1.The use of the immunosuppressives for the patients with HCV after renal transplantation
Fukang SUN ; Jianyu LING ; Yu ZHU
Chinese Journal of Organ Transplantation 2000;21(3):151-152
Objective To study the use of immunosuppressives for the patients with virus C hepatitis(HCV)after renal transplantation.Methods Twenty-five cases of HCV-RNA(+)and 30 cases of HCV-RNA(-)as control group were analyzed.All patients were divided into the Aza group(n=12),MMF group(n=8)and MP(MMF+Pred)group(n=5).Results Eight casGS revealed abnormal liver function in the Aza group and 2 in MMF group.After stopping the use of CsA and Aza,the liver function all revealed good outcome in the MP group.During one week 30 cases of HCV-RNA(-)recovered due to the readjustment of the dosage of immunosupprexsives(CsA,Aza)in the control group.Conclnsions The therapy of MMF+CsA+Pred is necessary for the patients with HCV-RNA(+)and the function of the renal and liver can be stabilized by MMF.
2.Combined use of MMF with low dosage of cyclosporine A in renal transplantation
Jianyu LING ; Yu ZU ; Fukang SUN
Chinese Journal of Organ Transplantation 1998;19(3):175-176
In order to compare the therapeutics of combined use of MMF with low dose of cyclosporine A (CsA) in renal transplantation, 16 cases were randomly divided into 3 groups:MMF 2.0g group receiving MMF 2.0g per day, MMF 1.5g group receiving MMF 1.5g per day,and Aza group. All the patients in the 3 groups were given the low dosage of CsA and steroid.The results showed that no patients in MMF 2.0g group experienced acute rejection. One patient (20%) in MMF 1.5g group occurred twice acute rejections. In Aza group 3 out of 5 patients (60%) experienced acute rejections. Six months after transplantation, serum Cr level and the used dose of CsA in MMF 2.0g group was obviously lower than that of Aza group. It was concluded that the combined use of 2.0g MMF per day with low dosage of CsA and steroid was safe and efficacy for renal transplanted patients. The clinical results of MMF 2.0g group were superior to those of Aza group.
3.Median effective dose of esmolol for maintaining cardiovascular stability in elderly and non-elderly hypertensive patients during tracheal extubation
Huan GUO ; Ling YU ; Hongwei SUN
Chinese Journal of Postgraduates of Medicine 2016;39(6):561-564
Objective To study the optimal dose of esmolol for maintaining cardiovascular stability in patients with hypertension during tracheal extubation. Methods In post-anestheisa care unit, hypertensive patients after general anesthesia meeting the extubation criteria were included. Patients were divided into 2 groups according the age: group Ⅰ (>65 years old for the elderly hypertensive, 21 cases), and groupⅡ(≤65 years old for the non-elderly hypertensive, 22 cases). All the patients received esmolol bolus before sputum suction and tube extraction, and the tracheal extubation were extubated 2 minutes after esmolol bolus. The systolic blood pressure, diastolic blood pressure and heart rate were was recorded before tracheal extubation, 2 min after esmolol bolus, at the time of sputum suction extubation, 1 min after tracheal extubation, 3 min after tracheal extubation and 5 min after tracheal extubation. Esmolol dose was determined by the up and down method. Initial dose was 0.5 mg/kg, in accordance with the arithmetic dose (0.2 mg/kg) increasing or decreasing progressively. In negative results (the systolic blood pressure at extubation or 5 min after extubation ≥ 20% of the base, or the systolic blood pressure at sputum suction extubation>180 mmHg, 1 mmHg=0.133 kPa) esmolol dose increased progressively, and in positive results (the systolic blood pressure at extubation or 5 min after extubation<20%of the base) esmolol dose decreased progressively. When the crosspoint (from positive to negative result) reached 6, the study was terminated. Results The median effective doses of esmolol for maintaining cardiovascular stability in groupⅠand groupⅡwere (0.6 ± 0.1) and (0.8 ± 0.1) mg/kg. Conclusions Esmolol can maintain cardiovascular stability in patients with hypertension during tracheal extubation. Median effective dose decreases in older hypertensive patients.
4.Toxicity and telomerase activity of allicin combined with TFP chemotherapy for patients with advanced gastric carcinoma
Li SUN ; Sanyuan SUN ; Ling WEI ; Susheng CAO ; Dahai YU
Cancer Research and Clinic 2011;23(9):617-619
ObjectiveObserve the efficacy, toxicity and the effection of telomerase activity of allicin combined with paclitaxel plus cisplatin and 5-Fu(TFP)chemotherapy for patients with advanced gastric carcinoma.MethodsFifty-four patients with advanced gastric carcinoma were randomly divided into two groups. A group was treated with allicin and TFP, B group was only treated with TFP. The chemotherapy was paclitaxel (135 mg/m2, dl, 8) plus cisplatin (75 mg/m2, d2-4) followed by 5-Fu (500 mg/m2 d1-5). Allicin was used in 60 days(3 times every day,once 20 mg).Telomerase activity was performed by enzyme-linked immunosorbent assay. ResultsThe total efficiency rate was 40.7 % (11/27) in A group and 33.3 % (9/27) in B group.There was no statistical difference between the two groups(~ = 0.079,P =0.779).There was significant difference in nausea and vomit (P =0.043), and the incidence of A group was 77.8 % (21/27) which was lower than that of B group[92.6 %(25/27)].There was statistical difference in telomerase activity between the two groups(P =0.000).ConclusionAllicin could reduce the toxicity of chemotherapy and inhibit the telomerase activity in advanced gastric carcinoma.
