and western medicine for patients with cardio-cerebrovascular disease can in-crease their cognition of self- care,life quality and health level which is worthy of wide application in clinic and community.

To explore the of occupational therapy for the cerebral palsied children was introduced. The assessment areas of occupational therapy and evaluational instruments commonly used. The last part gives the concrete treatment methods that occupational therapy usually adopts in practice, specially in the fields of training and developing the grass motor skills of the upper limbs, the fine motor skills of the hands and ADL skills of the children with cerebral palsy were also stated.

Autistic disorder is a severe neuropsychiatric disease and abnormal development in early childhood.The main clinical manifestations of autistic disorder are social interaction,language and behavior barriers.Currently,the incidence trend has showed increased year by year,the pathogenesis of autism has also been considerable development.This paper reviews the latest developments in autism,make excitatory/inhibitory neurotransmitter imbalances,nicotinamide metabolism and HPA axis dysfunction is the main pathogenesis of autism.

The paper introduces reference work in the new age from its modes, contents, characteristics and developing strategies,including establishing characteristic resources, improving quality of librarians, carrying out network consultant and information navigation, establishing collaborative digital reference, in order to provide reference for primary hospital libraries.