Objective To investigate the impacts of Xuebijing injection on systemic inflammatory response and immune function of patients with acute exacerbation of severe chronic obstructive pulmonary disease (AECOPD). Methods A prospective randomized controlled trial (RCT) was conducted. Forty patients with severe AECOPD were divided into control group and Xuebijing group in accordance with the random number table, each group 20 cases. Both groups were treated by routine conventional basic therapy of severe AECOPD including anti-infection, phlegm-expelling formula, bronchodilators and mechanical ventilation, etc, while in Xuebijing group, intravenous drip of Xuebijing (100 mg, twice a day for 5 days) was additionally used. The changes of data of arterial blood gas analysis, blood routine examination, C-reactive protein (CRP), procalcitonin (PCT), immune function, and acute physiology and chronic health evaluation system Ⅱ (APACHE Ⅱ) score before and after therapy were observed and compared between the two groups. The length of stay in hospital, duration of mechanical ventilation, and prognosis were also compared between the two groups. Besides, according to the difference in APACHE Ⅱ score, all the patients were divided into APACHEⅡscore≥15 score group (18 cases) and APACHEⅡscore<15 score group (22 cases), and the immune function were compared between the two groups. Results ①The immune function was descended and disordered in patients with severe AECOPD. Compared with the < 15 score group, the expressions of CD45+, CD3+, CD4+, CD4+/CD8+ ratio, B-lymphocyte, natural killer cell (NK cell) in ≥ 15 score group were significantly lowered [CD45+(×106/L):663.92±100.61 vs. 1 289.92±169.38, CD3+(×106/L):342.05±108.93 vs. 882.37±172.56, CD4+(×106/L):205.96±63.97 vs. 486.24±108.64, CD4+/CD8+ratio:0.76±0.49 vs. 1.32±0.57, B-lymphocyte (×106/L):124.77±32.72 vs. 166.06±48.02, NK cells (×106/L): 186.47±39.57 vs. 243.51±44.72, all P < 0.05]. There was no statistically significant difference in the expression of CD8+ between the ≥ 15 score group and < 15 score group (P > 0.05). ② Compared with those before therapy, the pH value, oxygenation index, arterial partial pressure of carbon dioxide (PaCO2), white blood cell count (WBC), CRP, PCT were significantly improved after therapy in both control and Xuebijing groups. Compared with those in the control group, WBC, CRP, PCT were significantly lowered in Xuebijing group [WBC (×109/L): 10.29±3.83 vs. 12.69±3.42, CRP (mg/L): 9.06±4.19 vs. 15.26±4.22, PCT (ng/L): 0.18±0.21 vs. 0.42±0.24, all P < 0.05]. There were no statistically significant differences in pH value, oxygenation index and PaCO2 between two groups (all P>0.05). The degrees of improvement of CD45+, CD3+, CD4+, CD8+ and CD4+/CD8+ ratio were more remarkable in Xuebijing group after treatment than those in control group [CD45+ (×106/L): 1 079.38±153.86 vs. 1 015.63±157.11, CD3+ (×106/L): 652.05±100.05 vs. 596.81±106.85, CD4+ (×106/L): 358.92±67.53 vs. 329.99±72.61, CD8+ (×106/L): 205.73±35.19 vs. 230.41±39.74, CD4+/CD8+ratio: 2.16±0.63 vs. 1.52±0.54, all P < 0.05]. The B-lymphocyte and NK cell before treatment and after treatment showed no statistical significant differences between the two groups (all P > 0.05). Compared with the control group, the duration of mechanical ventilation (hours: 56.25±22.87 vs. 69.45±26.59) and the length of stay in hospital (days: 11.00±0.74 vs. 14.00±2.06) were shortened, and APACHE Ⅱ score was significantly lowered in Xuebijing group (8.21±2.97 vs. 12.08±3.12, P < 0.05). The numbers of multiple organ failure and dead patients in Xuebijing group were less than those of control group, but no statistical significant differences were found (both P > 0.05). Conclusion Xuebijing injection for treatment of patients with severe AECOPD can ameliorate inflammatory response, improve immune function, shorten the duration of mechanical ventilation and the length of stay in hospital, and decrease the risk of death.