5.Fibrosis-related differential expression and upstream mechanisms of beta-arrestin in the carbon tetrachloride-induced liver fibrosis mouse model.
Hui-ling SUN ; Yu-li GE ; Yong-ping CHEN
Chinese Journal of Hepatology 2013;21(10):773-775
Animals
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Arrestins
;
metabolism
;
Liver
;
pathology
;
Liver Cirrhosis, Experimental
;
metabolism
;
pathology
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Male
;
Mice
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Mice, Inbred ICR
;
beta-Arrestins
6.Molecular mechanisms of antithrombin gene mutations in 3 pedigrees with hereditary antithrombin deficiency.
Ling SUN ; Zi-qiang YU ; Chao-rong WANG
Chinese Journal of Hematology 2013;34(3):253-255
Adolescent
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Adult
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Antithrombin III Deficiency
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genetics
;
Antithrombins
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Female
;
Humans
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Male
;
Mutation
;
Pedigree
;
Phenotype
7.Efficacy of centrally fixed eyeball for assessment of depth of sevoflurane anesthesia in premature infants undergoing outpatient fundus examination
Ling YU ; Hongwei SUN ; Lan YAO ; Yi FENG ; Baxian YANG
Chinese Journal of Anesthesiology 2010;30(11):1290-1292
Objective To investigate the efficacy of centrally fixed eyeball for assessment of the depth of anesthesia in premature infants undergoing outpatient fundus examination. Methods Fifty eight premature infants undergoing examination of fundus of eyes were enrolled in this study. Their gestational age (from the first day of last menstruation period to birth) + after birth age (from birth to the day when examination of fundus of eyes was performed) = 44-64 weeks. The patients were randomly divided into 2 groups: Ⅰ group body movement (group M, n = 27) and Ⅱ group centrally fixed eyeball (group E, n = 31). Anesthesia was induced and maintained with isoflurane inhalation. The patients were breathing spontaneously. The eyelids were kept open with speculum after induction of anesthesia. The EC50 of sevoflurane concentration which could inhibit body movement or make eyeballs centrally fixed was determined by up-and-down sequential experiment. The initial isoflurane concentration was 3% in both groups. Each time the isoflurane concentration was increased/decreased by 0.5 %. 95 % confidence interval (CI) was calculated. The lowest SpO2, respiratory rate and coughing during maintenance of anesthesia were recorded. Results The EC50 of sevoflurane (95% CI) was 2.9% (2.2%-3.6%) in group M and 3.4%(2.6%-4.6%) in group E. Examination was successfully completed in all patients. No respiratory depression and coughing occurred during examination and no vomiting and coughing were observed during feeding at 1 h after recovery from anesthesia. No body movement occurred in 15 patients whose eyeballs were centrally fixed in group E. Conclusion Centrally fixed eyeball can be used as sign of appropriate depth of anesthesia for fundus examination in premature infants.
8.Penetration needling and interactive method for 30 cases of palpitation.
You-ling LIN ; Huan-yu SUN ; Lan-yuan LI
Chinese Acupuncture & Moxibustion 2014;34(10):977-978
Acupuncture Points
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Acupuncture Therapy
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Adult
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Aged
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Arrhythmias, Cardiac
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physiopathology
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therapy
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Female
;
Humans
;
Male
;
Middle Aged
9.Diagnosis of spinal nerves location combined with acupoints selection according to Hand-Sanyang meridian for 60 cases of cervical spondylosis of nerve root type.
Jin-niu LI ; Yu-ling LENG ; Ru SUN
Chinese Acupuncture & Moxibustion 2014;34(9):887-888
Acupuncture Points
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Adult
;
Female
;
Humans
;
Male
;
Meridians
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Radiculopathy
;
diagnosis
;
therapy
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Spondylosis
;
diagnosis
;
therapy
10.Therapeutic Effect of Radix Achyranthis Bidentatae Guiding Function on Diclofenac Sodium Induced Adjuvant Rats Arthritis
Yuequan LIN ; Bei SUN ; Shiyou YANG ; Ling LV ; Yu LIU
Traditional Chinese Drug Research & Clinical Pharmacology 2000;0(05):-
Objective To study the influence of guiding herb of Radix Achyranthis Bidentatae(RAB) on therapeutic effect of diclofenac sodium for rats with adjuvant arthritis(AA) and its possible mechansim,and to further explore the pharmacodynamic and pharmacokinetic changes after using diclofenac sodium together with RAB.Methods Forty-five Wistar rats were equally divided into 5 groups:normal group,model group,RAB(RAB water extract 5.0 g?kg-1) group,diclofenac sodium(10 mg?kg-1) group,and the combination group.The rat model was induced by Freud's complete adjuvant.The foot edema was tested by volume method.HPLC was used to determine the diclofenac sodium concentration in foot tissue,and ELISA and radioimmunoassay method were used to determine PGE2 and IL-1?levels in vivo.Results In the combination group,the anti-inflammatory action was superior to that in diclofenac sodium group(P