Objective To implore FHIT expression in the tissue of cervical carcinoma and its clinical significance. Methods To determine the FHIT expression in 42 cases of cervical carcinoma by S2P immunohistochemical staining and to make a comparison with the normal one. Results The FHIT expression in normal tissue showed to be normal or even positive. No descending or short one occurred. The expression in cervical carcinoma was significantly low or short, abnormal one reached 57.14 %. The descending and short expression had something to do with histological type and grade (P 0.05). Conclusions The ascending or descending of FHIT expression plays an important role, which might influence the prognosis of cervical carcinoma.

Objective: To clarify the meaning and definition method of low-income group, summarize the current economic risk of disease for rural low-income group and the risk pooling effect of medical insurance system. Methods: Using literature research method to systematically review the relevant studies of economic risk of disease for low-income group in rural areas. Results: The risk pooling effects of various medical insurance systems are different. Conclusion: On the basis of defining low-income group scientifically, it is necessary to promote the economic risk protection effect of medical security schemes for low-income group in rural area.

OBJECTIVE: To investigate the therapeutic effect of treatment based on syndrome differentiation and its influence on the serum levels of testosterone and insulin in women with polycystic ovary syndrome (PCOS). METHODS: Forty-three women, diagnosed with PCOS as well as syndrome of kidney yin deficiency or syndrome of spleen qi deficiency, were enrolled in the study. Twenty-five PCOS women with syndrome of kidney yin deficiency were treated with traditional Chinese herbs for nourishing yin to reduce fire (nourishing yin group), and 18 PCOS women with syndrome of spleen qi deficiency were treated with herbs for invigorating spleen and replenishing qi (replenishing qi group). Body mass index (BMI), waist-to-hip ratio (WHR), waist circumference (WC), and the serum levels of insulin and testosterone before and after treatment were detected. RESULTS: Among the 43 cases, 20 cases had high serum testosterone level, in which 13 cases with syndrome of kidney yin deficiency, 7 cases with syndrome of spleen qi deficiency, but the difference had no statistic significance; 17 cases had high serum insulin level, in which 11 cases with syndrome of spleen qi deficiency, 6 cases with syndrome of kidney yin deficiency, the difference had statistic significance (P<0.05). In nourishing yin group, the serum levels of insulin and testosterone declined after treatment (P<0.05), and BMI, WHR and WC showed no significant changes. In replenishing qi group, the serum level of insulin declined after treatment (P<0.01), and BMI, WHR, WC and the serum level of testosterone showed no significant changes. CONCLUSION: Traditional Chinese herbs for nourishing yin to reduce fire can significantly reduce the serum levels of testosterone and insulin in PCOS women with syndrome of kidney yin deficiency, and herbs for invigorating spleen and replenishing qi can significantly reduce the serum level of insulin in PCOS women with syndrome of spleen qi deficiency.

Objective To characterize the C677T polymorphism of 5,10-methylenetetrahydrofolate reductase (MTHFR) gene in Xinjiang Uygur and Han nationality population.Methods The C677T polymorphism of MTHFR gene was detected by using PCR-restriction fragment length polymorphism (RFLP) in 134 Uygur and 166 Han nationality people.Results There were 3 MTHFR C677T genotypes,i.e.,CC,CT,and TT.A significant difference was observed in the frequency of CC,CT,and TT genotypes of MTHFR C677T polymorphism between Han and Uygur nationality people (21.7％,53.0％ and 25.3％ vs.16.4％,80.6％ and 2.96％,x2 =33.78,P ＜ 0.01).The frequency of CC,CT,and TT genotypes of MTHFR C677T polymorphism was 16.95％,79.67％,3.39％ respectively,in men of Uygur nationality,16.0％,81.33％,2.67％ respectively,in women of of Uygur nationality,25.8％,47.1％ and 27.1％ respectively in men of Han nationality,17.28％,59.26％ and 23.46％ respectively in women of Han nationality.There was no gender difference in the distribution of MTHFR C677T polymorphism in Han or Uygur nationality population (both P ＜ 0.05).Conclusions There is a significant difference between Uygur and Han nationality population,but no gender difference is observed,in the distribution of MTHFR C677T genotypes in Xinjiang Uygur Autonomous Region.

