Objective:To design ultrasonic atomization device making use of disposable water cup, to improve ventilation therapy in clinical application.Methods: The design take advantage of working principal of ultrasonic atomization, do a simple interface compatible work to the disposable water cup, the water cup can realize the ability of medicine atomization treatment, collecting the water when not do atomization; the water cup access into the ventilator pipe, to test the influence between the atomization and ventilator function.Results: The disposable water cup realized ultrasonic atomization successfully, and shows no influence between the atomization and ventilator self-function.Conclusion: The design has made some simple improvement of the disposable water cup on the structure, proposed a new way of ventilator atomization practically and economically.

Proprotein convertase subtilisin/kexin type 9(PCSK9)inhibitors not only have good lipid-lowering effects,but also have pleiotropic effects such as improving cardiovascular outcomes,re-lieving anti-inflammation,relieving oxidative stress and improving vascular endothelium.In recent years,the continuous development of PCSK9 inhibitors provides new ideas for the treatment of cardio-vascular diseases.This article reviewed the pleiotropic mechanisms of PCSK9 inhibitors,especially on vascular endothelial function.

Proprotein convertase subtilisin/kexin type 9(PCSK9)inhibitors not only have good lipid-lowering effects,but also have pleiotropic effects such as improving cardiovascular outcomes,re-lieving anti-inflammation,relieving oxidative stress and improving vascular endothelium.In recent years,the continuous development of PCSK9 inhibitors provides new ideas for the treatment of cardio-vascular diseases.This article reviewed the pleiotropic mechanisms of PCSK9 inhibitors,especially on vascular endothelial function.

Objective To investigate the method of modeling, finite element modeling and AnyBody musculoskeletal multi-body dynamics simulation technique analyze the biomechanics of clinical orthopaedic surgery. Methods The AnyBody software was used to establish the musculoskeletal motor model of the individualized upper limbs according to the height, weight and CT data of the volunteers. The flexion motion of the elbow in normal people was simulated, and the muscle force, joint force, torque, constraint condition of the humerus during the flexion movement were derived and used as the boundary conditions of finite element analysis.Then, the 3D reconstruction was conducted in the MIMICS software based on CT data. In the Geomagic Studio software, the humeral curved surface and position coordinate matching were completed, and grid division and material assignment were done in the HyperMesh software. Finally, the 3D reconstruction for finite element model of the humerus was introduced into ABAQUS software. The boundary condition data derived from the AnyBody software were applied and the stress calculation analysis was performed. Results The results of the stress and displacement of the humerus during elbow flexion motion were calculated in the ABAQUS software. The maximum stress and displacement of the humerus were 0.76 MPa and 20 μm when flexion of the elbow joint was about 90°. Conclusions A continuous dynamic analysis of humeral stress and displacement during elbow flexion motion was realized, which was more consistent with the requirements of human physiological anatomy and could provide an efficient analysis platform and a new way for studying clinical orthopedic problems.