1.Cerebral Protection by Zhuyu Annao Pill against Cerebral Hemorrhage in Model Rats
China Pharmacy 2007;0(27):-
OBJECTIVE:To observe the protective effect of Zhuyu annao pill on model rats against cerebral hemorrhage. METHODS:The experimental rats were randomized to 6 groups:blank group,model group,Angong liuhuang pill group,Zhuyu annao pill high,medium and low dosage groups. Cephalophyma model of rats were duplicated with rats' autoblood clot; the neurologic impairment change was recorded by integration method; the water content of the brain tissue was measured by dry-wet specific density method; meanwhile,the changes in hemorheology,blood coagulation (4 parameters),the blood coagulation time and the histology of the morphology of brain tissue were observed. RESULTS:In rats treated with Zhuyu annao pill (high,medium or low dosage) as compared with model group,no significant change was noted in the water content and neurological impairment; however,the pro-time (PT) was significantly prolonged(P
2.Recent researches on effects of absorbable internal fixators on epiphyseal plates
Chinese Journal of Orthopaedic Trauma 2004;0(07):-
Nowadays,more and more basic and clinical researches on absorbable internal fixators are car- fled out in China.This paper reviews the recent researches on biodegradation,absorption,and mechanical prop- erties of absorbable internal fixators,their effects on bone mineral density and structure and injury of epiphyseal plate,and their clinical applications.Some problems that have not been solved and future research key points are highlighted and discussed.
3.Advances in science of nutrition
Medical Journal of Chinese People's Liberation Army 1981;0(04):-
Objective To analyze the development status worldwide of nutriology,so as to provide an orientation of its development in the future.Methods The professional articles published were retrieved by information research methods to predict the focal problem,and to provide the demand and presumption of nutriology development.Results In the past 5 years,some innovative concepts and technics were widely used in nutrition studies,such as nutritional genomics,nutritional proteomics and systematic biology,etc.These technologies made it possible to study the influences of nutrients on gene and protein expression,and reversely,the influences of gene changes in nutrient related disturbances in metabolism.Advances in clinical nutritional therapy provides patients with a variety of clinical treatment and the possibility of earty rehabilitation.At present,there are some problems in the fields of nutritional therapy in our country,such as a lack of resource of professional staff,imperfect education system,deficiency in understanding the importance of nutriology,and the lag of standardization and normalization of nutrition information.Conclusions The progress of nutriology in coming five years should lay stress on the parallel development of individual and nationwide health level.A series of studies in molecular biology and systematic biology will upgrade the national physical quality and the basic health condition of population nationwide.
4.Treatment strategies of unresectable metastatic colorectal cancer
Journal of International Oncology 2012;39(10):775-778
Chemotherapy with or without molecule-targeting agents is the primary choice for patients with unresectable metastatic coloreetal cancer. New treatment strategies like intermittent therapy and maintenance therapy may not inferior to treatment until progression or unacceptable toxicity in maintaining the benefit for patients who responded or had stable disease after the first-line therapy,and also can reduce the drug related side effeets and improve the quality of life.
5.Analysis and prevention of the failure reason of internal fixation in peritrochanteric fractures
Chinese Journal of Postgraduates of Medicine 2013;36(32):38-40
Objective To summarize and analyze the failure reason of internal fixation operation in peritrochanteric fractures and propose appropriate prevention measures.Methods The clinical data of 229 patients with peritrochanteric fractures were retrospectively analyzed,the failure reason of internal fixation was analyzed by the univariate and multivariate Logistic regression analysis.Results The univariate analysis showed that the patients' age,gender composition,types of internal fixation had no significantly correlated with the failure of internal fixation (P > 0.05) ; the Garden reset index,bone quality,fracture type and load time had significantly correlated with the failure of internal fixation (P < 0.05).The multivariate Logistic analysis showed that load time was the independent risk factors for fixation failure (OR =13.515).Conclusion The weight-bearing time points should be selected according to the bone quality,fracture type,and degree of intraoperative reset,thereby reducing the risk of surgery failure.
