A growing body of research concerns about the mental psychological intervention involved in the treatment of chronic pain. It still continue reported that combining with mental psychological intervention in pain management could relieve pain level, therefore improve quality of lives. Common psychological intervention including psychological and pharmacological approach and psychological behavior approach both support their efficacy

Papillary thyroid cancer (PTC) is the most common type in thyroid carcinomas.Recently,the prevalence and diagnostic rate of PTC has got significantly high with the general use of ultrasound.Nowadays,more and more studies have suggested that the coexistence of PTC and diabetes is common.They indicated that hyperglycemia would induce the deterioration of oxidative stress injury,chronic inflammation,insulin resistance,obesity,dyslipidemia,deficiency of vitamin D and dysimmunity.All of these may break the balance of oxidation and antioxidation and result in disordering signal pathway,accumulation of inflammatory cytokines,over activating of insulin and insulin-like growth factor-1,changing the metabolic pathways,which will promote the occurrence and progression of PTC.

OBJECTIVE:To provide reference for the prevention,diagnosis and treatment of drug eruptions in the clinic. METHODS:A total of 102 drug eruption cases from 1998 to 2007 in our hospital were analyzed in respect of the allergizing drugs and the types and the clinical features of the drug eruptions. RESULTS: The drug eruptions were mostly induced by antimicrobials (45 cases),followed by antipyretic analgesics (15 cases) and Chinese medicines (15 cases). Erythema polymorphe (39 cases) was the most common clinical type,followed by urticaria (18 cases) and fixed erythema (15 cases). CONCLUSION: Clinician should attach great importance to patients' drug allergic history and medication history so as to reduce the incidence of drug eruption.

The training of clinical thinking ability is the key point of obstetrical teaching to medical students in eight-year program.Obstetrical department of the third affiliated hospital of Sun Yat-sen university has put forward specific methods of SP inquiring and PBL case analysis teaching.The well-designed teaching methods have an active role in the training of case history collecting ability,diagnosing and treating ability to medical students in eight-year program.

Objective To observe the distribtuion of NOS positive neurons in the projecting pathway to the subnucleus reticularis dorsalis(SRD) in the rat. Methods We used a double staining technique combined retrograde tract tracer and NADPH d histochemistry. Results FG/NOS double labeled neurons were found in the laminae Ⅰ,Ⅹ of spinal cord,dorsal raphe nucleus(DR),linear raphe nucleus(LR),and raphe obscurus nucleus(RO).In the periaqueductal gray(PAG),there were many FG labeled or NOS labeled neurons,but no FG/NOS double labeled neurons were found.Conclusion\ NO might play a role in the pathway of afferent projections of the SRD.\;[

OBJECTIVE:To investigate the pathogen distribution and drug resistance situation in bronchoalveolar lavage fluid (BALF) from patients with refractory pulmonary infection,and provide reference for clinical rational drug use. METHODS:The sputum and BALF specimen of 136 inpatients with refractory pulmonary infection from the First People’s Hospital of Zhenjiang City from Jan. 2012 to Dec. 2015 were cultured and identified,pathogen detection was compared,and results of drug sensitivity test for pathogen in BALF specimen was analyzed. RESULTS:The positive rates of sputum and BALF specimen of 136 inpatients were 22.06%and 47.79%,with statistical significance(P<0.01);a total of 32 and 72 strains were isolated,they mainly were Ste-notrophomonas maltophilia,Pseudomonas aeruginosa,Acinetobacter baumannii and Staphylococcus aureus. S. maltophilia in BALF was sensitive to minocycline and levofloxacin;resistance rate of P. aeruginosa to common antibiotics was lower than 50%;A. baumannii was sensitive to imipenem,ampicillin sodium and sulbactam sodium,amikacin and minocycline;S. aureus was sen-sitive to linezolid,chloramphenicol and vancomycin. CONCLUSIONS:The positive rate of BALF specimen is higher than spu-tum,the pathogens are mainly Gram-negative bacteria. Clinic should rationally select antibiotics based on the drug sensitivity test and clinical symptoms.

