23 rabbits were bilaterally vasectomized and investigated for 12 months with 17 normal male rabbits as control. It was found that (1) positive results of leucocyte adhesion inhibition test occured in 43.5% of the vasectomized rabbits and a significant difference of positive rate was found between 10 and 12 monthes after vasectomy, (2) pathomorphological findings in the immune organs of the vasectomized rabbits showed that the lymph tissues proliferated. The pathomorphological findings were found to be in line with the result of leucocyte adhesion inhibition test.

OBJECTIVE: To explore the way of developing and improving clinical pharmacy. METHODS: According to the experience of specialized clinical pharmacist, the matters that must be resolved were found out in order to probe into suitable resolutions. RESULTS & CONCLUSION: Specialized clinical pharmacist is the direction of developing clinical pharmacist. Clinical pharmacist’s round and consultation obtain achievements, which should be continued. A lot of things should be put into practice including pharmacoeconomics,evidence-based pharmacy, pharmaceutical care to promote the development of clinical pharmacy. Clinical pharmacist should overcome various difficulties and promote rational use of drugs and clinical pharmacy to guarantee the safety of drug use.

To investigate the cause,pathogenesis,monifestation and treatment of osteoporosis and bonic arthritis.Bonic arthristis was not the osteoposis.Osteoporosis and bonic arthristis may occured simultaneously.In order to treat the conditions correctly,differentiated diagrosis should be noticed clinically.

With the aging of the population, the incidence of osteoporotic fractures is increasing year by year, which leads to a heavy burden to society and families. Preventing osteoporotic fractures and re-fractures are critical issues and current challenges in our country. At present, most patients with high risk of osteoporotic fractures are identified in hospitals after fractures. Due to lack of proper understanding of osteoporotic fractures and a comprehensive management system, clinicians only focus on to the treatment of the fracture itself, and pay less attention to the prevention of long-term fractures. Epidemiological data show that in patients with high risk of osteoporotic fracture or those having first fractures, the risk of reoccurring fractures within 2 years is significantly increased, and the risk of death also continues to increase. This is defined as imminent fracture risk, and it is one of the pressing areas that we can and should start to take action in clinic. Taking into considecation of national conditions, this article analyzes current gaps in the risk management of osteoporotic fractures and proposes strategies from aspects of high-risk population identification, treatment, and multidisciplinary cooperation.

OBJECTIVE:To deepen clinical pharmacy work and train special clinical pharmacists in the cardiovascular department.METHODS:Clinical pharmacy working mode approved by clinical staff and patients was established for pharmacists by participating in clinical staff's routine work.RESULTS & CONCLUSION:The system of special clinical pharmacists can help improve clinical pharmacists' approval degree and bring their role into full play in drug treatment and pharmaceutical information service.

OBJECTIVE:To analyze the drug use in the inpatients undergoing allogenic stem cell transplantation.METHODS:The drug use in 24 inpatients undergoing allogenic stem cell transplantation from 2004 to 2007 were analyzed retrospectively in respect of drug variety and drug cost etc.RESULTS:The average drug cost for the inpatients undergoing stem cell transplantation was(66 418.56?24 381.73)yuan,comprising 61.69% of the total cost of hospitalization.The top 20 drugs in terms of consumption sum were mainly drugs for immune system,drugs affecting hematological and hematopoietic system and anti-tumor drugs etc.The top 20 drugs in terms of DDDs were mainly immunosuppressants,anti-tumor drugs and adjunctive drugs,with DUI ≤1 for the majority of the drugs.CONCLUSION:The drug use in the inpatients undergoing allogenic stem cell transplantation in our hospital was rational on the whole.

OBJECTIVE:To investigate the internal quality of 31 batches of Compound Glycyrrhiza oral solutions from different manufacturers.METHODS:The contents of Morphine and Guaifenesin in Compound Glycyrrhiza oral solutions were determined by HPLC,and the pH value of the solution was detected as well.RESULTS:Of the total 31 batches of samples,13 was unqualified in Morphine content,1 was unqualified in Guaifenesin content,and 1 was unqualified in pH value.CONCLUSION:The manufacturers should strictly obey the standards recorded in China Pharmacopoeia in respect of quality control to ensure the safety and efficacy of clinical medication.

The technology,of extracting Semen Cassiae from Jueming Jiangzhi Powder was investigated.The perceutages of extra ction and preservation of anthraquinone were used to select the methods of extra ction, concentration and drying of Semen Cassiae. The optimal procedure was set as follows:the large-size powder of Semen Cassiae was extracted with 50% alcohol for three times, then the extracted liquid was concentrated by vacuum evaporati on and finally dried by spraying.

Objective To investigate the insulin resistance and microalbuminuria in the healthy offspring with a family history of essential hypertension,in order to explore the relationship between the genetic factor and early renal injury.Methods 69 healthy offsprings with the family history of essential hypertension were randomly recruited as the observation group,35 healthy offsprings without the family history of essential hypertension were considered as the control group.The consecutive 12-hour urine was collected to detect the urinary albumin,and blood biochemical examination was conducted.Results Plasma levels of triglyceride (TG),total cholesterol (TC),glucose,fasting insulin,and urinary albumin excretion rate were higher in observation group than in the control group [(1.07±0.65) mmol/L vs.(0.79±0.52) mmol/L,(4.83±0.78) mmol/L vs.(4.48±0.63) mmol/L,(5.27±0.73) mmol/L vs.(4.94±0.85) mmol/L,(10.63±3.21) mIU/L vs.(7.72±3.35) mIU/L,(45.6±29.5) μg/min vs.(18.6±11.7) μg/min,t=2.259、2.348、2.093、4.381、5.337,all P＜0.05].Conclusions Insulin resistance and microalbuminuria occur before hypertension in healthy offsprings with the family history of essential hypertension,and the patients are prone to getting early renal damage,which indicates that heredity is a risk factor for chronic kidney disease.