6.Proliferation inhibition effect of docetaxel combined with cisplatin during the course of chemotherapy for osteosarcoma
Orthopedic Journal of China 2006;0(11):-
[Objective]To study the proliferation inhibition effect of decetaxel combined with cisplatin on osteosarcoma cells,and the effect of the drugs during the course of chemotherapy for osteosarcoma.[Method]The effect of docetaxel and cisplatin alone or combined with osteosarcoma cell line HOS-8603 was examined by cell count,morphologic observation,flow cytometry(FCM).The animal model of human osteosarcoma was established in nude mice.They were given docetaxel or cisplatin alone and combined,and a blank control group was set up.Observations on the growth and pathologic markers of osteosarcoma were carried out and pathological examinations were made.[Result]Docetaxel and cisplatin either alone or combined inhibited significantlythe proliferation of osteosarcoma cells and induced obviously apoptosis,and the effect of the drags combined was more effective than that of the drugs alone,Growth inhibition ratio ≥59.34%(P
7.Determination of Serum resistin levels in obstructive sleep apnea hypopnea syndrome patients and the clinical significance evaluation
Chinese Journal of Practical Internal Medicine 2006;0(S1):-
Objective To investigate the change of serum resistin levels in patients with obstructive sleep apnea hypopnea syndrome(OSAHS).MethodsPolysomnography(PSG)was performed in 58 patients with OSAHS and in 26 controls without differences in age and BMI.Serum resistin levels were measured by ELISA.Results(1)Serum resistin levels were significantly higher in patients with OSAHS than those in control group.(2)FPG levels were significantly higher in patients with OSAHS than those in control group.(3)TG levels were significantly higher in patients with OSAHS than those in control group.(4)Serum resistin levels were correlated positively with FPG in obesity patients with OSAHS、nonobesity patients with OSAHS and nonbesity controls group.(5)Serum resistin levels were correlated positively with TG in obesity patients with OSAHS、nonobesity patients with OSAHS and nonbesity controls group.(6)Serum resistin levels were correlated positively with BMI in OSAHS.(7)Serum resistin levels were correlated negatively with LSaO2 in OSAHS.(8)Serum resistin levels were correlated positively with AHI in OSAHS.ConclusionDetermination of serum resistin levels may be the predictors of the severity of OSAHS and it also contributes a lot taking measures to prevent and control the OSAHS complication occurrence and reduce the mortality.
8.Research progress on the regulatory mechanism of gastric cancer stem cell
Journal of International Oncology 2013;(1):57-61
Gastric cancer stem cells are defined as a subset of gastric cancer cells that possess stem cell properties,including self-renewal and multiplex differentiation potential,and have crucial roles in tumor initiation,progression,invasion,metastasis and recurrence.Epithelial-mesenchymal transition (EMT) can facilitate the invasion and metastasis of cancer cells to distant tissues,and confer the metastatic cancer cells some abilities of stem cells.Several transcription factors of EMT,signaling pathways and microRNAs (miRNAs) are involved in the process of regulating gastric cancer stem cells.
9.The importance of early treatment of pelvic fracture combine with hemorrhagic shock
Chinese Journal of Primary Medicine and Pharmacy 2006;0(06):-
Objective To investigate the importance and method of early treatment of pelvic fracture combine with hemorrhagic shock.Methods Review the experience comes from emergent treatment of 74 cases of pelvic fracture combine with hemorrhagic shock in the department of emergent surgery.To study the characteristics,meaningful therapy and the affects to course of pelvic fracture.Results By effective early anti-shock treatment.Conclusion All 74 patients of pelvic fracture combine with hemorrhagic shock were safety recover from shock phase and get further treatment.
10.Clinical research progress of radiotherapy in pharyngeal and laryngeal squamous cell carcinoma
China Medical Equipment 2015;(10):65-68,69
Radiotherapy and chemotherapy are the main treatment means for locally advanced squamous cell carcinoma of the pharynx and larynx, to guarantee efficacy and avoid the damage of radical surgery, so as to preserve the laryngeal function of swallowing and pronunciation.With the progressing of radiotherapy technology,concept of treatment and radiotherapy mode have been advanced constantly,that have prolonged the survival time and improved the quality of life.This study will review the progress of radiotherapy in the pharynx and larynx squamous cell carcinoma, investigate the improvement of radiotherapy technology and hypofractionated IMRT, and provide reference for reducing the toxicity and after effects of radiotherapy.