Objective In the present study, we observed the distribution of nitric oxide synthase positive neurons in the developing rat telencephalon and to realize the possible roles of NO in brain development further. Methods NADPH-d histochemical method was used to investigate the micromorphology and distribution of NOS positive neurons in rat telencephalon from embryonic day 14 (El4) to postnatal day 14 (P14). Results At El4, no neurons stained. Labeling was observed in the ventrolateral of the striatum at E15. At E17, positive neurons were seen in the cerebral cortex and piriform cortex. They were cells with small cell bodies, shorter dendrites and less ramification. The stained neurons were either increased or maintained in both number of neurons and intensity during development. At E20, positive cells were found in many regions. Many positive neurons were present in the piriform cortex, ventrolateral of the striatum and bed nucleus of the stria terminalis. They acquired larger size and more complex dendrites. After birth, intensely stained NOS positive fibers were distributed widely in the cerebral cortex and striatum. Stained cells were found in the corpus callosum and hippocampus also. The distribution pattern of positive cells at P14 was essentially similar to that reported in adult rats. Conclusion The distinctive temporal and spatial expression pattern of nitric oxide synthase positive neurons in the telencephalon indicated that NO may play an important role in brain development and maturation.

As a result of the increasing use of radiologic contrast medium in patients, especially the elderly in severe or clinical condition with attendant comorbidities, such as diabetes mellitus, renal failure, cardiac failure, and volume depletion. Contrast induced nephropathy(CIN)is now the third most common cause of hospital-aquired renal failure and accounts for approximately 11% of the cases. This article mainly introduces the evaluation of laboratory investigations providing insights into the pathophysiology of this disorder and the examination of the important clinical data of CIN including risk factors and diagnosis. The last section deals with renal protection and preventive strategies.

In order to study the new function of riboflavin, the experiments of ri-boflavin on the prevention of teratogenesis were conducted. The experimental rats were divided into four groups A,B,C,D. A served as a control group, B,C,D, were given 50?g, 250ng and 1000?g of riboflavin respectively for one week intragastrically prior to the study. After pregnancy, all rats including controls were given teratogenic pesticide Dikushuang 0.75mg/kgbw for contaminaton intragastrically, riboflavin being given continually as before, to observe the effects on body weight growth and hemoglobin level of pregnant rats. The following parameters were measured: the reproduction of pregnant rats, the development of fetus and the teratogenic activity of fetus after animals were killed. The experimental results showed that the average body weight gain in the each dose groups of riboflavin were higher than the control group, but the difference was not significant. The hemoglobin levels at various experimental times were less significant among the groups.The rates of the resorption and the living fetus in 250?g and 1000?g groups were significantly lower than the control (P

Objective To compare the efficacy and toxicity of late-course concurrent radiochemotherapy and sequential chemoradiotherapy for advanced esophageal carcinoma. Methods Eighty-two patients with advanced esophageal carcinoma were randomized into two groups: 41 cases in late-course concurrent radiochemotherapy (LCRC) group were received two cycles chemotherapy and then underwent concurrent radiochemotherapy;41 cases in sequential chemoradiotherapy (SCR) group were received four cycles chemotherapy and then underwent radiotherapy. The regimen of chemotherapy in all cases:cisplatin 25mg/m2, 1-3 d;calcium folinate (CF) 150 mg/m2, 1-5 d;fluorouracil 375 mg/m2, 1-5 d, 21 d was one cycle. All patients were received the three-dimensional conformal radiation therapy, the total dose of radiation was same as 64 Gy. Results The short-term response rate was 85.4%(35/41) in LCRC group and 65.9%(27/41) in SCR group, they had significant difference ( P<0.05). The rates of acute radiation esophagitis that need treatment was 90.2%(37/41) in LCRC group and 87.8%(36/41) in SCR group, there had no significant difference (P>0.05). The l year, 2 years, 3 years survival rate were 68.3%(28/41) and 65.9%(27/41), 56.1%(23/41) and 51.2%(21/41), 46.3%(19/41) and 36.6%(15/41) respectively,the median survival time were 30.0 months and 26.0 months, there had no significant difference ( P>0.05). Conclusion The short-term efficacy of advanced esophageal carcinoma could be improved by the late-course concurrent radiochemotherapy.