Papillary thyroid cancer (PTC) is the most common type in thyroid carcinomas.Recently,the prevalence and diagnostic rate of PTC has got significantly high with the general use of ultrasound.Nowadays,more and more studies have suggested that the coexistence of PTC and diabetes is common.They indicated that hyperglycemia would induce the deterioration of oxidative stress injury,chronic inflammation,insulin resistance,obesity,dyslipidemia,deficiency of vitamin D and dysimmunity.All of these may break the balance of oxidation and antioxidation and result in disordering signal pathway,accumulation of inflammatory cytokines,over activating of insulin and insulin-like growth factor-1,changing the metabolic pathways,which will promote the occurrence and progression of PTC.

OBJECTIVE:To provide reference for the prevention,diagnosis and treatment of drug eruptions in the clinic. METHODS:A total of 102 drug eruption cases from 1998 to 2007 in our hospital were analyzed in respect of the allergizing drugs and the types and the clinical features of the drug eruptions. RESULTS: The drug eruptions were mostly induced by antimicrobials (45 cases),followed by antipyretic analgesics (15 cases) and Chinese medicines (15 cases). Erythema polymorphe (39 cases) was the most common clinical type,followed by urticaria (18 cases) and fixed erythema (15 cases). CONCLUSION: Clinician should attach great importance to patients' drug allergic history and medication history so as to reduce the incidence of drug eruption.

A growing body of research concerns about the mental psychological intervention involved in the treatment of chronic pain. It still continue reported that combining with mental psychological intervention in pain management could relieve pain level, therefore improve quality of lives. Common psychological intervention including psychological and pharmacological approach and psychological behavior approach both support their efficacy

Objective To estimate the effect of the NO on the medial amygdaloid nucleus(Me), we studied the origins of the NOS positive terminals in the Me. Methods Noergic afferent projection to Me was identified by a combined NADPH-d histochemical staning and retrograde CTb immunocytochemical method after microinjecting CTb into Me. Results The double labeled of neurons (NOS and CTb) were located in dorsal raphe nucleus, locus ceruleus, basolateral amygdaloid nucleus, parabrachial nucleus, ventrolateral part of periaqueductal gray.Conclution The NADPH-d positive terminals in the Me originates from the aforementioned nucleus, and may relate to the function of the Me.

In order to study the new function of riboflavin, the experiments of ri-boflavin on the prevention of teratogenesis were conducted. The experimental rats were divided into four groups A,B,C,D. A served as a control group, B,C,D, were given 50?g, 250ng and 1000?g of riboflavin respectively for one week intragastrically prior to the study. After pregnancy, all rats including controls were given teratogenic pesticide Dikushuang 0.75mg/kgbw for contaminaton intragastrically, riboflavin being given continually as before, to observe the effects on body weight growth and hemoglobin level of pregnant rats. The following parameters were measured: the reproduction of pregnant rats, the development of fetus and the teratogenic activity of fetus after animals were killed. The experimental results showed that the average body weight gain in the each dose groups of riboflavin were higher than the control group, but the difference was not significant. The hemoglobin levels at various experimental times were less significant among the groups.The rates of the resorption and the living fetus in 250?g and 1000?g groups were significantly lower than the control (P

Objective In the present study, we observed the distribution of nitric oxide synthase positive neurons in the developing rat telencephalon and to realize the possible roles of NO in brain development further. Methods NADPH-d histochemical method was used to investigate the micromorphology and distribution of NOS positive neurons in rat telencephalon from embryonic day 14 (El4) to postnatal day 14 (P14). Results At El4, no neurons stained. Labeling was observed in the ventrolateral of the striatum at E15. At E17, positive neurons were seen in the cerebral cortex and piriform cortex. They were cells with small cell bodies, shorter dendrites and less ramification. The stained neurons were either increased or maintained in both number of neurons and intensity during development. At E20, positive cells were found in many regions. Many positive neurons were present in the piriform cortex, ventrolateral of the striatum and bed nucleus of the stria terminalis. They acquired larger size and more complex dendrites. After birth, intensely stained NOS positive fibers were distributed widely in the cerebral cortex and striatum. Stained cells were found in the corpus callosum and hippocampus also. The distribution pattern of positive cells at P14 was essentially similar to that reported in adult rats. Conclusion The distinctive temporal and spatial expression pattern of nitric oxide synthase positive neurons in the telencephalon indicated that NO may play an important role in brain development and maturation.

As a result of the increasing use of radiologic contrast medium in patients, especially the elderly in severe or clinical condition with attendant comorbidities, such as diabetes mellitus, renal failure, cardiac failure, and volume depletion. Contrast induced nephropathy(CIN)is now the third most common cause of hospital-aquired renal failure and accounts for approximately 11% of the cases. This article mainly introduces the evaluation of laboratory investigations providing insights into the pathophysiology of this disorder and the examination of the important clinical data of CIN including risk factors and diagnosis. The last section deals with renal protection and preventive strategies.

