Objective To implore FHIT expression in the tissue of cervical carcinoma and its clinical significance. Methods To determine the FHIT expression in 42 cases of cervical carcinoma by S2P immunohistochemical staining and to make a comparison with the normal one. Results The FHIT expression in normal tissue showed to be normal or even positive. No descending or short one occurred. The expression in cervical carcinoma was significantly low or short, abnormal one reached 57.14 %. The descending and short expression had something to do with histological type and grade (P 0.05). Conclusions The ascending or descending of FHIT expression plays an important role, which might influence the prognosis of cervical carcinoma.

Juvenile polyps are the most common colorectal polyps in children,usually present with painless,intermittent rectal bleeding.Colonoscopy is used to diagnose and juvenile polyps should be removed once found.The etiology and pathogenesis of juvenile polyps is still unclear.Histologically,the typical juvenile polyp is hamartoma with a prominent lamina propria,infiltration with inflammatory cells and cystic glands.This article reviewed the recent progress in the study of the clinical manifestation,histological characteristics,biological characteristics,diagnosis,treatment,pathogeny and molecular mechanisms of colorectal juvenile polyps in children.

The volatile oils from Panax Japonicus C. A. Meyer var major (Burk) Wu et Feng grown in Teng-chong County were analyzed by GC/MS/DS. 27 kinds of components were identified and their relative contents were determined. Among them 10 molecules of sesquiterpene and 1 of sesquiterpenol appeared.

The Volatile Oils from panax Quinquefolius grown in Li-jiang county, Yunnan, China were analysed by GC/MS/DS and standard mass-spectrogram atlas. 26 Kinds of compounds were identified and their relative contents were determined.The Volatile oils from Li-jiang panax Quinquefolius are proved to be significantly different in composition and content from those panax quinquefoliuses imported form abroad or grown in other regions in China.

The highly down-loaded 175 papers from 7 journals of ophthalmology covered in Scopus database in 2011 were analyzed,showing that the most concerned subjects were rintinopathy,macular edema,glaucoma, neovasculariza-tion,Ranibizumab, retinal blood vessel obstruction, OCT,cornea, artificial lens, diabetic retinopathy, nanometer medicine and technology,the research has extended to retro-ocular segment from anterior-ocular segment,the papers of multiple authors accounted for 92%, the reviews accounted for 51.42%and were highly down-loaded.

The source indexes for the coverage of Chinese biomedical journals in MEDLINE were analyzed and compared with the mean values of those for the journals in each subject,which showed that the number of MEDLINE-covered papers published in Chinese medical journals was small ( about 260 papers each year) , the number of au-thors in each paper was 5 and the number of references in each paper was 17 with a half-life of 6. 175 years. The MEDLINE-covered Chinese medical journals did not emphasize on the publication of papers from overseas. However, it seemed that they could attract more found-supported papers.

Besides being able to specially target tumor tissues, anticancer peptides have other advantages such as easy synthesis, low immunogenicity, high potency, low toxicity, and easy access. These peptides exert their anti-tumor effects through mechanisms such as modulating immune system, killing tumor cells directly, and/or inhibiting tumor metastasis.

Objective To study the relationship between B-type natriuretic peptide(BNP) and type 2 diabetes mellitus(DM) patients with congestive heart failure(CHF).Methods 78 patients with DM were divided into pure DM group(n=37) and DM+CHF group(n=41) ,the level of plasma BNP in patients with DM(n=78) and normal control group(n=20) was.measured.Results The level of plasma BNP in grade Ⅱ ,Ⅲ～Ⅳgroup of cardiac function were significantly higher than that in pure DM group and control group(P<0.05),grade Ⅲ～Ⅳ group were significantly higher than that in grade II group(P<0.05),LVEF in Ⅱ,Ⅲ～Ⅳgroup of cardiac function were significantly lower than that in pure DM group and control group(P<0.05),grade Ⅲ～Ⅳ group were significantly lower than that in grade Ⅱ group(P<0.05) ;The level of plasma BNP was positively related to LVEF(r= -0.713,P<0.05).Conclusion BNP was an objective indicator to evaluate the severity of DM with heart failure.

Objective To study the effects of trimetazidine on cardiac function in type 2 diabetes mellitus patients with heart failure. Methods Ninty type 2 diabetes mellitus patients with heart failure were randomly divided into two groups (45 patients in control group,45 patients in treatment group). All patients in both two groups received routine therapy in order to have blood glucose under control,the treatment group was treated with trimetazidine 20mg po Tid ,treatment for 6 months. Before and after treatment ,two groups were detected left ventricular end-diastolic diameter (LVEDD), left ventricular end systolic diameter (LVESD) and left ventricular ejection fraction (LVEF), and the clinical efficacy were evaluated. Results Ater treatment, the rate of total efficiency was 68. 9% in control group, and it was 86. 7% in treatment group. The clinical efficacy of treatment group was significantly better than control group(P＜0.05) ;Ater treatment,LVEDD,LVESD were significantly reduced than those before treatment(P ＜0.05) ,LVEF was significantly higher than that before treatment (P ＜0.05);After treatment,LVEDD, LVESD in treatment group was significantly reduced than those in control group, LVEF was significantly higher than control group (P ＜ 0.05).Conclusion Trimetazidine can significantly improve the cardiac function in type 2 diabetes mellitus patients with heart failure.

BACKGROUND: Myasthenia gravis is a spectrum of disease that there are varied options of treatment. A consensus guideline is conceived by the Neuromuscular Council of the Philippine Neurological Association to summarize all the possible options of treatment in generalized autoimmune myasthenia gravis.
METHODS: Articles were retrieved from 1966 to 2012 from the internet, appraised, summarized, and consolidated to come up with recommendations in this treatment guideline. The American Academy of Neurology classification of evidence (Class I,II,III,IV) and levels of recommendations (Level A, B, C. U) were used.
RESULTS: New insights were found on the pathophysiology of autoimmune myasthenia gravis; reviews and outcome of treatment groups as well as the newest immunosuppressant which is rituximab as added to the armamentarium of medical immunosuppression. There are only a few small population randomized controlled trials on some immunosuppressant drugs like cyclosporine, tacrolimus and mycophenolate. Most studies are retrospective or open labelled studies. Thus, most recommendation grade is at Level C.
CONCLUSION: This guideline summarizes the following: Pyridostigmine is the initial treatment for the mild stage or beginning of myasthenia symptoms. For rapid progressive illness, the option of thymectomy is introduced followed by prednisone followed by azathioprine . For poor responders, the following are additional options: cyclosphosphamide, cyclosporine, mycophenolate, tacrolimus, methotrexate and rituximab. Management of MG crisis is mechanical ventilation, plasma exchangeor IVIg with prednisone and/or azathioprine. IV cyclophosphamide may be given for resistant severe crisis of MG patients.

Human ; Azathioprine ; Tacrolimus ; Thymectomy ; Prednisone ; Cyclosporine ; Pyridostigmine Bromide ; Rituximab ; Methotrexate ; Immunoglobulins, Intravenous ; Respiration, Artificial ; Immunosuppressive Agents ; Myasthenia Gravis ; Cyclophosphamide ; Neurology