Objective To understand the clinical distribution and drug resistance situation of112 strains of Acinetobacter Bau-mannii isolated from the patients′sputum samples in cerebral surgery ICU in order to provide the basis for the rational use of anti-bacterial drugs in clinical therapy.Methods 112 strains of Acinetobacter Baumannii were performed the retrospective analysis.The VITEK2-Compact automatic microbiological analyzer was adopted to conduct the bacterial identification and the drug susceptibility test and the K-B method was combined as the supplement control.The Whonet 5.6 software was used for conducting the statistical analysis.Results Among 112 strains of Acinetobacter baumannii,75 strains(67.0%)were multi-drug resistant,8 strains(7.1%) were pan-resistant.The antimicrobial susceptibility tests showed that the resistant rates of Acinetobacter baumannii to mezlocillin, piperacillin and nitrofurantoin reached up to 100%.Acinetobacter Baumannii had the lower resistant rate to polymyxin B (2.7%), the resistant rates to minomycin and ceperazone/sulbactam were 4.5% and 10.7% respectively.Conclusion The drug resistance phenomena of Acinetobacter Baumannii in the cerebral surgery department ICU is serious.Minomycin,polymyxin B and ceperazone/sulbactam have the better antibacterial activities to clinically isolated Acinetobacter Baumannii and may be the alternative drugs for therapy.Clinic should strengthen the monitoring and rationally use the antibacterial drugs.

Objective:To discuss the curative effect of lacidophilin vaginal capsules combined with loop electrosurgical excisional procedure ( LEEP) in the treatment of cervical erosion with chronic cervicitis. Methods:Totally 72 cases of patients with cervical ero-sion with chronic cervicitis were selected and divided into the observation group and the control group at random. The patients in the two groups were given routine LEEP with the application of antibiotics to prevent infection for 1 week. The patients in the observation group were additionally given lacidophilin vaginal capsules, placed in the vagina after the operation, one capsule per time at every night for 14 days. The vaginal fluid time and vaginal bleeding time in the two groups were observed. The clinical curative effect and adverse drug reactions ( ADRs) after 8 weeks of the operation were studied and evaluated again. Results: The vaginal bleeding amount and bleeding time in the observation group after the operation was less or shorter than that in the control group (P<0. 05). According to the further consultation after 8 weeks of the operation, the total clinical efficiency in the observation group was 94. 44%, which was ob-viously higher than that in the control group(75. 00%,P<0. 05). There was no obvious ADR appeared in the two groups during the treatment. Conclusion:Lacidophilin vaginal capsules combined with LEEP has reliable curative effect on cervical erosion with chronic cervicitis, which can obviously shorten the wound healing time and decrease the vaginal bleeding amount and time with high security.

Objective:To study the speech articulation and the consonant /r/acoustic features of articulation disorders caused by velopharyngeal insufficiency.Methods:According to “Uyghur speech articulation test scale”and the classification method used in Uyghur articulation disorders the articulation and characterization of consonant /r/of 31 cases with velopharyngeal insufficiency were examined,scored and classified.Results:The cases of mild(-x =81),moderate(-x =51)and severe(-x =21)voice disorder in the 31 patients were 9,12 and 10 respectively.Among the 3 groups,CD,CA,F1,F3 and F4 were different(P <0.05),F2 was not (P>0.05).Conclusion:“Uyghur speech articulation test scale”and speech articulation classification standard have certain clinical value in of the study of Uyghur articulation disorders.There are differences in pathological consonant acoustic parameters of consonant/r/between and patients with velopharyngeal insufficiency and the subjects with normal speech.

Objective To explore the changes and clinical significance of the serum concentrations of serum IL‐1β,IL‐8 and TNF‐αin patients with acute cerebral infarction .Methods Serum concentrations of IL‐1β,IL‐8 and TNF‐αfrom 187 patients with acute cerebral infarction and 150 healthy donors were determined by enzyme linked immunosorbent assay (ELISA) .Results The serum levels of IL‐1β,IL‐8 and TNF‐αwere markedly higher in the 3 different infarct size subgroups than in the control group ,and the 3 indexes were statistically increased with increasing infarct size .Conclusion Serum levels of IL‐1β,IL‐8 and TNF‐αincreased markedly in patients with acute cerebral infarction ,which was closely related to infarct size ,and could be used as the indicators for severity assessment ,therapy monitoring and prognosis judgement in acute cerebral infarction patients .

