Autistic disorder is a severe neuropsychiatric disease and abnormal development in early childhood.The main clinical manifestations of autistic disorder are social interaction,language and behavior barriers.Currently,the incidence trend has showed increased year by year,the pathogenesis of autism has also been considerable development.This paper reviews the latest developments in autism,make excitatory/inhibitory neurotransmitter imbalances,nicotinamide metabolism and HPA axis dysfunction is the main pathogenesis of autism.

Objective:To evaluate the roles of imbalance between peripheral blood T helper17(Th17) cells and CD4+CD25+regulatory T(Treg) cells in the pathogenesis of Anaphylactoid purpura(AP).Methods: Peripheral blood samples were obtained from fifty-two patients with AP and thirty age-and sex-matched healthy controls.The percentage of Th17 cells and Treg cells in peripheral blood were detected with Flow cytometry.Furthermore,the serum level of IL-6,IL-17,IL-22 and IL-23 and transforming growth factor (TGF)-βand IL-10 were detected with the use of enzyme linked immunosorbent assay(ELISA).Results: In comparison with the controls,the AP children showed a higher percentage of Th17 cells and an increased serum level of IL-6,IL-17,IL-22 and IL-23(P<0.05),but the percentage of Treg cells and the serum level of TGF-βand IL-10 were significantly lower in AP group(P<0.05).Con-clusion:AP children experience a change in the percentage of peripheral blood T helper17 cells and CD4+CD25+regulatory T cells in peripheral blood.The imbalance between the Th17 cells and Treg cells in peripheral blood may contribute to the development of Ana-phylactoid purpura.

Medical imaging plays an important role in modern medical diagnosis. Wavelet transformation is widely applied in medical imaging processing, including the fields of edge-detection, noise-reducing, image-enhancement, image-compression and image-integration. The theories and application of Wavelet transformation were systematically reviewed in this paper.

The results of 44 patients with medullobastoma treated by postoperative radiation are reported. The overall 1, 3 and 5 year survival rates were 81.80%, 31.80% and 16.80% respectively.The authors analysed the factors resulting in the lower survival rates and discussed the approach to improve the resuts of postoperative radiation

Objective:To identify the human hepatocarcinoma cell line with the highest reactivity to hALR and to construct the phage-displayed library with its cDNA as the basis of the selection for special protein binding hALR from this library.Methods:The reactivity to hALR of HepG2,7701 and QGY was compared by 3?H-TdR methods in vitro.The mRNA of QGY with the highest reactivity to hALR was isolated with PloyATtract System 1000 kit.The phage-displayed library with cDNA fragments of QGY was constructed withT7Select10-30rient Express cDNA Cloning System and Random Primer kit.The quality of this library was evaluated by phage titer assay and PCR.Results:hALR could stimulate the proliferation of QGY,HepG2,and 7701 in dose-dependent way in vitro,but QGY showed the highest reactivity to hALR.The phage-displayed library with cDNA of QGY was successfully constructed and contained approximate 2?107 primary recombinants.It was indicated by PCR that the size of the cDNA inserts was from 0.2 to 2kb,the average 0.6kb.Thorough information about mRNA of QGY cells could be soundly represented by this library.Conclusion:The results show that QGY had the highest reactivity to the hALR among three strains detected.The high quality phage-displayed library is successfully constructed with cDNA of QGY.

Objective To investigate the changes of arterial blood flow in pregnant women with severe preeclampsia(SPE) and fetuses and the effect of magnesium sulfate on it.Methods One hundred and seventy-four SPE pregnant women in our hospital from January 2013 to January 2015 were selected as the observation group and 174 normal pregnant women as the control group.The observation group was given the magnesium sulfate treatment for 2 d.The arterial blood flow changes of middle cerebral artery,uterine artery,uterine spiral artery,umbilical artery,fetal middle cerebral artery before and after treatment in the observation group were observed.And maternal blood pressure,dizziness symptoms,no load test(NST) changes were also observed.Results The RI,PI and S/D values of pregnant women and fetal middle cerebral artery before and after treatment had no statistical differences between the control group and observation group(P＞0.05).The RI,PI and S/D values of uterine artery and uterine spiral artery before treatment in the observation group were significantly higher than those in the control group(P＜0.05);the RI,PI and S/D values of uterine artery and uterine spiral artery after treatment in the observation group were significantly lower than those before treatment(P＜0.05).The umbilical artery RI,PI and S/D values before treatment in the observation group were higher than those in the control group(P＜0.05);the PI and S/D values after treatment were lower than those before treatment,but difference was statistically significant(P＞0.05).The systolic pressure,diastolic pressure and mean arterial blood pressure after treatment in the observation group were decreased compared with treatment,and the proportion of dizziness was decreased compared with before treatment,but the difference was not statistically significant(P＞0.05),while the incidence rate of NST no response was significantly lower than that before treatment(P＜0.05).Conclusion The magnesium sulfate therapy can significantly improve the blood flow situation of uterine artery and uterine spiral artery in the patients with SPE and can improve fetal intrauterine reserve.

AIM:To analyze effect of the inside incision positions of clear corneal incisions of cataract on astigmatism after surgery was analysis using anterior segment optical coherence tomography.
METHODS: A total of 40 patients of 43 eyes of age-related cataract were chosen. All of them were done 2.8mm clear corneal incision and phacoemulsification with foldable intraocular lens implantation. Preoperative and postoperative 1wk, 1 and 3mo, the corrected visual acuity were examined. Postoperative 1wk, 1 and 3mo, the positions and lengths of the incisions were measured. Depending on the location of the incisions, the patients were divided into two groups. Group 1:the inside mouth of the incisions(22 patients of 23 eyes) were far from the corneal vertex central line> 3mm. Group 2: the inside mouth of the incisions ( 20 patients of 20 eyes ) were far from the corneal vertex central line ≤3mm.
RESULTS:One day before the surgery between Group 1 and Group 2 patients, there were no statistically significant difference(P>0. 05) in corrected visual acuity and corneal astigmatism. After the surgery, corrected visual acuity gradually increased, astigmatism and cut lengths gradually decreased. But, there were no statistically significant difference at 1wk, 1 and 3mo ( P<0.05).
CONCLUSION:The length of the inside mouth located within radius of the central cornea 3mm was rather longer than the length of the inside mouth located without radius of the central cornea 3mm. The SIA after surgery is greater, and postoperative visual acuity gained maybe less than the latter.

Mineral and bone disorder is one of the most common chronic complications of chronic kidney disease.The long-term metabolism disorder of bone,calcium and phosphate can cause not only bone disease,but also vascular/cardiac valve calcification and high morbidity of cardiac and/or vascular events.The treatment for these complications is mainly aimed to decrease high blood phosphate,maintain blood calcium and keep PTH within defined levels.

Rational processing for the alcoholic precipitation of saikosaponin from Chaihu was studied by the use of TLC densitometry. The concentration of alcohol for the optimum yield of saikosaponin A was found to be 60%.

Objective To explore CT character for acidophilic granuloma of skull.Methods 15 cases diagnosed clinic,pathology and CT were retrospectively analyzed and 4 of 15 cases had skull X-ray examination.Results Lipid,small bone piece,parenchyma lump and endocranium erosio for acidophilic granuloma of skull were showed clearly and accurately in CT.Conclusion Lipid is important CT character for acidophilic granuloma of skull,a reliable diagnosis can be made when combine CT with clinical information.