Objective To investigate the impacts of Xuebijing injection on systemic inflammatory response and immune function of patients with acute exacerbation of severe chronic obstructive pulmonary disease (AECOPD). Methods A prospective randomized controlled trial (RCT) was conducted. Forty patients with severe AECOPD were divided into control group and Xuebijing group in accordance with the random number table, each group 20 cases. Both groups were treated by routine conventional basic therapy of severe AECOPD including anti-infection, phlegm-expelling formula, bronchodilators and mechanical ventilation, etc, while in Xuebijing group, intravenous drip of Xuebijing (100 mg, twice a day for 5 days) was additionally used. The changes of data of arterial blood gas analysis, blood routine examination, C-reactive protein (CRP), procalcitonin (PCT), immune function, and acute physiology and chronic health evaluation system Ⅱ (APACHE Ⅱ) score before and after therapy were observed and compared between the two groups. The length of stay in hospital, duration of mechanical ventilation, and prognosis were also compared between the two groups. Besides, according to the difference in APACHE Ⅱ score, all the patients were divided into APACHEⅡscore≥15 score group (18 cases) and APACHEⅡscore<15 score group (22 cases), and the immune function were compared between the two groups. Results ①The immune function was descended and disordered in patients with severe AECOPD. Compared with the < 15 score group, the expressions of CD45+, CD3+, CD4+, CD4+/CD8+ ratio, B-lymphocyte, natural killer cell (NK cell) in ≥ 15 score group were significantly lowered [CD45+(×106/L):663.92±100.61 vs. 1 289.92±169.38, CD3+(×106/L):342.05±108.93 vs. 882.37±172.56, CD4+(×106/L):205.96±63.97 vs. 486.24±108.64, CD4+/CD8+ratio:0.76±0.49 vs. 1.32±0.57, B-lymphocyte (×106/L):124.77±32.72 vs. 166.06±48.02, NK cells (×106/L): 186.47±39.57 vs. 243.51±44.72, all P < 0.05]. There was no statistically significant difference in the expression of CD8+ between the ≥ 15 score group and < 15 score group (P > 0.05). ② Compared with those before therapy, the pH value, oxygenation index, arterial partial pressure of carbon dioxide (PaCO2), white blood cell count (WBC), CRP, PCT were significantly improved after therapy in both control and Xuebijing groups. Compared with those in the control group, WBC, CRP, PCT were significantly lowered in Xuebijing group [WBC (×109/L): 10.29±3.83 vs. 12.69±3.42, CRP (mg/L): 9.06±4.19 vs. 15.26±4.22, PCT (ng/L): 0.18±0.21 vs. 0.42±0.24, all P < 0.05]. There were no statistically significant differences in pH value, oxygenation index and PaCO2 between two groups (all P>0.05). The degrees of improvement of CD45+, CD3+, CD4+, CD8+ and CD4+/CD8+ ratio were more remarkable in Xuebijing group after treatment than those in control group [CD45+ (×106/L): 1 079.38±153.86 vs. 1 015.63±157.11, CD3+ (×106/L): 652.05±100.05 vs. 596.81±106.85, CD4+ (×106/L): 358.92±67.53 vs. 329.99±72.61, CD8+ (×106/L): 205.73±35.19 vs. 230.41±39.74, CD4+/CD8+ratio: 2.16±0.63 vs. 1.52±0.54, all P < 0.05]. The B-lymphocyte and NK cell before treatment and after treatment showed no statistical significant differences between the two groups (all P > 0.05). Compared with the control group, the duration of mechanical ventilation (hours: 56.25±22.87 vs. 69.45±26.59) and the length of stay in hospital (days: 11.00±0.74 vs. 14.00±2.06) were shortened, and APACHE Ⅱ score was significantly lowered in Xuebijing group (8.21±2.97 vs. 12.08±3.12, P < 0.05). The numbers of multiple organ failure and dead patients in Xuebijing group were less than those of control group, but no statistical significant differences were found (both P > 0.05). Conclusion Xuebijing injection for treatment of patients with severe AECOPD can ameliorate inflammatory response, improve immune function, shorten the duration of mechanical ventilation and the length of stay in hospital, and decrease the risk of death.

Objective To understand the clinical distribution and drug resistance situation of112 strains of Acinetobacter Bau-mannii isolated from the patients′sputum samples in cerebral surgery ICU in order to provide the basis for the rational use of anti-bacterial drugs in clinical therapy.Methods 112 strains of Acinetobacter Baumannii were performed the retrospective analysis.The VITEK2-Compact automatic microbiological analyzer was adopted to conduct the bacterial identification and the drug susceptibility test and the K-B method was combined as the supplement control.The Whonet 5.6 software was used for conducting the statistical analysis.Results Among 112 strains of Acinetobacter baumannii,75 strains(67.0%)were multi-drug resistant,8 strains(7.1%) were pan-resistant.The antimicrobial susceptibility tests showed that the resistant rates of Acinetobacter baumannii to mezlocillin, piperacillin and nitrofurantoin reached up to 100%.Acinetobacter Baumannii had the lower resistant rate to polymyxin B (2.7%), the resistant rates to minomycin and ceperazone/sulbactam were 4.5% and 10.7% respectively.Conclusion The drug resistance phenomena of Acinetobacter Baumannii in the cerebral surgery department ICU is serious.Minomycin,polymyxin B and ceperazone/sulbactam have the better antibacterial activities to clinically isolated Acinetobacter Baumannii and may be the alternative drugs for therapy.Clinic should strengthen the monitoring and rationally use the antibacterial drugs.