Objective To investigate the relationship between fatty liver prevalence and body mass index(BMI),dyslipidemia in physical examination population in Baoji area.Methods The height and weight of 10 476 cases of physical examination population were measured and then BMI was calculated.Serum TG,TC,LDL-C and HDL-C concentrations were also determined.Type-B ul-trasonic was used to diagnose fatty liver.The test results were analyzed statistically.Results Fatty liver detection rate of 10 476 physical examination people was 16.29%,the detection rate of abnormal blood lipid concentration was 45.31%;the detection rate of abnormal TG,TC,LDL-C and HDL-C concentrations were 33.05%,17.23%,15.48% and 10%;the prevalence of fatty liver in-creased with BMI(P <0.05);In male population,the detection rate of TG,LDL-C concentrations′abnormal increase,HDL-C con-centrations′abnormal decrease,and fatty liver were higher than that in female population(P <0.05);the detection rate of blood lip-id′s abnormal concentrations and fatty liver were different in people of different age(P <0.05).In male population the group with the highest detection rate of dyslipidemia and fatty liver was the middle-aged group,while in women population was the elderly group.Conclusion There was a significant correlation among BMI,dyslipidemia and fatty liver prevalence,which were different in age and gender.

Objective To investigate the correlation between fasting plasma glucose(FPG)and body mass index(BMI)among examination groups in Baoji area.Methods 55 328 cases of medical examination were measured height,weight and calculated BMI,then these were detected FPG,the test results were analyzed by statistics.Results The levels of FPG and BMI were significant differences between different gender groups and different age groups;Male and female with abnormal FPG detec-tion rates were 9.90%,5.50%;FPG abnormal detection rate of male higher than female (χ2=335.47,P<0.005).The sub-j ects were divided into four groups according to their BMI:low-weight,normal,overweight and obesity.The relevance ratio of 4 groups with abnormal FPG were 2.71%,5.93%,11.65% and 13.75%,with diabetes were 1.38%,3.18%,6.02% and 6.39%,with impaired fasting glucose (IFG)were 0.8%,2.75%,5.64% and 7.37%.The detection rate of abnormal FPG, IFG and DM detection rate increased with increasing BMI levels (P<0.005).Conclusion The levels of FPG was upward trend with increasing BMI,increased prevalence of diabetes in overweight and obese people.The middle-aged population is the focus of monitoring and intervention of obesity.Control BMI is an effective measure to reduce the occurrence of diabetes.

Objective To analyze feasibility and safety of sedation with midazolam combined with fentanyl and propofol in patients undergoing gastrointestinal endoscopy,and provide reference for clinical anesthesia.Methods 120 cases were selected with gastrointestinal endoscopy, then divided into observation group and control group randomly, 60 cases in each group, the observation group was anaesthetized by midazolam midazolam combined with fentanyl and propofol, the control group was anaesthetized by fentanyl combined with propofol, the change of heart rate, mean arterial pressure and oxygen saturation in different time between the observation group and the control group were compared, the induction time, the examining time, the recovery time and the time of leaving hospital, the incidence of hypotension, cardiac tachycardia, hypoxia and the incidence of adverse reactions were compared.Results The heart rate, mean arterial blood pressure and blood oxygen saturation decreased to the lowest level in 2 groups at T1.There was no significant difference in mean arterial pressure, heart rate and blood oxygen saturation between the observation group and the control group.The induction time in the observation group was shorter than the control group, and the leaving hospital time was longer than the control group(P<0.05).There was no significant difference in the incidence of hypotension and tachycardia between the two groups of patients.The incidence of adverse reactions in observation group was lower than that in control group, the difference was statistically significant(P<0.05).Conclusion In gastrointestinal endoscopy, midazolam combined with fentanyl and propofol is feasible and safe, because of steady hemodynamics, faster induction without prolonged recovery, reduce the incidence of adverse reactions.

Inflammatory bowel disease,a type of intestinal chronic inflammatory disease caused by multi-factors,which include ulcerative colitis,Crohn's disease and inflammatory bowel disease unclassified.The morbidity of inflammatory bowel disease has been increasing by years with a younger age trend.Nowadays the pediatric inflammatory bowel disease is prevalent.Pediatric inflammatory bowel disease is different from adult at many aspects such as clinical manifestation,disease type,treatment,complications etc.It is because children are in a special condition with fast growth and development.This article will elaborate the current status of treatment and progresses of inflammatory bowel disease especially pediatric inflammatory bowel disease.

Tandem-pore-domain potassium channels are a diverse and highly regulated superfamily of channels that are thought to provide baseline regulation of membrane excitability. Of these, TREK are highly expressed in human CNS. TREK can be regulated by both physical and chemical factors. Lately, study on knockout animals suggested that TREK-1 might participate in the process of general anesthesia of some anesthetics.

The relationship of Bdellovibrio and microbiological pollution was observed in laboratory.The results showed that the number of bd ellovibrio increased some time later than the introduction of polluted microbes and remained on high level after the pollution.These characteristics may have potential on indicating pollution.