1.The clinical characteristics of cognitive impairments in subarachnoid hemorrhage patients with negative digital subtraction angiography
Xinping ZHANG ; Yingchun LIANG ; Jun ZHAO ; Linchen QIN
Chinese Journal of Behavioral Medicine and Brain Science 2012;21(7):591-592
ObjectiveTo estimate the cognitive function of subarachnoid hemorrhage patients with negative digital subtraction angiography(DSA),and analyse its relevant factors and clinical characteristics.Methods 96 subarachnoid hemorrhage patients were selected,and the disease condition were classfied into different grades by Fisher scale,Hunt-Hess scale and the cognitive function were estimated by mini-mental state examination (MMSE),then calculated its incidence,analysed the relationship between the classification and cognitive impairments.ResultsThe incidences of cognitive impairment in subarachnoid hemorrhage patients with negative DSA were 51.04%.Cognitive impairment was closely related to Hunt-Hess and Fisher grade (P< 0.01 ).ConclusionSubarachnoid hemorrhage patients with negative DSA exist different extent of cognitive impairment.The higher Hunt-Hess or Fisher grade,the more serious cognitive impairment.
2.Research progress on the pharmacological effects of maslinic acid
Linchen ZHANG ; Xiaoqin ZHANG ; Junping ZHANG
Journal of Pharmaceutical Practice and Service 2024;42(5):185-189
Maslinic acid is a pentacyclic triterpenoid that is widely found in natural plants such as olives and hawthorns.Maslinic acid has anti-tumor,anti-inflammation,anti-oxidation,antibacterial,cardiovascular protection,neuroprotection,and other pharmacological effects.In this paper,the research progress of pharmacological activities and the mechanism of action of maslinic acid were reviewed,which provides the basis for the development and utilization of maslinic acid in the future.
3.Mirror visual feedback training can improve the upper extremity functioning of children with spastic hemiplegia
Guohui NIU ; Jun WANG ; Xiaoli ZHANG ; Linchen LI ; Hongxing LIU ; Bo CUI ; Xin WANG ; Jiayang XIE ; Dengna ZHU
Chinese Journal of Physical Medicine and Rehabilitation 2022;44(8):707-711
Objective:To observe the effect of mirror visual feedback training on upper limb function and muscle tension in children with spastic hemiplegia resulting from cerebral palsy (SHCP).Methods:Seventy-six children aged 2-5 with SHCP were randomly divided into a control group of 33 and a treatment group 34. All were given routine occupational therapy, physical therapy, massage and physical agents. Each therapy session lasted 30 minutes daily, 5 times a week over 3 weeks as a course of treatment. There was a one week interval after each of 6 courses, so the total treatment lasted 6 months. The treatment group was additionally trained with mirror visual feedback with the same schedule. Before, as well as after 3 and 6 months of treatment, each patient′s upper limb motor function, fine motor function and muscle tone were evaluated using the Fugl-Meyer motor function assessment scale (FMA), the Peabody fine motor development scales (PDMS-FM), the modified Ashworth scale (MAS) and integrated electromyograms (iEMGs).Results:There were no significant differences between the two groups before treatment. After both 3 and 6 months significant improvement was observed in both groups′ average FMA score, PDMS-FM total score, grip, and visual motor integration. At both points the treatment group′s averages were significantly better than those of the control group. The average MAS and iEMG results, however, were not significantly different at either time point.Conclusions:For children with spastic hemiplegia caused by cerebral palsy, mirror visual feedback training can effectively improve upper limb functioning, but it cannot reduce their muscle tone.