Tai Chi Chuanis a traditional Chinese method of regimen and health care, which has attracted wide attention from countries in the world. This article was aimed to analyze the current situation and hot spots about Tai Chi Chuan for future research. A total of 1349 articles were retrieved from Web of Science from 1981 to 2013. CiteSpace was used to map knowledge domain of 1349 articles in order to explore the current situation and hot spots aboutTai Chi Chuan internationally. The results showed that the research onTai Chi Chuan showed a rising trend. The main research regions were in the United States and China. The research fields were extended from medicine and sport science to psychology, engineering and computer science. The hot spots were focused on physical control, psychology and cardiovascular diseases. It was concluded thatTai Chi Chuan was a method benefit to both physical and mental health. The focus of future Tai Chi Chuan research was on basic theory, action mechanism and strict evidences.

Objective To investigate the clinical efficacy and safety of electroacupuncture plus pelvic floor muscle training in treating postoperative retention of urine. Method Patients were allocated, according to admission date, to a treatment group of 33 cases and a control group of 34 cases. The treatment group received electroacupuncture at point Ciliao (BL32) plus pelvic floor muscle training and the control group, intermittent catheterization. The overall health degree was assessed using the therapeutic effect evaluation, first voiding time, residual urine volume and the number of urinary tract infection patients before and after treatment. Result The improvement rate was higher in the treatment group than in the control group and there was a statistically significant difference (P<0.05). Voiding recovery time was shorter and residual urine volume was smaller in the treatment group and there were statistically significant differences compared with the control group (P<0.01). Conclusion Electroacupuncture plus pelvic floor muscle training can effectively treat postoperative retention of urine. It is a safe and effective therapeutic method.

Objective To investigate the iodine nutritional status of pregnant women during different pregnancy of Zhuhai area in 2013 .Methods Adoption iodine arsenic cerium catalytic reaction principle ,Hitachi 7600‐020 automatic biochemical analyzer was used to detect the concentration of urinary iodine .Results To detect the urine iodine of 2 214 cases of pregnant women whose con‐form the conditions ,iodine deficiency were found up to 1 421 cases ,accounting for 64 .19% ;Iodine qualifiers were found up to 767 cases ,accounting for 34 .64% ;Excess iodine people were found up to 26 cases ,accounting for 1 .17% .Conclusion The iodine defi‐ciency situation is more severe of pregnant women in Zhuhai area ,we should intensify propaganda it and it should be included in the routine monitoring of prevention .When a pregnant woman was abnormal urine iodine level in monitoring ,we should give the iodine nutrition health prescription guidance to them ,so as to continuously improve the qualification rate of pregnant women urine iodine level .

Outdoor particulate matter can affect human health seriously,and children are possibly susceptible to the effects of particulate matter because of the characteristics of the growth and development.Particulate matter is categorized into total suspended,inhalable,fine,and ultrafine fractions on the basis of its aerodynamic diameter.To explore the short-term effects of particulate matter on pediatric asthma,this article reviews the components and property of particulate matter,the possible mechanisms and the epidemiological studies of particulate matter on children with asthma.

Objective Hemapoietic stem cell (HSC) is a kind of pluripotent cell which can differentiate into different kinds of cells,including blood cells and immune cells.Hemapoietic stem cell transplantation(HSCT) is to destory abnormal bone marrow hematopoietic cells,and imbed healthy stem cells to reconstruct hematopoiesis and immune system,and it is an effective therapy for the treatment of hematopoietic malignances,genetic and metabolic disease,autoimmune disease and solid tumor.At present,it has been widely used to treat the patients with hematologial malignant tumors,such as lymphoma and leukemia.Clinical investigation showed that patients with leukemia and psoriasis after HSCT,both leukemia and psoriasis were cured.In this review,the immunopathogenesis of psoriasis,the possible mechanism of psoriasis associated with leukemia,the immunopathogenesis of HSCT and the theory basis of treating psoriasis and the application of HSCT in the treatment of psoriasis with leukemia were comprehensively discussed.