Cardiac Catheterization ; trends ; Forecasting ; Heart Defects, Congenital ; therapy ; Humans

Arrhythmias, Cardiac ; therapy ; Biomedical Research ; methods ; standards ; Catheter Ablation ; Child ; China ; Drug Therapy ; Humans

On inheriting the doctrines of Li Dong-yuan's'Internal damage of spleen and stomach causes diverse illnesses'and YE Gui's moistening stomach-yin etc.,Professor LU Zhi-zheng elaborates their academic thoughts further and proposes the core of spleen and stomach regulation in modern times——'cotrolling the center,operating four sides,keeping happy emotion,regulating ascending and descending,considering moistening and dryness,normalizing food and drink'.He does not only apply spleen and stomach to treat spleen and stomach illness but also treat vertigo,thoracic obstruction,cardialgia,apoplexy,liver and kidney diseases,rheumatosis and so on,which are all effective.However,as times,diets and living habits are changing,as well as social environment is different,the spleen and stomach diseases,which are caused by people's unhealthy diet,irregular work and rest,overworking and high spiritual pressure of work in this modern society with profound food and clothing and highly developed material civilization,has changed greatly from the spleen and stomach theory in Dongyuan times.In this case,Professor LU experiences that the reason for injured spleen and stomach in modern society has its unique pathogenic factor,thus sets up the etiology and pathogenesis for spleen and stomach of internal injury in the new times.

The current situation demands that the medical English teaching in medical colleges should aim to cultivate more practical and professional medical staff.To improve teaching,the exploration was made and some suggestions were put forward.

Taking the teaching process of the medical immunology curriculum as a master line,the curriculum restructuring as the method and the big sample investigation results as the basis,this article advocates teaching with heart,establishing curriculum with the sentiment,in order to interlink the heart of teachers and students and reach mutual understanding.

It’s a problem faced by most institutions how to make employment more standardized and legalized after Implement of Labor Contract Law of People's Republic of China. So the author studied employment mode and management mode of workforce out of organization primarily, and explored some problems produced after Implement of Labor Contract Law of People's Republic of China in order to find out perfect management method and employment mode. It has certain practical significance and guiding role.

Objective:To investigate the relationship between the level of soluble Fas antigen(sfas) and soluble Fas ligand(sFasL) and endometriosis associated infertility.Methods:The sfas and sFasL level in sera and peritoneal fluid of infertile women with endometriosis were assessed with enzyme-linked immunosorbent assay,and were compared with those of 14 infertile women resulting from chronic pelvic infectious disease and 16 fertile controls.Results:The sFasL levels(175.09?80.50pg/ml in sera and 284.50?152.38pg/ml in peritoneal fluid) were significantly higher in infertile patients with endometriosis than those of infertile controls(88.47?43.55pg/ml in sera and 17.30?9.62pg/ml in peritoneal fluid) and fertile controls(16.13?11.75pg/ml in sera and 8.84?2.31pg/ml in peritoneal fluid).Compared with the levels of sfas in infertile women resulting from pelvic infectious disease(868.75?570.48pg/ml in sera and 181.76?157.78pg/ml in peritoneal fluid) and fertile control group(822.26?129.12pg/ml in sera and 318.42?145.16pg/ml in peritoneal fluid),the values of sfas in infertile patients with endometriosis(828.60?429.65pg/ml in sera and 349.6?288.89pg/ml in peritoneal fluid) have no significant difference.Conclusion:Endometriosis-related infertility has great association with the level of sFasL,and sFasL may play a key role in the local homeostatic regulation in endometriosis and in turn result in the development of its associated infertility.

Tai Chi Chuanis a traditional Chinese method of regimen and health care, which has attracted wide attention from countries in the world. This article was aimed to analyze the current situation and hot spots about Tai Chi Chuan for future research. A total of 1349 articles were retrieved from Web of Science from 1981 to 2013. CiteSpace was used to map knowledge domain of 1349 articles in order to explore the current situation and hot spots aboutTai Chi Chuan internationally. The results showed that the research onTai Chi Chuan showed a rising trend. The main research regions were in the United States and China. The research fields were extended from medicine and sport science to psychology, engineering and computer science. The hot spots were focused on physical control, psychology and cardiovascular diseases. It was concluded thatTai Chi Chuan was a method benefit to both physical and mental health. The focus of future Tai Chi Chuan research was on basic theory, action mechanism and strict evidences.