OBJECTIVE:To study the bioavailability of the domestic and the imported zolmitriptan tablets in human body.METHODS:The plasma concentration of zolmitriptan in24healthy male volunteers were determined by HPLC-FI after o?rally administered with single dose of5mg zolmitriptan tablets by randomized crossover way,the pharmacokinetics parameters and the relative bioavailability of which were calculated.RESULTS:The plasma concentration-time curves of the oral zolmitriptan tablets fitted one-compartment open model of linear dynamics,the main parameters of domestic tablets and im?ported tablets were described as follows,C max (8.273?3.379)ng/ml and(7.756?2.623)ng/ml,t max (2.341?1.169)h and(2.644?1.121)h,AUC 0～t (47.95?15.75)(ng?h)/ml and(46.27?13.71)(ng?h)/ml,the relative bioavailability of do?mestic zolmitriptan tablets and the imported tablets was(106.72?32.03)%.CONCLUSION:The domestic and the imported zomitriptan tablets is bioequivalent.

Objective To investigate the hand washing state and its influencing factors in patients undergoing infusion in outpatient clinic in order to adopt measures to enhance the patients' consciousness of hand hygiene. Methods 300 adult patients undergoing infusion in outpatient clinic were investigated.The bacteria condition before and after washing hands was observed. The condition and washing apparatus in the infusion room were also evaluated. Results The bacteria amount in the hands of patients undergoing infusion was 20 to 36 times higher than the standard level. The washing apparatus was simple and did not reach the standard requirement. Conclusion We should strengthen the propaganda of hand hygiene knowledge to patients undergoing infusion and improve their recognition of the importance of hand washing. The hospital should improve the washing facilities to reduce hospital infeciton.

OBJECTIVE:To realize automatic central drug dispensing model in hospital pharmacy.METHODS:The construction,running condition,major function and flow-sheet of automatic oral drug dispensing system of our hospital was introduced,and the automatic drug dispensing system was compared with traditional dispensing system.RESULTS:The automatic oral drug dispensing system could enhance the speed and accuracy of drug dispensing,shorten waiting time of nurse,improve health condition and decrease medicine pollution.CONCLUSION:The automatic oral drug dispensing system is suitable for drug dispensing in hospitals and conducive to the enhancing of pharmaceutical care level.

OBJECTIVE:To analyze the causes of drug quality events took place in our hospital so as to provide reference for the improvement of drug quality.METHODS:Systematic investigations were performed on 150 batches of drugs that had shown quality problems during 2005 and 2006 in our hospital and the possible reasons accountable for the problems were analyzed.RESULTS & CONCLUSIONS:The quality problems were originated from 3 links including production,distribution and use of drugs,and manifested as improper or wrong packaging,labels or package inserts,inappropriate handling,and improper operation of medical staff etc,which worth the highest alert of the concerned departments.

Base Sequence ; Hepacivirus ; drug effects ; genetics ; Hepatitis C ; drug therapy ; virology ; Humans ; Molecular Sequence Data ; Oligonucleotides ; therapeutic use ; Phosphorothioate Oligonucleotides ; therapeutic use

0.05.The neuronal necrosis area in group A are significantly higher than group B and C [(1.8?0.7)vs(0.9?0.4)and(0.6?0.3),both are P0.05.The neuronal necrosis area and the level of NSE in fetus were positively correlated with each other,r=0.798,P0.05.The volume of mitochondria of nerve cells in group A and B are significantly higher than that of group C [(7.0?1.8)?10~(-4)?m~3 and(5.7?1.6)?10~(-4)?m~3 vs(3.2?1.2)?10~(-4) ?m~3,both are P0.05). Conclusions There is apparente pathological change of fetal rats brain in cholic acid groups,the neuronal degeneration and the mitochondria swelling was mainly found in low cholic acid group,the neuronal necrosis and the mitochondria decrease was mainly found in high cholic acid group.The serum concentration of TBA and NSE in fetal rats were positively correlated with each other.

The resection can be performed in about 20 percent of patients with primary hepatocellular carcinoma(PHC) in clinic. However, with the development of interventional treatment such as transcatheter arterial chemoembolization(TACE), better therapeutic effect has been achieved by two-stage resection such as TACE in patients with unresectable PHC. At present, surgical resection is still regarded as the first choice of PHC, and the principle of comprehensive therapeutic solutions around surgical operation has been established. The pretreatment of TACE is an important measure to improve the therapeutic effect in PHC.This paper discussed the mechanism, effect and value of TACE in pretreatment of unresectable PHC. The selection of operative opportunity, sign, and ways after TACE and the factors affecting prognosis of two-stage resection were also reviewed.

Objective To discuss the effect of psychological intervention on prevention of posloperation infection in patients with breast cancer .Methods 336 patients with breast cancer after operation were divided into the control group and the intervention group with 168 cases in each group.The control group received routine nursing while the intervention group Was given psychological intervention based upon routine nursing.The incidence of postopemtion infection was observed in the two groups.Results Incidenc of infection took place in 27 patients(8.04%)among 336 cases.The incidence rate infection in the control group was 12.50%,which was evidently higher than that of the intervention group(3.57%),x2=9.06,P＜0.01.The infection location and time in the intervention group was better than that of the control group.Conclusion Psychological intervention could reduce the incidence rate of posteperation infection in patients with breast cancer.

Objective To observe the effects of truncated type Ⅱ receptor of TGF ? 1 expressing plasmid on rat liver fibrosis. Methods An eukaryotic expression plasmid of a truncated type Ⅱ receptor of TGF ? 1 was constructed by recombinant DNA technique. Sequence analysis of this recombinant plasmid revealed that it contained the complete extracellular and transmembrane domains of TGF ? 1 Ⅱ receptor but lacked most of the cytoplasmic kinase domain. The recombinant plasmid encapsulated by liposome was transferred into the rats by intraperitoneal injection and its effects on the grade of the pathologic fibrosis and the levels of HA,LN,PCⅢ,Ⅳ C were observed. Results The levels of serum HA,LN,PCⅢ,Ⅳ C were lower in the early treatment group than those in the model control group ( P 0.05). Either in the early or later treatment group, the grade of liver fibrosis was decreased apparently compared with the model control group ( P

0 05) The Kappa value was 0 83 and intraobserver agreement was bet ter b etween SeO 2 and SpO 2 .ConclusionThe sensor sticked to earlobe is feasible and simple to monitor puls oxygen saturation continuousl y in children