Objective To observe the distribtuion of NOS positive neurons in the projecting pathway to the subnucleus reticularis dorsalis(SRD) in the rat. Methods We used a double staining technique combined retrograde tract tracer and NADPH d histochemistry. Results FG/NOS double labeled neurons were found in the laminae Ⅰ,Ⅹ of spinal cord,dorsal raphe nucleus(DR),linear raphe nucleus(LR),and raphe obscurus nucleus(RO).In the periaqueductal gray(PAG),there were many FG labeled or NOS labeled neurons,but no FG/NOS double labeled neurons were found.Conclusion\ NO might play a role in the pathway of afferent projections of the SRD.\;[

Objective To compare the efficacy and toxicity of late-course concurrent radiochemotherapy and sequential chemoradiotherapy for advanced esophageal carcinoma. Methods Eighty-two patients with advanced esophageal carcinoma were randomized into two groups: 41 cases in late-course concurrent radiochemotherapy (LCRC) group were received two cycles chemotherapy and then underwent concurrent radiochemotherapy;41 cases in sequential chemoradiotherapy (SCR) group were received four cycles chemotherapy and then underwent radiotherapy. The regimen of chemotherapy in all cases:cisplatin 25mg/m2, 1-3 d;calcium folinate (CF) 150 mg/m2, 1-5 d;fluorouracil 375 mg/m2, 1-5 d, 21 d was one cycle. All patients were received the three-dimensional conformal radiation therapy, the total dose of radiation was same as 64 Gy. Results The short-term response rate was 85.4%(35/41) in LCRC group and 65.9%(27/41) in SCR group, they had significant difference ( P<0.05). The rates of acute radiation esophagitis that need treatment was 90.2%(37/41) in LCRC group and 87.8%(36/41) in SCR group, there had no significant difference (P>0.05). The l year, 2 years, 3 years survival rate were 68.3%(28/41) and 65.9%(27/41), 56.1%(23/41) and 51.2%(21/41), 46.3%(19/41) and 36.6%(15/41) respectively,the median survival time were 30.0 months and 26.0 months, there had no significant difference ( P>0.05). Conclusion The short-term efficacy of advanced esophageal carcinoma could be improved by the late-course concurrent radiochemotherapy.

BACKGROUND: Quite a few deoxidized reduced form of nicotinamide-adenime dinucleotide phosphate (NADPH-d) -positive neurons distribute in amygdala complex (AMC) and gamma-aminobutyric acid(GABA)is an important inhibitory neurotransmitter that also widely distributes in the central nervous system (CNS) of mammals. Whether there is coexistence of GABA and nitricoxide synthase (NOS) in AMC is unknown at present.OBJECTIVE: To observe whether there is GABA and NADPH-d-eoexist neuron in cortical nucleus of amygdala (Co) with the combination of NADPH-d hischemical and immunohistochemical double staining.DESIGN: A verifying controlled study based on the experimental animals.SETTING: Department of anatomy of two universities MATERIALS: The study was conducted in the department of Anatomy,Medical College of Zhejiang University between May 2004 and June 2004. Six SD rats in either gender with a body mass between 250 g and 300 g were selected.INTERVENTIONS: Coronary serial frozen slices of brain tissue were prepared. 4 sets of slices were selected for Nissl staining, NADPH-d histochemical staining, NADPH-d histochemical and GABA immunohistochemical double staining, and control experiment for the test of antibody specificity. GABA-labeled neurons, NADPH-d-positive neurons, and NADPH-d/GABA double-labeled neurons were counted in Co nucleus for the calculation of the percentage of double-labeled positive neurons to single-labeled positive neurons.MAIN OUTCOME MEASURES: Distribution of NADPH-d/GABA double labeled neuron; distribution of NADPH-d or GABA single labeled neuron.RESULTS: Most of GABA-positive neurons distributed in posteromed cortical amygdaloid nucleus (PMCo), posterolateral cortical amygdaloid nucleus (PLCo), which were mainly small types but few middle types. Most of NADPH-d-positive neurons distributed in PMCo, PLCo and anterior cortical amygdaloid nucleus (Aco), which were mainly middle sized and small sized neurons. The ratio of NADPH-d/GABA double-labeled neurons to single labeled neuron was 24.5% (GABA) or 46.7% (NADPH-d).CONCLUSION: There is GABA/NADPH-d-coexist neuronsin Co of rats,which suggests NO might have modulative effect on GABA neuron in Co.